Results 1 to 10 of about 207 (96)
A Focus on Astrocyte Contribution to Parkinson’s Disease Etiology [PDF]
Biomolecules, 2022 Parkinson’s disease (PD) is an incurable neurodegenerative disease of high prevalence, characterized by the prominent death of dopaminergic neurons in the substantia nigra pars compacta, which produces dopamine deficiency, leading to classic motor ...
Giselle Prunell, Silvia Olivera-Bravo
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Targeting autotaxin impacts disease advance in the SOD1-G93A mouse model of amyotrophic lateral sclerosis. [PDF]
Brain Pathol, 2022 The major lysophosphatidic acid (LPA)‐synthesizing enzyme, autotaxin (ATX), controls intrinsic excitability of motor neurons (MNs) through the G‐protein‐coupled receptor LPA1. ATX up‐regulation occurs in the spinal cord of the SOD1‐G93A mouse model of amyotrophic lateral sclerosis (ALS) preceding MN degeneration.
Gento-Caro Á +4 more
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Exploring the role of Cdk5 on striatal synaptic plasticity in a 3-NP-induced model of early stages of Huntington’s disease [PDF]
Frontiers in Molecular NeuroscienceImpaired mitochondrial function has been associated with the onset of neurodegenerative diseases. Specifically, certain mitochondrial toxins, such as 3-nitropropionic acid (3-NP), initiate cellular changes within the striatum that closely resemble the ...
Elizabeth Hernández-Echeagaray +3 more
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Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer's disease: Potential role in synaptic homeostasis and Aβ pathology through microglial and astroglial cells. [PDF]
Brain PatholA proteomic analysis revealed synaptogenesis as the most disturbed signaling pathway in the human entorhinal cortex in Alzheimer's disease. HSP90AA1, PTK2B and ANXA2 proteins are highlighted as key factors that could promote synaptic decline via microglia. Unbalanced expression of HSP90AA1 and PTK2B could decrease microglia activation and Aβ‐clearance.
Astillero-Lopez V +6 more
europepmc +2 more sources
Striatal Neurodegeneration that Mimics Huntington’s Disease Modifies GABA-induced Currents [PDF]
Brain Sciences, 2018 Huntington’s Disease (HD) is a degenerative disease which produces cognitive and motor disturbances. Treatment with GABAergic agonists improves the behavior and activity of mitochondrial complexes in rodents treated with 3-nitropropionic acid to ...
Jorge Flores-Hernández +5 more
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Raw data of the effects of Chlorogenic acid in 3-Nitropropionic acid induced toxicity and genotoxicity [PDF]
Data in Brief, 2017 The raw data showed in this article comes from the published research article entitled “Protective effects of Chlorogenic acid in 3-Nitropropionic acid induced toxicity and genotoxicity” Food Chem Toxicol. 2017 May 3. pii: S0278-6915(17)30226-0.
Alarcón-Herrera Norberto +6 more
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Frontiers in Molecular Neuroscience, 2021 Intrinsic membrane excitability (IME) sets up neuronal responsiveness to synaptic drive. Several neurotransmitters and neuromodulators, acting through G-protein-coupled receptors (GPCRs), fine-tune motoneuron (MN) IME by modulating background K+ channels
Victoria García-Morales +10 more
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Neurología (English Edition), 2023 We performed a retrospective analysis of the patients assessed at our memory unit for whom Alzheimer disease (AD) cerebrospinal fluid biomarker results were available.
R. López-Cuevas +10 more
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Advances in Laboratory Medicine, 2022 El sistema nervioso central es fundamental en el control de la homeostasis y mantenimiento de las funciones fisiológicas del organismo. Sin embargo, sus características bioquímicas hacen que sea especialmente vulnerable al daño oxidativo, lo que ...
Sienes Bailo Paula +12 more
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Revista Peruana de Biología, 2013 Durante los procesos neurodegenerativos la función y viabilidad de las neuronas se reduce. En particular, el incremento patológico en la concentración de calcio intracelular, la alteración de la plasticidad sináptica y apoptosis están implicados en la ...
César Zaa +2 more
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