Results 31 to 40 of about 8,113 (115)

Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD

open access: yesParkinson's Disease, 2011
While the etiology of Parkinson's disease remains largely elusive, there is accumulating evidence suggesting that mitochondrial dysfunction occurs prior to the onset of symptoms in Parkinson's disease.
A. R. Esteves   +4 more
doaj   +1 more source

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda   +5 more
wiley   +1 more source

A periodização tática sob a justificativa das neurociências: habituação e reestruturação das tomadas de decisão

open access: yesRevista Brasileira de Futsal e Futebol, 2018
O presente estudo tem como objetivo descrever a metodologia de treinamento do futebol Periodização Tática (PT), criada pelo professor português Vitor Frade (Campos, 2007; Carvalho, 2006; Gomes, 2006), e especificamente argumentar e por consequência ...
Dênis de Lima Greboggy   +1 more
doaj  

Glaucoma and Psychotropics

open access: yesEuropean Psychiatry, 2022
Introduction Glaucoma is a heterogeneous group of conditions which result in optic neuropathy and visual defects, majorly linked with the increase of intra-ocular pressure (IOP).
T. Cavaco, J. Rema, C. Rodrigues
doaj   +1 more source

Cannabinoid and adenosine A2A receptor crosstalk regulates postnatal and adult hippocampal neurogenesis

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Adult neurogenesis is a tightly regulated process affected by both cannabinoid receptors (CB1 and CB2) and adenosine 2A (A2A) receptors, both of which modulate neural progenitor cell activity. While emerging evidence suggests an interaction between these neuromodulatory systems, the extent and mechanism of their interplay in ...
Rui S. Rodrigues   +8 more
wiley   +1 more source

As bases neurobiológicas do transtorno obsessivo-compulsivo e da síndrome de Tourette The neurobiological bases of obsessive-compulsive disorder and Tourette syndrome

open access: yesJornal de Pediatria, 2004
OBJETIVO: Revisar as teorias e evidências das bases neurobiológicas do transtorno obsessivo-compulsivo e da síndrome de Tourette. FONTES DOS DADOS: Revisão dos estudos que investigam a neuroanatomia, neuroimagem, genética e imunologia desses transtornos.
Marcos T. Mercadante   +3 more
doaj   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux   +26 more
wiley   +1 more source

Consumo de sustancias psicoactivas en Latinoamérica desde el abordaje clínico en neurociencia en la última década: una revisión narrativa

open access: yesEleuthera, 2022
Objetivo. El presente artículo busca realizar un análisis crítico desde las neurociencias, sobre el abordaje clínico del consumo de sustancias psicoactivas (SPA) en Latinoamérica. Metodología.
Lina Marcela Medina Viana   +2 more
doaj   +1 more source

HIV Infection and Opioid Treatment Enable the Engraftment of Kaposi Sarcoma‐Like Tumors Into Immunocompetent Mice

open access: yesJournal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT The Kaposi Sarcoma herpesvirus (KSHV) causes Kaposi sarcoma (KS), primary effusion lymphoma, a lymphoproliferative disease (KSHV‐multicentric Castleman's disease), and a cytokine inflammatory syndrome (KICS). These diseases occur more frequently, though not exclusively, among people living with HIV or other types of immune dysregulation. While
Julian Naipauer   +10 more
wiley   +1 more source

Psicologia e neurociência cognitivas: alguns avanços recentes e implicações para a educação

open access: yesInteração em Psicologia, 2003
Starting with the contribution from psychologists like Piaget and Vygotsky to understanding psychological development the authors comment on some important recent advances in infant psychology research and confront its results with previous postures.
Paulo Estevão Andrade   +1 more
doaj   +1 more source

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