Results 1 to 10 of about 7,929 (69)

Dyslexia as a Neurodevelopmental Disorder and What Makes It Different from a Chess Disorder

Brain Sciences, 2018
The convenience of referring to dyslexia as a neurodevelopmental disorder has been repeatedly brought into question. In this opinion article, we argue in favor of the current diagnosis of dyslexia based on the criteria of harm and dysfunction. We discuss
Gorka FragaGonzález, Iliana I. Karipidis, Jurgen Tijms   +2 more
doaj   +3 more sources

Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia

Life Science Alliance, 2022
A novel mouse model of induced-usual interstitial pneumonia shows bimodal fibrosis with honeycombing, similar to chronic lung disease seen with idiopathic pulmonary fibrosis.
Yoko Miura, Maggie Lam, Jane E Bourke, Satoshi Kanazawa   +3 more
doaj   +1 more source

Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons

eLife, 2023
Expressions of voltage-gated sodium channels Nav1.1 and Nav1.2, encoded by SCN1A and SCN2A genes, respectively, have been reported to be mutually exclusive in most brain regions.
Tetsushi Yamagata, Ikuo Ogiwara, Tetsuya Tatsukawa, Toshimitsu Suzuki, Yuka Otsuka, Nao Imaeda, Emi Mazaki, Ikuyo Inoue, Natsuko Tokonami, Yurina Hibi, Shigeyoshi Itohara, Kazuhiro Yamakawa   +11 more
doaj   +1 more source

Suppression of epithelial abnormalities by nintedanib in induced-rheumatoid arthritis-associated interstitial lung disease mouse model

ERJ Open Research, 2021
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is relevant for the prognosis in patients with RA. Nintedanib, which inhibits both receptor and non-receptor type tyrosine kinases, is an antifibrotic drug for the treatment of ...
Yoko Miura, Hirotsugu Ohkubo, Akio Niimi, Satoshi Kanazawa   +3 more
doaj   +1 more source

Pathophysiological conditions induced by SARS-CoV-2 infection reduce ACE2 expression in the lung

Frontiers in Immunology, 2022
SARS-CoV-2 infection causes a variety of physiological responses in the lung, and understanding how the expression of SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), and its proteolytic activator, transmembrane serine protease 2 (TMPRSS2 ...
Yoko Miura, Hirotsugu Ohkubo, Akiko Nakano, Jane E. Bourke, Satoshi Kanazawa   +4 more
doaj   +1 more source

CTLA-4-Ig internalizes CD80 in fibroblast-like synoviocytes from chronic inflammatory arthritis mouse model

Scientific Reports, 2022
CD80 interact with CD28 and CTLA-4 on antigen-presenting cells, and function in the co-stimulatory signaling that regulates T cell activity. CTLA-4-Ig is used to treat RA by blocking co-stimulatory signaling. Chronic inflammatory arthritis was induced in
Yoko Miura, Shyuntaro Isogai, Shinji Maeda, Satoshi Kanazawa   +3 more
doaj   +1 more source

Language Outcomes of Children Born Very Preterm in Relation to Early Maternal Depression and Anxiety

Brain Sciences, 2023
Unaddressed maternal psychological distress within the first year postpartum is known to have numerous negative consequences on the child’s developmental outcomes, including language acquisition.
Sisan Cuervo, Nancy Creaghead, Jennifer Vannest, Lisa Hunter, Chiara Ionio, Mekibib Altaye, Nehal A. Parikh   +6 more
doaj   +1 more source

Neurodevelopmental Trajectories and Clinical Profiles in a Sample of Children and Adolescents With Early- and Very-Early-Onset Schizophrenia

Frontiers in Psychiatry, 2021
Schizophrenia before the age of 18 years is usually divided into two categories. Early-onset schizophrenia (EOS) presents between the ages of 13 and 17 years, whereas very-early-onset schizophrenia (VEOS) presents at or before the age of 12 years ...
Maria Pontillo, Roberto Averna, Maria Cristina Tata, Fabrizia Chieppa, Maria Laura Pucciarini, Stefano Vicari, Stefano Vicari   +6 more
doaj   +1 more source

Epilepsy protein Efhc1/myoclonin1 is expressed in cells with motile cilia but not in neurons or mitotic apparatuses in brain

Scientific Reports, 2020
EFHC1 gene encodes the myoclonin1 protein, also known as Rib72-1. Pathogenic variants in EFHC1 have been reported in patients with juvenile myoclonic epilepsy (JME).
Toshimitsu Suzuki, Ikuyo Inoue, Kazuhiro Yamakawa   +2 more
doaj   +1 more source

Fat Content Modulates Rapid Detection of Food: A Visual Search Study Using Fast Food and Japanese Diet

Frontiers in Psychology, 2017
Rapid detection of food is crucial for the survival of organisms. However, previous visual search studies have reported discrepant results regarding the detection speeds for food vs.
Reiko Sawada, Reiko Sawada, Wataru Sato, Motomi Toichi, Motomi Toichi, Tohru Fushiki   +5 more
doaj   +1 more source