Results 91 to 100 of about 413,699 (314)

Metallothionein and neurodegenerative diseases

Neural Regeneration Research
Neurodegenerative diseases, which mainly include Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Wilson’s disease, and Huntington’s disease, are a group of disorders characterized by loss of neurons in the brain and spinal cord. However, the underlying pathogenetic mechanisms of these disorders remain unclear.
Yufeng Cheng, Yujia Zhao, Ce Chen, Feng Zhang   +3 more
openaire   +2 more sources

Neurodegenerative diseases: challenges [PDF]

Drug Delivery and Translational Research, 2011
Diseases of the aging brain—including Alzheimer’s, Parkinson’s, and Huntington’s—affect the lives of millions and pose a growing threat to public health. These diseases occur as a result of neurodegenerative processes involving the progressive loss of structure or function of neurons, including death of neurons.
openaire   +2 more sources

Leveraging machine learning for digital gait analysis in ataxia using sensor-free motion capture

Communications Medicine
Background Gait disturbances are the clinical hallmark of ataxia. Their severity is assessed within a well-established clinical scale, which only allows coarse scoring and does not reflect the complexity of individual gait deterioration.
Philipp Wegner, Marcus Grobe-Einsler, Lara Reimer, Fabian Kahl, Berkan Koyak, Tim Elter, Alexander Lange, Okka Kimmich, Daniel Soub, Felix Hufschmidt, Sarah Bernsen, Mónica Ferreira, Thomas Klockgether, Jennifer Faber   +13 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Transcranial Sonography Characteristics of Cerebellar Neurodegenerative Ataxias

Cerebellar neurodegenerative ataxias are a group of disorders affecting the cerebellum and its pathways with different neurological structures. Transcranial sonography (TCS) has been used for the evaluation of brain parenchymal structures in various ...
Gorica Marić, Milutin Kostić, Nataša Dragašević-Mišković, Olivera Tamaš, Andona Milovanović, Milija Mijajlović, Tamara Švabić, Marta Jeremić   +7 more
core   +1 more source

Inflammation in CNS neurodegenerative diseases

, 2018
Neurodegenerative diseases, the leading cause of morbidity and disability, are gaining increased attention as they impose a considerable socioeconomic impact, due in part to the ageing community.
Amor, Sandra, Stephenson, Jodie, Nutma, Erik, van der Valk, Paul   +3 more
core   +1 more source

Neurodegenerative diseases

, 2023
Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are major causes of death worldwide and are characterized by a progressive loss of specific neuronal cells.
Mateos, Raquel
core   +1 more source

Smartphone-based detection of subtle memory decline in prodromal Alzheimer’s disease

npj Digital Medicine
The slow progression of Alzheimer’s disease (AD) poses a challenge for the quantification of early disease-driven cognitive decline. Here, we show that frequently administered remote and unsupervised digital cognitive assessments can detect differences ...
Sarah E. Polk, Lindsay R. Clark, Kristin Basche, Luca Kleineidam, Wenzel Glanz, Michaela Butryn, Robert Perneczky, Katharina Buerger, Klaus Fliessbach, Christoph Laske, Annika Spottke, Anja Schneider, Jens Wiltfang, Stefan Teipel, Claudia Bartels, Ayda Rostamzadeh, Daniel Janowitz, Boris-Stephan Rauchmann, Ingo Kilimann, Sebastian Sodenkamp, Marie Coenjaerts, Frederic Brosseron, Michael Wagner, Ingo Frommann, Melina Stark, Matthias Schmid, Björn H. Schott, Sterling C. Johnson, Frank Jessen, Emrah Düzel, David Berron   +30 more
doaj   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Biometals in neurodegenerative diseases : mechanisms and therapeutics /

, 2017
Cover; Title page; Copyright page; Contents; Contributors; Preface; Chapter 1 -- Biometals and Alzheimer's Disease; Introduction; The Role of Copper in AD; The Role of Zinc in AD; The Role of Iron in AD; Therapeutic Targeting of Biometals in AD ...

core