Results 1 to 10 of about 4,885 (162)

A Focus on Astrocyte Contribution to Parkinson’s Disease Etiology [PDF]

Biomolecules, 2022
Parkinson’s disease (PD) is an incurable neurodegenerative disease of high prevalence, characterized by the prominent death of dopaminergic neurons in the substantia nigra pars compacta, which produces dopamine deficiency, leading to classic motor ...
Giselle Prunell, Silvia Olivera-Bravo
doaj   +2 more sources

Targeting autotaxin impacts disease advance in the SOD1-G93A mouse model of amyotrophic lateral sclerosis. [PDF]

Brain Pathol, 2022
The major lysophosphatidic acid (LPA)‐synthesizing enzyme, autotaxin (ATX), controls intrinsic excitability of motor neurons (MNs) through the G‐protein‐coupled receptor LPA1. ATX up‐regulation occurs in the spinal cord of the SOD1‐G93A mouse model of amyotrophic lateral sclerosis (ALS) preceding MN degeneration.
Gento-Caro Á, Vilches-Herrando E, Portillo F, González-Forero D, Moreno-López B.   +4 more
europepmc   +2 more sources

Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage Motoneuron Excitability [PDF]

Frontiers in Molecular Neuroscience, 2021
Intrinsic membrane excitability (IME) sets up neuronal responsiveness to synaptic drive. Several neurotransmitters and neuromodulators, acting through G-protein-coupled receptors (GPCRs), fine-tune motoneuron (MN) IME by modulating background K+ channels
Victoria García-Morales, Victoria García-Morales, Ángela Gento-Caro, Ángela Gento-Caro, Federico Portillo, Federico Portillo, Fernando Montero, David González-Forero, David González-Forero, Bernardo Moreno-López, Bernardo Moreno-López   +10 more
doaj   +2 more sources

Exploring the role of Cdk5 on striatal synaptic plasticity in a 3-NP-induced model of early stages of Huntington’s disease [PDF]

Frontiers in Molecular Neuroscience
Impaired mitochondrial function has been associated with the onset of neurodegenerative diseases. Specifically, certain mitochondrial toxins, such as 3-nitropropionic acid (3-NP), initiate cellular changes within the striatum that closely resemble the ...
Elizabeth Hernández-Echeagaray, Jorge A. Miranda-Barrientos, Elizabeth Nieto-Mendoza, Francisco Miguel Torres-Cruz   +3 more
doaj   +2 more sources

Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer's disease: Potential role in synaptic homeostasis and Aβ pathology through microglial and astroglial cells. [PDF]

Brain Pathol
A proteomic analysis revealed synaptogenesis as the most disturbed signaling pathway in the human entorhinal cortex in Alzheimer's disease. HSP90AA1, PTK2B and ANXA2 proteins are highlighted as key factors that could promote synaptic decline via microglia. Unbalanced expression of HSP90AA1 and PTK2B could decrease microglia activation and Aβ‐clearance.
Astillero-Lopez V, Villar-Conde S, Gonzalez-Rodriguez M, Flores-Cuadrado A, Ubeda-Banon I, Saiz-Sanchez D, Martinez-Marcos A.   +6 more
europepmc   +2 more sources

Efecto neuroprotector de los cannabinoides en las enfermedades neurodegenerativas [PDF]

Ars Pharmaceutica, 2015
Objetivos: Se analiza la situación actual de las investigaciones relacionadas con las sustancias cannabinoides, así como su interacción con el organismo, clasificación, efectos terapéuticos y su uso en las enfermedades neurodegenerativas.
Carlos Suero-García, Lucia Martín-Banderas, Mª Ángeles Holgado   +2 more
doaj   +5 more sources

Striatal Neurodegeneration that Mimics Huntington’s Disease Modifies GABA-induced Currents [PDF]

Brain Sciences, 2018
Huntington’s Disease (HD) is a degenerative disease which produces cognitive and motor disturbances. Treatment with GABAergic agonists improves the behavior and activity of mitochondrial complexes in rodents treated with 3-nitropropionic acid to ...
Jorge Flores-Hernández, Jeanette A. Garzón-Vázquez, Gustavo Hernández-Carballo, Elizabeth Nieto-Mendoza, Evelyn A. Ruíz-Luna, Elizabeth Hernández-Echeagaray   +5 more
doaj   +2 more sources

Neurodegeneración en histiocitosis de células de Langerhans: más que una secuela

Anales de Pediatría
Resumen: La histiocitosis de células de Langerhans (HCL) es actualmente considerada una neoplasia inflamatoria rara de origen mieloide que afecta a diferentes órganos y sistemas, de presentación clínica heterogénea.
Vicente Santa-María López, Ignacio Gutiérrez-Carrasco, Antonio Pérez-Martínez, Carmen Rodríguez-Vigil Iturrate, Susana García-Obregón, Mikael Lorite Reggiori, Thais Murciano Carrillo, Lorena Valero-Arrese, Montse Torrent, Itziar Astigarraga   +9 more
doaj   +2 more sources

Papel del péptido mitocondrial humanina como blanco terapéutico en cáncer y neurodegeneración

NOVA, 2019
La humanina es un péptido derivado de la mitocondria con efectos protectores robustos contra una gran variedad de estímulos citotóxicos en diversos tipos celulares.
Antonela Sofía Asad, Camila Florencia Zuccato, Alejandro Javier Nicola Candia, María Florencia Gottardo, Mariela Alejandra Moreno Ayala, María Susana Theas, Adriana Seilicovich, Marianela Candolfi   +7 more
doaj   +2 more sources

Raw data of the effects of Chlorogenic acid in 3-Nitropropionic acid induced toxicity and genotoxicity [PDF]

Data in Brief, 2017
The raw data showed in this article comes from the published research article entitled “Protective effects of Chlorogenic acid in 3-Nitropropionic acid induced toxicity and genotoxicity” Food Chem Toxicol. 2017 May 3. pii: S0278-6915(17)30226-0.
Alarcón-Herrera Norberto, Flores-Maya Saúl, Bellido Belén, M. García-Bores Ana, Mendoza Ernesto, Ávila-Acevedo Guillermo, Hernández-Echeagaray Elizabeth   +6 more
doaj   +2 more sources