Results 21 to 30 of about 4,885 (162)
Neuropathology of phenylketonuria (PKU)
Acta Pediátrica de México, 2014 Untreated phenylketonuria (PKU) causes cognitive, neuropsychological and motor skills impairment as well as microcephaly and demyelization. Persistent hyperphenylalaninemia produces toxicity on neurons and glial cells, alters cortical development, growth
Norma Specola
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Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact
Arquivos de Neuro-Psiquiatria, 2016 Multiple sclerosis (MS) was always considered as a white matter inflammatory disease. Today, there is an important body of evidence that supports the hypothesis that gray matter involvement and the neurodegenerative mechanism are at least partially ...
Juan Ignacio Rojas +3 more
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Anestesia pediátrica y alteraciones durante el desarrollo del sistema nervioso central
Revista Electrónica de AnestesiaR, 2015 Existe una preocupación real sobre el efecto nocivo que puede tener la anestesia general sobre el neurodesarrollo pediátrico. Esta preocupación surge a raíz de varios estudios de cohortes, en ellos se evidenció que los niños menores de 4 años que habían ...
Lucas Rovira-Serrano +1 more
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Mitocondrias en el cerebro y sus alteraciones en la Enfermedad de Alzheimer
Educación Química, 2022 Las mitocondrias son consideradas como una red mitocondrial donde se producen numerosos eventos de fusión y fisión, en las que el transporte y degradación están altamente regulados.
Clorinda Arias Alvarez +1 more
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A Novel Genetic Screen Identifies Modifiers of Age-Dependent Amyloid β Toxicity in the Drosophila Brain [PDF]
, 2017 The accumulation of amyloid β peptide (Aβ) in the brain of Alzheimer's disease (AD) patients begins many years before clinical onset. Such process has been proposed to be pathogenic through the toxicity of Aβ soluble oligomers leading to synaptic ...
Belfiori Carrasco, Lautaro Francisco +5 more
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Neurología (English Edition), 2021 Objective: This study aimed to investigate the role and prognosis of Alzheimer disease biomarkers in patients with mild cognitive impairment (MCI) at a memory clinic in Latin America.
R.F. Allegri +9 more
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The role of astrocytes with genetic mutations linked to amyotrophic lateral sclerosis
Neurology Perspectives, 2023 Despite advances in the understanding of genetic and molecular aspects of Amyotrophic Lateral Sclerosis (ALS), a rapidly progressive and fatal neurodegenerative disease, the exact pathogenic mechanisms are still largely unknown.
D. Brash-Arias +7 more
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Anales de la Academia de Ciencias de Cuba, 2020 Introducción. El núcleo pedunculopontino (NPP) desempeña un papel esencial en el control motor. La literatura sugiere que el NPP participa en el inicio y progresión de la enfermedad de Parkinson, y que su degeneración temprana precede a la muerte de las ...
Lisette Blanco Lezcano +7 more
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The 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model
Neurología (English Edition), 2017 The neurotoxin 6-hydroxydopamine (6-OHDA) is widely used to induce models of Parkinson's disease (PD). We now know that the model induced by 6-OHDA does not include all PD symptoms, although it does reproduce the main cellular processes involved in PD ...
D. Hernandez-Baltazar +2 more
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Neurología, 2017 Resumen: El neurotóxico 6-hidroxidopamina (6-OHDA) ha sido utilizado para generar modelos de la enfermedad de Parkinson (EP). A la fecha se ha establecido que si bien el modelo neurodegenerativo inducido por la 6-OHDA no reproduce la totalidad de ...
D. Hernandez-Baltazar +2 more
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