Results 121 to 130 of about 9,496,868 (341)

Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases

International Journal of Molecular Sciences, 2019
Increasing numbers of individuals suffer from neurodegenerative diseases, which are characterized by progressive loss of neurons. Oxidative stress, in particular, the overproduction of Reactive Oxygen Species (ROS), play an important role in the ...
F. Collin
semanticscholar   +1 more source

Spongionella secondary metabolites protect mitochondrial function in cortical neurons against oxidative stress [PDF]

, 2014
Accepted: 8 January 2014 This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Acknowledgments
Alfonso, Amparo, Alonso, Eva, Botana, Luis M, Ebel, Rainer, Houssen, Wael E, Jaspars, Marcel, Leirós, Marta, Rateb, Mostafa E, Rateb, Mostafa Ezzat Mohamed, Sánchez, Jon A   +9 more
core   +4 more sources

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

Aging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Background One of the major hallmarks of Alzheimer's disease (AD)is the aberrant modification and aggregation of the microtubule‐associated protein Tau .
Marta Anglada‐Huguet, Sara Rodrigues, Katja Hochgräfe, Eckhard Mandelkow, Eva‐Maria Mandelkow   +4 more
doaj   +1 more source

Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]

, 2019
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Cruz Hernández, Luis, Espinosa Oliva, Ana María, García Domínguez, Irene, García Revilla, Juan, Herrera Carmona, Antonio José, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Rodríguez Gómez, José Antonio, Ruiz Laza, Rocío, Santiago Pavón, Martiniano, Sarmiento Soto, Manuel, Venero Recio, José Luis   +13 more
core   +2 more sources

UR‐cycleGAN: Denoising full‐body low‐dose PET images using cycle‐consistent Generative Adversarial Networks

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study aims to develop a CycleGAN based denoising model to enhance the quality of low‐dose PET (LDPET) images, making them as close as possible to standard‐dose PET (SDPET) images. Methods Using a Philips Vereos PET/CT system, whole‐body PET images of fluorine‐18 fluorodeoxyglucose (18F‐FDG) were acquired from 37 patients to ...
Yang Liu, ZhiWu Sun, HaoJia Liu
wiley   +1 more source

Genetics of neurodegenerative diseases [PDF]

Neurology Genetics, 2016
This issue contains a number of articles on neurodegenerative diseases, most of them genotypically analyzed with next-generation sequencing. Readers will find articles identifying potential mutations in new genes, articles examining different phenotypes associated with variation in the same gene, and a report showing an unusual phenotype associated ...
openaire   +3 more sources

Glycoproteomics in neurodegenerative diseases [PDF]

Mass Spectrometry Reviews, 2009
AbstractProtein glycosylation regulates protein function and cellular distribution. Additionally, aberrant protein glycosylations have been recognized to play major roles in human disorders, including neurodegenerative diseases. Glycoproteomics, a branch of proteomics that catalogs and quantifies glycoproteins, provides a powerful means to ...
Hwang, Hyejin, Zhang, Jianpeng, Chung, Kathryn A., Leverenz, James B., Zabetian, Cyrus P., Peskind, Elaine R., Jankovic, Joseph, Su, Zhen, Hancock, Aneeka M., Pan, Catherine, Montine, Thomas J., Pan, Sheng, Nutt, John, Albin, Roger L., Gearing, Marla, Beyer, Richard P., Shi, Min, Zhang, Jing   +17 more
openaire   +4 more sources

Peripheral whole blood microRNA expression in relation to vascular function: a population-based study

Journal of Translational Medicine
Background As key regulators of gene expression, microRNAs affect many cardiovascular mechanisms and have been associated with several cardiovascular diseases.
Valentina Talevi, Konstantinos Melas, Gökhan Pehlivan, Mohammed A. Imtiaz, Dennis Manfred Krüger, Tonatiuh Pena Centeno, N. Ahmad Aziz, Andre Fischer, Monique M.B. Breteler   +8 more
doaj   +1 more source

Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases

Cells, 2020
Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease.
Qian Cai, Yu Young Jeong
semanticscholar   +1 more source