Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation. [PDF]
, 2016 Immune abnormalities have been described in some individuals with autism spectrum disorders (ASDs) as well as their family members. However, few studies have directly investigated the role of prenatal cytokine and chemokine profiles on neurodevelopmental
Ashwood, P +10 more
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The Role of Gangliosides in Neurodevelopment [PDF]
Nutrients, 2015 Gangliosides are important components of neuronal cell membranes and it is widely accepted that they play a critical role in neuronal and brain development. They are functionally involved in neurotransmission and are thought to support the formation and stabilization of functional synapses and neural circuits required as the structural basis of memory ...
Palmano, Kate +4 more
openaire +2 more sources
Histamine, Neuroinflammation and Neurodevelopment: A Review [PDF]
Frontiers in Neuroscience, 2021 The biogenic amine, histamine, has been shown to critically modulate inflammatory processes as well as the properties of neurons and synapses in the brain, and is also implicated in the emergence of neurodevelopmental disorders. Indeed, a reduction in the synthesis of this neuromodulator has been associated with the disorders Tourette’s syndrome and ...
Elliott Carthy +2 more
openaire +4 more sources
Contemporary challenges to iodine status and nutrition: the role of foods, dietary recommendations, fortification and supplementation [PDF]
, 2018 Iodine deficiency (ID) in women of childbearing age remains a global public health concern, mainly through its impact on fetal and infant neurodevelopment.
Bouga, M., Combet, E., Lean, M.E.J.
core +1 more source
Neurodevelopment on Route p63 [PDF]
Neuron, 2005 All known members of the p53 gene family, including the two homologs p73 and p63, have multiple biological functions. In neurons, p53 and p73 are known to regulate cell death in the developing and adult nervous system. A report by Jacobs et al. in this issue of Neuron shows that the more ancestral member of this gene family, p63, is an essential ...
Nicotera, Pierluigi, Melino, Gerry
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Sleep disturbances are associated with irritability in ASD children with sensory sensitivities
Journal of Neurodevelopmental Disorders, 2023 Background Parent reports suggest that 44–84% of children with ASD exhibit sleep disturbances that are of clinical concern. Previous studies have reported that, in children with ASD, the severity of sleep disturbances is associated with the severity of ...
Alona Molcho-Haimovich +9 more
doaj +1 more source
Antibiotic use during pregnancy and neurodevelopmental outcomes of offspring in early childhood [PDF]
, 2020 There is limited research on the effects of antibiotic use during pregnancy on neurodevelopmental outcomes of offspring in early childhood. The aim of this study was to investigate associations between antibiotic use during early pregnancy and ...
Gamache, Tressa
core
Competition and boundary formation in heterogeneous media: Application to neuronal differentiation [PDF]
, 2014 We analyze an inhomogeneous system of coupled reaction-diffusion equations representing the dynamics of gene expression during differentiation of nerve cells. The outcome of this developmental phase is the formation of distinct functional areas separated
Perthame, Benoit +2 more
core +6 more sources
Translational Psychiatry, 2023 Stimulants, such as methylphenidate (MPH), are effective in treating attention-deficit/hyperactivity disorder (ADHD), but there is individual variability in response, especially in adults. To improve outcomes, we need to understand the factors associated
Valeria Parlatini +9 more
doaj +1 more source
The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth. [PDF]
, 2010 Previous studies have implicated DTNBP1 as a schizophrenia susceptibility gene and its encoded protein, dysbindin, as a potential regulator of synaptic vesicle physiology.
Chan, LN +9 more
core +2 more sources