Results 91 to 100 of about 128,632 (290)

Possible role of mosaic mutations of neurodevelopmental disorder-related genes in bipolar disorder: Lessons from Kmt2c chimeric heterozygous knockout mice

open access: yesNeuroscience Research
We recently found a loss of function mosaic mutation of KMT2C, a causative gene for autism spectrum disorder and Kleefstra syndrome, in a patient with bipolar disorder and reported that somatic mutations in neurodevelopmental disorder-related genes are ...
Takumi Nakamura   +5 more
doaj   +1 more source

An Injectable Electroactive Hydrogel Engineered for Stable Bioelectronic Interfaces

open access: yesAdvanced Materials Interfaces, EarlyView.
Injectable electroconductive hydrogels enable soft, conformal, and stable bioelectronic interfaces for electroceutical therapies. A catechol‐modified hyaluronic acid/alginate/edge‐functionalized graphene platform combines wet adhesion, shear‐thinning injectability, tissue‐matched mechanics, and electrochemical functionality.
Ying Zhou   +11 more
wiley   +1 more source

Febrile Seizures and Subsequent Autism Spectrum Disorder: A Nationwide Population-Based Cohort Study

open access: yesChildren
Objectives: To access the effects of febrile seizures from coexisting neurodevelopmental conditions that are commonly associated with autism spectrum disorder.
Ya-Hsuan Tsai   +2 more
doaj   +1 more source

AYA Cumulative mental disorder and neurodevelopmental disability diagnoses.

open access: yes, 2019
AYA Cumulative mental disorder and neurodevelopmental disability diagnoses.
Lisa Littman (5638547)
core   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

open access: yesAdvanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou   +22 more
wiley   +1 more source

Dyslexia as a Neurodevelopmental Disorder and What Makes It Different from a Chess Disorder

open access: yesBrain Sciences, 2018
The convenience of referring to dyslexia as a neurodevelopmental disorder has been repeatedly brought into question. In this opinion article, we argue in favor of the current diagnosis of dyslexia based on the criteria of harm and dysfunction. We discuss
Gorka FragaGonzález   +2 more
doaj   +1 more source

Reconnecting whānau: Pathways to recovery for Māori with bipolar disorder

open access: yes, 2015
While Māori are known to experience a higher burden of mental health and addiction problems compared to non-Māori (Baxter, 2008), little exploratory research has been conducted into Māori experiences of bipolar affective disorder.
Harris, Parewahaika Erenora Te Korowhiti   +3 more
core  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

open access: yesAdvanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng   +8 more
wiley   +1 more source

Borderline personality: revisiting its classification as a neurodevelopmental disorder

open access: yesFrontiers in Psychiatry
Although borderline personality disorder is classified as a personality disorder, many studies have developed arguments in favor of a neurodevelopmental origin.
Olivier Laurini   +2 more
doaj   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

open access: yesAdvanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis   +32 more
wiley   +1 more source

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