Results 71 to 80 of about 113,897 (352)

Laryngeal Neuroendocrine Carcinoma

Indian Journal of Otolaryngology and Head & Neck Surgery
Neuroendocrine tumours of the larynx are extremely rare, though they make up only 1% of tumours in this region with the most common site being the supraglottis. On exhaustive research on PubMed, there are only a few prior cases of neuroendocrine carcinoma of subglottis published in the literature.A 56-year-old male presented to our center with ...
Dibangkar Das, Vikas Sharma, Niharika Mishra, Neelam Sharma, Deepak S. Mulajker, Hari Kumar   +5 more
openaire   +3 more sources

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Neuroendocrine carcinoma of the breast

, 2012
SummaryPrimary breast neuroendocrine carcinoma (BNEC) is rare. High-grade BNEC, such as small cell carcinoma and large cell carcinoma, sometimes exhibits specific histological features, and is easily diagnosed.
Lin, Qi-Xuan, Chan, Yi-You, Huang, Ping-Hung   +2 more
core   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Adjuvant radiotherapy in urothelial neuroendocrine carcinoma

, 2020
Neuroendocrine carcinoma cases, more frequent in the gastro-intestinal and pulmonary tract, have rarely been reported also in other areas, including the genito-urinary system. The majority of genitourinary neuroendocrine carcinomas occur in the bladder,
Rossi, R. E., Altomare, M., Mazzaferro, V., Torchio, M., Monteleone, M., Cattaneo, L., Coppa, J.   +6 more
core   +1 more source

Equivalent Survival between Gastric Large-Cell Neuroendocrine Carcinoma and Gastric Small-Cell Neuroendocrine Carcinoma

, 2023
Background: According to the 2019 World Health Organization (WHO) classification of gastric neuroendocrine neoplasms, gastric neuroendocrine carcinoma (GNEC) can be further divided into gastric large-cell neuroendocrine carcinoma (GLNEC) and gastric ...
Yingtai Chen, Zefeng Li, Hu Ren, Zheng Li, Chunguang Guo, Chongyuan Sun, Dongbing Zhao, He Fei, Xiaojie Zhang, Susheng Shi   +9 more
core   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Sinonasal non-small cell neuroendocrine carcinoma the validity of histological grading: Case report and a review of the literature

Otolaryngology Case Reports, 2019
Introduction: Paucity of reported cases and lack of significant follow-up preclude definitive statements regarding the prognosis of sinonasal non-small cell neuroendocrine carcinoma (NSNEC). The validity of histologic grading as a prognostic indicator in
Shivesh Maharaj, Farzana Mahomed
doaj   +1 more source

Metastatic neuroendocrine carcinoma in the skin [PDF]

Dermatology Online Journal, 2017
Cutaneous metastases secondary to neuroendocrinetumors are rare. Herein we report a case of a 75-yearoldwoman who presented with a rare cutaneousmetastatic disease. She was previously diagnosed withmetastatic neuroendocrine carcinoma of unknownprimary, with metastases to liver, lung, and bone.Biopsy of the skin lesion demonstrated archetypicalpathology
Garcia, Andres, Mays, Steven, Silapunt, Sirunya   +2 more
openaire   +4 more sources