Results 181 to 190 of about 245,709 (254)

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Multi-omic profiles of neuroendocrine neoplasms of the pancreas: an integrated landscape. [PDF]

Mol Cancer
Bevere M, Gkountakos A, Valentinuzzi S, De Fabritiis S, Wong CS, De Robertis R, Mattiolo P, Gentiluomo M, Fassan M, Pea A, Crinò SF, Simbolo M, Mafficini A, Campa D, Cingarlini S, Landoni L, Lawlor RT, Salvia R, D'Onofrio M, Milella M, Adsay V, Brosens LA, Heaphy CM, Hong SM, Singhi AD, Scarpa A, Luchini C.   +26 more
europepmc   +1 more source

Incretin‐Based Therapies: A Testable Hypothesis Linking Incretin Signaling, Mitochondrial Redox, and OXPHOS Efficiency

Obesity, EarlyView.
ABSTRACT Objective Incretin‐based obesity therapies (IBTs), especially GLP‐1 receptor agonists (GLP‐1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns ...
Bryn Falahee, Caroline M. Apovian, Nawfal Istfan   +2 more
wiley   +1 more source

Biomarkers and Emerging Approaches in Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NEN): Current Evidence and Future Directions. [PDF]

Cancers (Basel)
D'Orazi G, Monteonofrio L, Verdina A, Garufi A.   +3 more
europepmc   +1 more source

Network based approach identifies miR‐145‐3p as a central regulatory hub associated to the progression from localized to metastatic medullary thyroid carcinoma

The Journal of Pathology, EarlyView.
Abstract Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor originating from calcitonin producing C‐cells and accounts for 1–5% of thyroid cancers. Total thyroidectomy is curative in localized disease (N0), whereas lymph node metastases (N1) are associated with poorer prognosis.
Anna Citarella, Manuela Petti, Zein Mersini Besharat, Caterina Alfano, Elena Splendiani, Sofia Trocchianesi, Sara Cassandro, Martina Chiacchiarini, Claudia Sabato, Francesca Gianno, Tanja Milena Autilio, Martina Brunetti, Giuseppina Catanzaro, Antonella Verrienti, Rossella Elisei, Raffaele Ciampi, Cristina Romei, Maria Grazia Castagna, Silvia Cantara, Vincenzo Marotta, Luciano Pezzullo, Lorenzo Farina, Cosimo Durante, Agnese Po, Elisabetta Ferretti   +24 more
wiley   +1 more source

NUP153 immunoreactivity in neuroendocrine neoplasms supports the diagnosis of NET versus NEC and is modulated by post-translational modifications. [PDF]

J Neuroendocrinol
Mattern S, Ali A, Hollfoth V, Bag E, Kluthe K, Herpel E, Bergmann F, Muley T, Meister M, Lehmann-Koch J, Goeppert B, Warth A, Breuhahn K, Bonzheim I, Singer S, Singer K.   +15 more
europepmc   +1 more source

A transition zone enriched WIF1+ basal cell subtype is associated with benign prostatic hyperplasia

The Journal of Pathology, EarlyView.
Abstract The cellular composition and disease susceptibilities of the distinct zones of the human prostate remain incompletely understood. Benign prostatic hyperplasia (BPH) is a common condition that causes widespread morbidity and is nearly exclusively localized to the transition zone (TZ).
Rulin Wang, Qizhi Zheng, Mindy K Graham, Ajay Vaghasia, Jianyong Liu, Jordan Gregg, Tracy Jones, Anuj Gupta, Nicole Castagna, Yan Zhang, Kornel Schuebel, Jennifer Meyers, Alyza Skaist, Dixie Hoyle, Jasmine Kung, Jessica Hicks, Alok Mishra, Yuhan Yang, William G Nelson, Angelo M De Marzo, Srinivasan Yegnasubramanian   +20 more
wiley   +1 more source

Neuroendocrine neoplasms of the oral cavity: a narrative review of clinicopathological features and management. [PDF]

Discov Oncol
Marino P, Speranza D, Toscano E, Santarpia M, Ballini A, De Vito D, Fazio N, Berretta M, Silvestris N.   +8 more
europepmc   +1 more source

Spatial transcriptomics reveals club cell features and strong CLDN18 expression along the mucinous pathway to invasive mucinous adenocarcinoma

The Journal of Pathology, EarlyView.
Abstract Invasive mucinous adenocarcinoma (IMA) of the lung is a distinct subtype of lung adenocarcinoma with unique clinicopathologic features; however, its histogenesis remains incompletely understood. Although mucinous metaplasia has been suspected as a precursor lesion, direct molecular evidence supporting this progression is limited. In this study,
Joon Young Park, Do Yeon Kim, Hyun Jung Lee, Jung Hee Lee, Hae Ryoun Park, Dong Hoon Shin   +5 more
wiley   +1 more source

Practical considerations for the use of incretin mimetics in patients with neuroendocrine neoplasms: An expert consensus statement. [PDF]

Cancer
Grewal US, Ear PH, Sonbol MB, Bellizzi AM, Hofland J, Crona J, Dillon JS, Chan JA, Howe JR, Strosberg J, Singh S, Halfdanarson TR.   +11 more
europepmc   +1 more source