Results 41 to 50 of about 6,773 (216)

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Reliably quantifying the severity of social symptoms in children with autism using ASDSpeech

Translational Psychiatry
Several studies have demonstrated that the severity of social communication problems, a core symptom of Autism Spectrum Disorder (ASD), is correlated with specific speech characteristics of ASD individuals.
Marina Eni, Yaniv Zigel, Michal Ilan, Analya Michaelovski, Hava M. Golan, Gal Meiri, Idan Menashe, Ilan Dinstein   +7 more
doaj   +1 more source

‘We need to make “shit” sexy’ a qualitative study exploring treatment adherence in adolescents with inflammatory bowel disease

Health Psychology and Behavioral Medicine
Background: Adolescents with inflammatory bowel disease (IBD) are faced with the complexities of acquiring self-management behaviours at a time when they are also navigating developmental challenges associated with adolescence. To date, limited treatment
Cassandra Screti, Lou Atkinson, Rachel Shaw, Rafeeq Muhammed, Gemma Heath   +4 more
doaj   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Neurodevelopment and climate change

Jornal de Pediatria
This article aims to assess the impact of climate change, a reality already present on the neurodevelopment of both neurotypical and atypical children.A narrative review of the literature was carried out based on articles available in the PubMed database, published in the last five years using the keywords neurodevelopment and climate change, as well ...
Magda Lahorgue Nunes, Antônio José Ledo Alves da Cunha   +1 more
openaire   +3 more sources

The Neurodevelopment of Empathy in Humans [PDF]

Developmental Neuroscience, 2010
Empathy, which implies a shared interpersonal experience, is implicated in many aspects of social cognition, notably prosocial behavior, morality and the regulation of aggression. The purpose of this paper is to critically examine the current knowledge in developmental and affective neuroscience with an emphasis on the perception of pain in others.
openaire   +2 more sources

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Neural compensation in adulthood following very preterm birth demonstrated during a visual paired associates learning task

NeuroImage: Clinical, 2014
Very preterm birth (VPT;
Philip J. Brittain, Sean Froudist Walsh, Kie-Woo Nam, Vincent Giampietro, Vyacheslav Karolis, Robin M. Murray, Sagnik Bhattacharyya, Anastasia Kalpakidou, Chiara Nosarti   +8 more
doaj   +1 more source

Predicting preschool children's emotional eating: The role of parents' emotional eating, feeding practices and child temperament

Maternal and Child Nutrition, 2022
Emotional eating (EE; defined as overeating irrespective of satiety and in response to emotional states) develops within childhood, persists into adulthood, and is linked with obesity.
Rebecca A. Stone, Jacqueline Blissett, Emma Haycraft, Claire Farrow   +3 more
doaj   +1 more source

Neurodevelopment and Recovery From Wasting

Pediatrics, 2022
BACKGROUND AND OBJECTIVES Acute illness with malnutrition is a common indication for hospitalization among children in low- and middle-income countries. We investigated the association between wasting recovery trajectories and neurodevelopmental outcomes in young children 6 months after hospitalization for an acute ...
Harriet M. Babikako, Céline Bourdon, Emmie Mbale, Peace Aber, Annet Birabwa, Josephine Chimoyo, Wieger Voskuijl, Zaubina Kazi, Paraskevi Massara, John Mukisa, Ezekiel Mupere, Margaret Nampijja, Ali Faisal Saleem, Luke S. Uebelhoer, Robert Bandsma, Judd L. Walson, James A. Berkley, Christina Lancioni, Melissa Gladstone, Meta van den Heuvel   +19 more
openaire   +4 more sources