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Updates on precision medicine of pancreatic neuroendocrine tumor [PDF]
Zhongguo aizheng zazhi, 2023 Since the concept of precision medicine proposed in 2011, the treatment of solid tumors has entered era of precision medicine led by gene testing. As a rare tumor, the incidence rate of pancreatic neuroendocrine tumor (PanNET) is increasing gradually. In
GAO Heli, XU Jin, CHEN Jie, YU Xianjun
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Frontiers in Oncology, 2022 BackgroundThe four major pathways in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) including chromatin remodeling, DNA damage repair, activation of mTOR signaling, and telomere maintenance were mediated by some critical molecules and ...
Xin Lou +51 more
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Tumor size and perineural invasion predict outcome of gastric high-grade neuroendocrine neoplasms
Endocrine Connections, 2021 A new subcategory, grade 3 neuroendocrine tumors, is incorporated into the grading system of pancreatic neuroendocrine neoplasms in the 2017 WHO c lassification in order to differentiate grade 3 neuroendocrine tumors from neuroendocri ne carcinomas.
Qi Zhang +14 more
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Frontiers in Neuroendocrinology, 2001 Tumor markers used in the diagnosis and follow-up of patients with neuroendocrine tumors are in most instances not specific for a given tumor and circulate under normal conditions in the serum, making their use as an early diagnostic tool difficult (low sensitivity).
Lamberts, S.W.J. +2 more
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Discussing motherhood when the oncological prognosis is dire: ethical considerations for physicians
ESMO Open, 2020 Physicians are increasingly open to discussing and supporting pregnancy after cancer treatment. However, counselling patients who are seeking pregnancy despite advanced oncological disease and/or uncertain prognosis is still challenging. Two paradigmatic
Francesca Spada +3 more
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MEN1 promotes ferroptosis by inhibiting mTOR-SCD1 axis in pancreatic neuroendocrine tumors
Acta Biochimica et Biophysica Sinica, 2022 Pancreatic neuroendocrine tumor (pNET) is the second most common malignant tumors of the pancreas. Multiple endocrine neoplasia 1 ( MEN1) is the most frequently mutated gene in pNETs and MEN1-encoded protein, menin, is a scaffold ...
Ye Zeng +16 more
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Clinical study of robot and laparoscopic minimally invasive surgery for well-differentiated pancreatic neuroendocrine tumors [PDF]
Zhongguo aizheng zazhi, 2022 Background and purpose: Pancreatic neuroendocrine tumor (pNET) is a rare tumor. At present, there is still a lack of large-scale clinical research data to summarize the clinical effect of minimally invasive technology in the treatment of pNET. This study
LIU Wensheng, JI Shunrong, ZHUO Qifeng, GAO Heli, SHI Yihua, XU Wenyan, LIU Mengqi, LI Zheng, YU Xianjun, CHEN Jie, XU Xiaowu
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Frontiers in Endocrinology, 2018 Background: Available neuroendocrine biomarkers are considered to have insufficient accuracy to discriminate patients with gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) from healthy controls.
Mark J. C. van Treijen +15 more
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Endocrine Connections, 2019 Introduction: Current monoanalyte biomarkers are ineffective in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). NETest, a novel multianalyte signature, provides molecular information relevant to disease biology.
Anna Malczewska +9 more
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Frontiers in Surgery, 2022 BackgroundPancreatic neuroendocrine tumors (pNETs) and solid pseudopapillary tumors (SPTs) are two of the most common pancreatic neoplasms with different treatment procedures.
Hai-Feng Hu +37 more
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