Results 61 to 70 of about 98,574 (255)

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Mdivi-1 improves cognitive dysfunction in immature SD rats induced by hypoxia combined with propofol by inhibiting excessive mitophagy

陆军军医大学学报
Objective To investigate the protective effect of mitochondrial division inhibitor 1 (Mdivi-1), a mitophagy inhibitor, on cognitive dysfunction in immature SD rats induced by hypoxia combined with propofol.
XU Yao, YANG Shun, YANG Fei
doaj   +1 more source

Epigenetic studies of neurodevelopment in twins

, 2022
Epigenetic studies of neurodevelopment in ...
Yuk Jing Loke (13596721), Namitha Mohandas (278371), Yen Ting Wong (7428737), Jeffrey Craig (13065240), Garth Stephenson (13072002)   +4 more
core  

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

A Self-led Self-management Intervention Supporting Teens with IBD (ASSIST-IBD): protocol for a feasibility study of a novel digital treatment adherence intervention

BMJ Open
Introduction Treatment non-adherence is common in young people with inflammatory bowel disease (IBD), yet support is lacking. A self-led self-management intervention supporting teens with IBD (ASSIST-IBD) is a new theory-based digital treatment adherence
Rafeeq Muhammed, Rachel Shaw, Gemma Heath, Lou Atkinson, Cassandra Screti   +4 more
doaj   +1 more source

Parenteral Nutrition Compromises Neurodevelopment of Preterm Pigs

, 2014
Background: Despite advances in nutritional support and intensive care, preterm infants are at higher risk of compromised neurodevelopment.
Buddington, Randal K., Karyl K Buddington, Choudhri, Asim F., Helen J Sable, Randal K Buddington, Viktor V Chizhikov, Asim F Choudhri, Buddington, Karyl K., Sable, Helen J., Chizhikov, Viktor V.   +9 more
core   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

A novel variant of DNM1L expanding the clinical phenotypic spectrum: a case report and literature review

BMC Pediatrics
Background Mitochondrial diseases are heterogeneous in terms of clinical manifestations and genetic characteristics. The dynamin 1-like gene (DNM1L) encodes dynamin-related protein 1 (DRP1), a member of the GTPases dynamin superfamily responsible for ...
Zhenkun Zhang, Xiaofan Bie, Zhehui Chen, Jing Liu, Zhenhua Xie, Xian Li, Mengjun Xiao, Qiang Zhang, Yaodong Zhang, Yanling Yang, Dongxiao Li   +10 more
doaj   +1 more source

Multi‐Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue‐ and Trait‐Specific Animal Model Selection

Advanced Science, EarlyView.
We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Jingwen Dou, Yong Liao, Xiong Shen, Xin Huang, Zhenshuang Tang, Yuwei Gou, Huajun Zhou, Jingya Xu, Hong Liu, Yue Wang, Keke Liang, Jia Liu, Xiao Zhang, Chenyao Li, Shangjian Wang, Liangliang Fu, Lilin Yin, Xinyun Li, Shuhong Zhao, Xiaolei Liu, Jingjin Li, Yuhua Fu   +21 more
wiley   +1 more source

Artificial intelligence for tracking social behaviours and supporting an autism spectrum disorder diagnosis: systematic review and meta-analysisResearch in context

EBioMedicine
Summary: Background: Artificial intelligence (AI) holds promise for developing tools that can track social behaviours and support clinical assessments and outcomes in Autism Spectrum Disorders (ASD).
Carter Sun, Alistair McEwan, Kelsie A. Boulton, Eleni Andrea Demetriou, Ayesha K. Sadozai, Amit Lampit, Adam J. Guastella   +6 more
doaj   +1 more source