Results 91 to 100 of about 9,496,868 (341)

Process evaluation of the response of nursing homes to the implementation of the dementia-specific case conference concept WELCOME-IdA: A qualitative study

BMC Nursing, 2020
Background The implementation of clearly structured dementia-specific case conferences could be an important tool to enable nursing staff to properly analyse and manage challenging behaviour in nursing home residents with dementia.
Daniela Holle, Sonja Teupen, Rabea Graf, Rene Müller-Widmer, Sven Reuther, Margareta Halek, Martina Roes   +6 more
doaj   +1 more source

Acetylation discriminates disease-specific tau deposition

Nature Communications, 2023
Pathogenic aggregation of the protein tau is a hallmark of Alzheimer’s disease and several other tauopathies. Tauopathies are characterized by the deposition of specific tau isoforms as disease-related tau filament structures.
Pijush Chakraborty, Gwladys Rivière, Alina Hebestreit, Alain Ibáñez de Opakua, Ina M. Vorberg, Loren B. Andreas, Markus Zweckstetter   +6 more
doaj   +1 more source

Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases

International Journal of Molecular Sciences, 2020
Under normal physiological conditions the brain primarily utilizes glucose for ATP generation. However, in situations where glucose is sparse, e.g., during prolonged fasting, ketone bodies become an important energy source for the brain.
N. Jensen, H. Z. Wodschow, M. Nilsson, J. Rungby   +3 more
semanticscholar   +1 more source

Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones [PDF]

, 2013
Neurodegenerative diseases are characterized by progressive degeneration of selective neurones in the nervous system, but the underlying mechanisms involved in neuroprotection and neurodegeneration remain unclear.
Abisambra, Ambruso, Andersen, Antunes, Aslihan Ugun-Klusek, Beal, Bedford, Beranova-Giorgianni, Bhandary, Chandra, Chatterjee, Choy, Croisier, Demasi, Dennissen, Ding, Dumitru Constantin-Teodosiu, Ebrahimi-Fakhari, Ellen Billett, Erdelmeier, Federico, Ferreiro, Fisher, Fisher, Fisher, Fisher, Freeman, Fribley, Gandhi, Goemaere, Goldberg, Grune, Hussong, Jain, Jamal Elkharaz, James Lowe, Jin, Jourdain, Kalyanaraman, Kamphuis, Karen Lawler, Kastle, Kim, Krapfenbauer, Leavey, Leuner, Lien, Ling, Lowe, Lynn Bedford, Malhotra, Manevich, Manevich, Mayford, Middeldorp, Morawe, Omura, Orre, Paine, Palacino, Pekny, Pickering, Pickering, Pimentel, Power, Power, Pratico, R John Mayer, Rabilloud, Samali, Schapira, Shringarpure, Slater, Sofroniew, Sofroniew, Strey, Tannu, Tsien, Varcin, Wang, Wang, Wang, Wang, Wang, Wang, Xiong, Yata, Zhang, Zoltewicz   +88 more
core   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Anti-aggregant tau mutant promotes neurogenesis

Molecular Neurodegeneration, 2017
Background The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggregation and pronounced neuronal loss ...
Maria Joseph, Marta Anglada-Huguet, Katharina Paesler, Eckhard Mandelkow, Eva-Maria Mandelkow   +4 more
doaj   +1 more source

The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies

Experimental and Molecular Medicine, 2020
TAR DNA-binding protein 43 (TDP-43) is a highly conserved nuclear RNA/DNA-binding protein involved in the regulation of RNA processing. The accumulation of TDP-43 aggregates in the central nervous system is a common feature of many neurodegenerative ...
Myungjin Jo, Shinrye Lee, Yu-Mi Jeon, Seyeon Kim, Younghwi Kwon, Hyung-Jun Kim   +5 more
semanticscholar   +1 more source

The Role of the Inflammasome in Neurodegenerative Diseases

Molecules, 2021
Neurodegenerative diseases are chronic, progressive disorders that occur in the central nervous system (CNS). They are characterized by the loss of neuronal structure and function and are associated with inflammation.
F. Piancone, F. La Rosa, I. Marventano, M. Saresella, M. Clerici   +4 more
semanticscholar   +1 more source

Enhancing patient engagement in cancer research: a focus on patient‐centric approaches to scientific discovery

Molecular Oncology, EarlyView.
Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda, Marina Reguero, Vanesa Abón, Marta Puyol   +3 more
wiley   +1 more source

Mitochondrial complex I inhibition enhances astrocyte responsiveness to pro-inflammatory stimuli

Scientific Reports
Inhibition of the mitochondrial oxidative phosphorylation (OXPHOS) system can lead to metabolic disorders and neurodegenerative diseases. In primary mitochondrial disorders, reactive astrocytes often accompany neuronal degeneration and may contribute to ...
Lena Wischhof, Amal John Mathew, Lorenzo Bonaguro, Marc Beyer, Dan Ehninger, Pierluigi Nicotera, Daniele Bano   +6 more
doaj   +1 more source