Results 21 to 30 of about 4,612 (183)
Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer's disease: Potential role in synaptic homeostasis and Aβ pathology through microglial and astroglial cells. [PDF]
Brain PatholA proteomic analysis revealed synaptogenesis as the most disturbed signaling pathway in the human entorhinal cortex in Alzheimer's disease. HSP90AA1, PTK2B and ANXA2 proteins are highlighted as key factors that could promote synaptic decline via microglia. Unbalanced expression of HSP90AA1 and PTK2B could decrease microglia activation and Aβ‐clearance.
Astillero-Lopez V +6 more
europepmc +2 more sources
Neurología (English Edition), 2023 We performed a retrospective analysis of the patients assessed at our memory unit for whom Alzheimer disease (AD) cerebrospinal fluid biomarker results were available.
R. López-Cuevas +10 more
doaj +1 more source
Nature Communications, 2019 The adaptor protein p11 and K+ channel TASK1 have overlapping distributions in the CNS. Here, the authors demonstrate that the transcription factor Sp1 regulates p11 levels, which in turn affects intrinsic membrane properties and can contribute to ...
Victoria García-Morales +11 more
doaj +1 more source
Advances in Laboratory Medicine, 2022 El sistema nervioso central es fundamental en el control de la homeostasis y mantenimiento de las funciones fisiológicas del organismo. Sin embargo, sus características bioquímicas hacen que sea especialmente vulnerable al daño oxidativo, lo que ...
Sienes Bailo Paula +12 more
doaj +1 more source
Neuropathology of phenylketonuria (PKU)
Acta Pediátrica de México, 2014 Untreated phenylketonuria (PKU) causes cognitive, neuropsychological and motor skills impairment as well as microcephaly and demyelization. Persistent hyperphenylalaninemia produces toxicity on neurons and glial cells, alters cortical development, growth
Norma Specola
doaj +1 more source
Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact
Arquivos de Neuro-Psiquiatria, 2016 Multiple sclerosis (MS) was always considered as a white matter inflammatory disease. Today, there is an important body of evidence that supports the hypothesis that gray matter involvement and the neurodegenerative mechanism are at least partially ...
Juan Ignacio Rojas +3 more
doaj +1 more source
Mitocondrias en el cerebro y sus alteraciones en la Enfermedad de Alzheimer
Educación Química, 2022 Las mitocondrias son consideradas como una red mitocondrial donde se producen numerosos eventos de fusión y fisión, en las que el transporte y degradación están altamente regulados.
Clorinda Arias Alvarez +1 more
doaj +1 more source
A Novel Genetic Screen Identifies Modifiers of Age-Dependent Amyloid β Toxicity in the Drosophila Brain [PDF]
, 2017 The accumulation of amyloid β peptide (Aβ) in the brain of Alzheimer's disease (AD) patients begins many years before clinical onset. Such process has been proposed to be pathogenic through the toxicity of Aβ soluble oligomers leading to synaptic ...
Belfiori Carrasco, Lautaro Francisco +5 more
core +1 more source
Anestesia pediátrica y alteraciones durante el desarrollo del sistema nervioso central
Revista Electrónica de AnestesiaR, 2015 Existe una preocupación real sobre el efecto nocivo que puede tener la anestesia general sobre el neurodesarrollo pediátrico. Esta preocupación surge a raíz de varios estudios de cohortes, en ellos se evidenció que los niños menores de 4 años que habían ...
Lucas Rovira-Serrano +1 more
doaj +1 more source