Results 101 to 110 of about 2,554,961 (312)

Nuance of inward rectifying potassium (Kir) channel dysfunctions in neurodegenerative diseases

, 2023
Neurodegenerative disorders are highly prevalent and diverse in nature. Their manifestation largely depends on the cell types involved, with aberrant inflammatory episodes progressively inducing a constellation of phenotypes that are classified into ...
Linlin Ma, Benjamin Garland, Ma, L, Garland, B   +3 more
core   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Process evaluation of the response of nursing homes to the implementation of the dementia-specific case conference concept WELCOME-IdA: A qualitative study

BMC Nursing, 2020
Background The implementation of clearly structured dementia-specific case conferences could be an important tool to enable nursing staff to properly analyse and manage challenging behaviour in nursing home residents with dementia.
Daniela Holle, Sonja Teupen, Rabea Graf, Rene Müller-Widmer, Sven Reuther, Margareta Halek, Martina Roes   +6 more
doaj   +1 more source

Transcranial Sonography Characteristics of Cerebellar Neurodegenerative Ataxias

Cerebellar neurodegenerative ataxias are a group of disorders affecting the cerebellum and its pathways with different neurological structures. Transcranial sonography (TCS) has been used for the evaluation of brain parenchymal structures in various ...
Gorica Marić, Milutin Kostić, Nataša Dragašević-Mišković, Olivera Tamaš, Andona Milovanović, Milija Mijajlović, Tamara Švabić, Marta Jeremić   +7 more
core   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Smartphone-based detection of subtle memory decline in prodromal Alzheimer’s disease

npj Digital Medicine
The slow progression of Alzheimer’s disease (AD) poses a challenge for the quantification of early disease-driven cognitive decline. Here, we show that frequently administered remote and unsupervised digital cognitive assessments can detect differences ...
Sarah E. Polk, Lindsay R. Clark, Kristin Basche, Luca Kleineidam, Wenzel Glanz, Michaela Butryn, Robert Perneczky, Katharina Buerger, Klaus Fliessbach, Christoph Laske, Annika Spottke, Anja Schneider, Jens Wiltfang, Stefan Teipel, Claudia Bartels, Ayda Rostamzadeh, Daniel Janowitz, Boris-Stephan Rauchmann, Ingo Kilimann, Sebastian Sodenkamp, Marie Coenjaerts, Frederic Brosseron, Michael Wagner, Ingo Frommann, Melina Stark, Matthias Schmid, Björn H. Schott, Sterling C. Johnson, Frank Jessen, Emrah Düzel, David Berron   +30 more
doaj   +1 more source

De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus

Frontiers in Cellular Neuroscience, 2014
Aging is accompanied by gradually increasing impairment of cognitive abilities and constitutes the main risk factor of neurodegenerative conditions like Alzheimer’s disease. The underlying mechanisms are however not well understood.
Roman M Stilling, Roman M Stilling, Eva eBenito, Michael eGertig, Vincenzo eCapece, Jonas eBarth, Susanne eBurkhardt, Stefan eBonn, Andre eFischer, Andre eFischer   +9 more
doaj   +1 more source

Biometals in neurodegenerative diseases : mechanisms and therapeutics /

, 2017
Cover; Title page; Copyright page; Contents; Contributors; Preface; Chapter 1 -- Biometals and Alzheimer's Disease; Introduction; The Role of Copper in AD; The Role of Zinc in AD; The Role of Iron in AD; Therapeutic Targeting of Biometals in AD ...

core  

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Memory in Neurodegenerative Disease [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1999
Memory in Neurodegenerative Disease . Edited by alexander i troster. (Pp 413, £60.00 (US $95.00). Published by Cambridge University Press, Cambridge 1998. ISBN 0-521-57192-8. No one can doubt the increasing importance, to affected families and the healthcare system, of Alzheimer’s disease, Parkinson’s disease, and the other degenerative conditions of ...
openaire   +2 more sources