Results 11 to 20 of about 362 (162)

NEURoaid II (MLC901) in cognitively Impaired not demenTEd patientS (NEURITES): A pilot double blind, placebo‐controlled randomized trial [PDF]

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Objective To investigate the efficacy and safety of MLC901 in vascular cognitive impairment no dementia (VCIND) patients. Design This was a multi‐center, double‐blind, randomized, placebo‐controlled pilot study.
Christopher L. H. Chen, Trọng Hung Nguyen, Simeon Marasigan, Chun Fan Lee, Qingshu Lu, Nagaendran Kandiah, Deidre deSilva, Eddie Chong, Narayanaswamy Venketasubramanian   +8 more
doaj   +2 more sources

The Alzheimer's disease THErapy with NEuroaid (ATHENE) study protocol: Assessing the safety and efficacy of Neuroaid II (MLC901) in patients with mild‐to‐moderate Alzheimer's disease stable on cholinesterase inhibitors or memantine—A randomized, double‐blind, placebo‐controlled trial [PDF]

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019
Background Dementia is a large and growing health care burden globally, and its major cause is Alzheimer's disease (AD). MLC901 (Neuroaid II) is a simplified form of MLC601 (Neuroaid), a Traditional Chinese Medicine with neuroprotective and ...
Christopher L.H. Chen, Purabi Reang Sharma, Boon Yeow Tan, Casuarine Low, Narayanaswamy Venketasubramanian   +4 more
doaj   +2 more sources

Translational Medicine in Acute Ischemic Stroke and Traumatic Brain Injury—NeuroAiD Trials, from Traditional Beliefs to Evidence-Based Therapy [PDF]

Biomolecules
Acute ischemic stroke (AIS) and traumatic brain injury (TBI) are two severe neurological events, both being major causes of death and prolonged impairment.
Narayanaswamy Venketasubramanian, Tseng Tsai Yeo, Christopher Li Hsian Chen   +2 more
doaj   +2 more sources

A scoping review of stroke services within the Philippines. [PDF]

BMC Health Serv Res
Background: Stroke is a leading cause of mortality and disability. In higher-income countries, mortality and disability have been reduced with advances in stroke care and early access to rehabilitation services.
Logan A, Faeldon L, Kent B, Ong A, Marsden J.   +4 more
europepmc   +3 more sources

Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024 [version 3; peer review: 2 approved] [PDF]

F1000Research
1) Introduction Cognitive enhancers, or nootropics, are agents that aim to improve cognitive functions such as memory, attention, and executive processing.
Dwi Arwandi Yogi Saputra, Tirta Darmawan Susanto, ARMAN YURISALDI SALEH, Riezky Valentina   +3 more
doaj   +2 more sources

Effect of Combined Treatment with MLC601 (NeuroAiDTM) and Rehabilitation on Post-Stroke Recovery: The CHIMES and CHIMES-E Studies. [PDF]

Cerebrovasc Dis, 2018
Background and Purpose: MLC601 has been shown in preclinical studies to enhance neurorestorative mechanisms after stroke. The aim of this post hoc analysis was to assess whether combining MLC601 and rehabilitation has an effect on improving functional ...
Suwanwela NC, Chen CLH, Lee CF, Young SH, Tay SS, Umapathi T, Lao AY, Gan HH, Baroque Ii AC, Navarro JC, Chang HM, Advincula JM, Muengtaweepongsa S, Chan BPL, Chua CL, Wijekoon N, de Silva HA, Hiyadan JHB, Wong KSL, Poungvarin N, Eow GB, Venketasubramanian N, CHIMES-E Study Investigators.   +22 more
europepmc   +2 more sources

NeuroAiD^TM-II (MLC901) Promoted Neurogenesis by Activating the PI3K/AKT/GSK-3β Signaling Pathway in Rat Spinal Cord Injury Models [PDF]

Biomedicines
Traumatic damage to the spinal cord (SCI) frequently leads to irreversible neurological deficits, which may be related to apoptotic neurodegeneration in nerve tissue. The MLC901 treatment possesses neuroprotective and neuroregenerative activity.
Anam Anjum, Muhammad Dain Yazid, Muhammad Fauzi Daud, Jalilah Idris, Angela Min Hwei Ng, Amaramalar Selvi Naicker, Ohnmar Htwe Rashidah Ismail, Ramesh Kumar Athi Kumar, Yogeswaran Lokanathan   +8 more
doaj   +2 more sources

Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review. [PDF]

Drug Des Devel Ther
Yisong Ren, Gang Chen, Ying Hong, Qianying Wang, Bo Lan, Zhaozhao Huang Department of Critical Care Medicine, Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, Sichuan Province, 611731, People’s Republic of ChinaCorrespondence ...
Ren Y, Chen G, Hong Y, Wang Q, Lan B, Huang Z.   +5 more
europepmc   +3 more sources

Effectiveness of biomedical interventions on the chronic stage of traumatic brain injury: a systematic review of randomized controlled trials. [PDF]

Front Neurol
Traumatic brain injury (TBI), in any form and severity, can pose risks for developing chronic symptoms that can profoundly hinder patients’ work/academic, social, and personal lives. In the past 3 decades, a multitude of pharmacological, stimulation, and
Kawata K, Rettke DJ, Thompson C, Mannix R, Bazarian JJ, Datta D.   +5 more
europepmc   +3 more sources

Current Status and Evaluation of Randomized Clinical Trials of Traditional Chinese Medicine in the Treatment of Cardiovascular Diseases. [PDF]

Evid Based Complement Alternat Med, 2022
Traditional Chinese medicine has long been applied to various diseases in China for a few thousand years. In recent years, its market has gradually developed from Asian countries to Western countries. At present, due to the lack of evidence‐based medicine research, the effect of traditional Chinese medicine on the prevention and treatment of ...
Guo X, Chen X, Chen J, Tan Z, Yang Y, Zhang H.   +5 more
europepmc   +2 more sources