Results 181 to 190 of about 1,509,615 (258)

Expanded characterization of the valproic acid zebrafish larval model of autism spectrum disorder: Insights into dysregulation in the gut

Animal Models and Experimental Medicine, EarlyView.
Meticulous calculation of zebrafish‐equivalent therapeutic valproic acid (VPA) dosage maximized the translational value of the data. Hyposerotonergic tone underpinned an anxiety‐like outcome as a core symptom of autism spectrum disorder (ASD). Compartment‐specific dopaminergic and serotonergic dysregulation in the brain versus gut provided mechanistic ...
Lesha Pretorius, Johanna Adriana Coetzee, Alexio Pedro dos Santos, Carine Smith   +3 more
wiley   +1 more source

Deciphering the Role of LNX2 as a Potential Contributor to Neurodevelopmental Disorders. [PDF]

Genes (Basel)
Vinci M, Figura MG, Musumeci A, Virgillito M, Finocchiaro V, Treccarichi S, Ragalmuto A, Fallea A, Federico C, Saccone S, Calì F.   +10 more
europepmc   +1 more source

Biallelic PIGB Variants Cause Motor Neuropathy with Conduction Blocks and Peripheral Nerve Hyperexcitability

Annals of Neurology, EarlyView.
Objective Glycosylphosphatidylinositol (GPI)‐anchored proteins play critical roles in nervous system function. Pathogenic variants in genes involved in GPI‐anchor biosynthesis cause early‐onset multisystem disorders known as inherited GPI deficiencies. We describe a novel neuromuscular phenotype associated with PIGB deficiency.
Gorka Fernández‐Eulate, Romain Duval, Marina Konyukh, Alessandro Bertini, Ayse Candayan, Albena Jordanova, Theresa Brunet, Wolfgang Müller‐Felber, Helena F. Pernice, Katrin Hahn, Nadja Ehmke, Juliane Beuschlein, Bertrand Isidor, Benjamin Cogné, Yann Péréon, Annabelle Chaussenot, John Rendu, Aysylu Murtazina, Dmitrii Subbotin, Artem Borovikov, Andrey Marakhonov, Chiara Pisciotta, Paola Saveri, Daniele Cazzato, Lucie Lemeray, Bérengère Koehl, Jean‐Madeleine de Sainte‐Agathe, Stefano Facchini, Ilaria Quartesan, Andrea Cortese, Yesim Parman, Arman Cakar, Davide Pareyson, Slim Azouzi, Tanya Stojkovic   +34 more
wiley   +1 more source

A biomimetic ducted nipple reveals gestational age‐dependent deficits in suction generation in a neonatal pig model

The Anatomical Record, EarlyView.
Abstract All infant mammals must suckle in order to effectively acquire milk from a nipple. Yet, not all infants are able to do so. Preterm infants in particular face significant feeding challenges, often failing to establish successful breastfeeding due to complex neurophysiologic challenges.
Max Sarmet, Emily C. Volpe, Elska B. Kaczmarek, Maressa E. Kennedy, Ani E. Smith, Hannah E. Shideler, Harlow I. Smith, Dylan J. Anderson, Thomas H. Stroud, Christopher J. Mayerl   +9 more
wiley   +1 more source

Whole-Exome Sequencing in Patients with Tooth Agenesis and Neurodevelopmental Disorders: A Descriptive Case Series. [PDF]

Int J Mol Sci
Calì F, Musumeci A, Vinci M, L'Episcopo S, Bartolone M, Gloria A, Ferri R, Treccarichi S, Fallea A.   +8 more
europepmc   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Emotion Regulation Difficulties in Autism‐PTSD Co‐Occurrence

Autism Research, EarlyView.
ABSTRACT Autistic individuals face an increased risk of experiencing traumatic events and of being significantly affected by them, whether these events are life‐threatening or social in nature. Emotion regulation (ER) difficulties are central to both conditions, yet their role in this neuropsychiatric co‐occurrence remains under‐researched.
Eldar Fayena, Shir Shaked‐Ashkenazi, Michal Shoval, Mordi Benhamou, Nathaniel Laor, Danny Horesh, Ofer Golan   +6 more
wiley   +1 more source

Electroconvulsive Therapy for Catatonia in Autistic and Non‐Autistic Patients: An Observational Study on Course, Efficacy, Aggression, and Self‐Injury Outcomes

Autism Research, EarlyView.
ABSTRACT Catatonia occurs disproportionately in autistic individuals and may respond to electroconvulsive therapy (ECT), yet prior reports suggest greater treatment burden in this population. We compared longitudinal ECT utilization, safety, and clinical outcomes between autistic and non‐autistic patients with catatonia.
Joshua Ryan Smith, Maria Bonnee, Sarah Marler, Seri Lim, D. Catherine Fuchs, Rafael Tamargo, Isaac Baldwin, Christopher Maley, Ashley VanHaverbeck, Courtney Hamilton, Timothy Adegoke, Haozheng Xu, Jinyuan Liu, Zachary J. Williams, Jo Ellen Wilson, James Luccarelli   +15 more
wiley   +1 more source

Memory processing in neurodevelopmental disorders: linking behavioral, circuits, and molecular scales. [PDF]

Front Cell Neurosci
Sultana S, Ray S, Samaddar S, Banerjee S.   +3 more
europepmc   +1 more source

Clinical and Genetic Factors Associated With Regression in Children With Autism Spectrum Disorders

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with complex genetic and environmental underpinnings. A clinically significant subset of children with ASD experience developmental regression (regASD), characterized by the acute loss of previously acquired skills. The mechanisms, predictors, and molecular basis of
Anna Maruani, Emma Delclaud, Paul Bruzeau, Richard Delorme, Anne‐Claude Tabet, Valérie Vantalon, Jonathan Levy, Pierre Ellul   +7 more
wiley   +1 more source