Results 121 to 130 of about 2,554,961 (312)

Ubiquitin in Neurodegenerative Diseases

Brain Pathology, 1993
Immunochemical staining to detect ubiquitin has become an essential technique in evaluating neurodegenerative processes. Age related staining is seen in myelin, in nerve processes in lysosome‐related dense bodies, and in corpora amylacea. There is a constant association between filamentous inclusions and the presence of ubiquitin.
J, Lowe, R J, Mayer, M, Landon
openaire   +2 more sources

Neurobiology Research on Neurodegenerative Disorders

The aim of the following Special Issue was to call for research in the field of neurodegenerative disorders (NDDs) [...
Grażyna Lietzau
core   +1 more source

Protective activity of aromatic amines and imines against oxidative nerve cell death [PDF]

, 2001
Oxidative stress is a widespread phenomenon in the pathology of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
Skutella, T., Behl, Christian, Beyer, Klaus, Moosmann, Bernd, Behl, C., Moosmann, B., Beyer, K., Skutella, Thomas   +7 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Metallothionein and neurodegenerative diseases

Neural Regeneration Research
Neurodegenerative diseases, which mainly include Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Wilson’s disease, and Huntington’s disease, are a group of disorders characterized by loss of neurons in the brain and spinal cord. However, the underlying pathogenetic mechanisms of these disorders remain unclear.
Yufeng Cheng, Yujia Zhao, Ce Chen, Feng Zhang   +3 more
openaire   +2 more sources

Striatal dopamine neurotransmission is altered in age- and region-specific manner in a Parkinson’s disease transgenic mouse

Scientific Reports
Dopamine (DA) plays a critical role in striatal motor control. The drop in DA level within the dorsal striatum is directly associated with the appearance of motor symptoms in Parkinson’s disease (PD).
Jose Medina-Luque, Patrick Piechocinski, Paul Feyen, Carmelo Sgobio, Jochen Herms   +4 more
doaj   +1 more source

Rat models of major neurodegenerative disorders

, 2022
No single animal model can recapitulate all the features of a particular human disease on its own. Historically, rats have been used to study neurobiology and underlying functional networks.
Yu-Taeger, Libo, Nguyen, Huu Phuc, Clemensson, Erik, Novati, Arianna, Singer-Mikosch, Elisabeth   +4 more
core  

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Mitochondrial oxidant stress promotes α-synuclein aggregation and spreading in mice with mutated glucocerebrosidase

npj Parkinson's Disease
In this study, heterozygous expression of a common Parkinson-associated GBA1 variant, the L444P mutation, was found to exacerbate α-synuclein aggregation and spreading in a mouse model of Parkinson-like pathology targeting neurons of the medullary vagal ...
Pietro La Vitola, Eva M. Szegö, Rita Pinto-Costa, Angela Rollar, Eugenia Harbachova, Anthony HV Schapira, Ayse Ulusoy, Donato A. Di Monte   +7 more
doaj   +1 more source

Subjective memory impairment: No suitable criteria for case‐finding of dementia in primary care

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015
Introduction Subjective memory impairment (SMI) might be used for the case‐finding of dementia. Present analyses aim to determine the diagnostic value and the predictive ability of SMI and related worries for the discrimination of patients screened ...
Tilly Eichler, Jochen René Thyrian, Johannes Hertel, Diana Wucherer, Bernhard Michalowsky, Katinka Reiner, Adina Dreier, Ingo Kilimann, Stefan Teipel, Wolfgang Hoffmann   +9 more
doaj   +1 more source