Results 21 to 30 of about 99,632 (265)

The Interplay of Four Main Pathways Recomposes Immune Landscape in Primary and Metastatic Gastroenteropancreatic Neuroendocrine Tumors

open access: yesFrontiers in Oncology, 2022
BackgroundThe four major pathways in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) including chromatin remodeling, DNA damage repair, activation of mTOR signaling, and telomere maintenance were mediated by some critical molecules and ...
Xin Lou   +51 more
doaj   +1 more source

Tumor size and perineural invasion predict outcome of gastric high-grade neuroendocrine neoplasms

open access: yesEndocrine Connections, 2021
A new subcategory, grade 3 neuroendocrine tumors, is incorporated into the grading system of pancreatic neuroendocrine neoplasms in the 2017 WHO c lassification in order to differentiate grade 3 neuroendocrine tumors from neuroendocri ne carcinomas.
Qi Zhang   +14 more
doaj   +1 more source

Neuroendocrine Tumor Markers

open access: yesFrontiers in Neuroendocrinology, 2001
Tumor markers used in the diagnosis and follow-up of patients with neuroendocrine tumors are in most instances not specific for a given tumor and circulate under normal conditions in the serum, making their use as an early diagnostic tool difficult (low sensitivity).
Lamberts, S.W.J.   +2 more
openaire   +2 more sources

Discussing motherhood when the oncological prognosis is dire: ethical considerations for physicians

open access: yesESMO Open, 2020
Physicians are increasingly open to discussing and supporting pregnancy after cancer treatment. However, counselling patients who are seeking pregnancy despite advanced oncological disease and/or uncertain prognosis is still challenging. Two paradigmatic
Francesca Spada   +3 more
doaj   +1 more source

MEN1 promotes ferroptosis by inhibiting mTOR-SCD1 axis in pancreatic neuroendocrine tumors

open access: yesActa Biochimica et Biophysica Sinica, 2022
Pancreatic neuroendocrine tumor (pNET) is the second most common malignant tumors of the pancreas. Multiple endocrine neoplasia 1 ( MEN1) is the most frequently mutated gene in pNETs and MEN1-encoded protein, menin, is a scaffold ...
Ye Zeng   +16 more
doaj   +1 more source

Clinical study of robot and laparoscopic minimally invasive surgery for well-differentiated pancreatic neuroendocrine tumors [PDF]

open access: yesZhongguo aizheng zazhi, 2022
Background and purpose: Pancreatic neuroendocrine tumor (pNET) is a rare tumor. At present, there is still a lack of large-scale clinical research data to summarize the clinical effect of minimally invasive technology in the treatment of pNET. This study
LIU Wensheng, JI Shunrong, ZHUO Qifeng, GAO Heli, SHI Yihua, XU Wenyan, LIU Mengqi, LI Zheng, YU Xianjun, CHEN Jie, XU Xiaowu
doaj   +1 more source

Clinical value of sentinel lymph node biopsy in patients with cutaneous and acral melanoma [PDF]

open access: yesZhongguo aizheng zazhi, 2022
Background and purpose: For cutaneous and acral malignant melanoma, sentinel lymph node biopsy (SLNB) is an effective tool to evaluate the situation of regional lymph node metastasis and to determine the pathological stage.
ZOU Zijian, SUN Wei, HU Tu, WANG Chunmeng, YAN Wangjun, LUO Zhiguo, LIU Xin, ZHONG Jingqin, LIN Xinyi, XU Yu, CHEN Yong
doaj   +1 more source

Blood Transcript Profiling for the Detection of Neuroendocrine Tumors: Results of a Large Independent Validation Study

open access: yesFrontiers in Endocrinology, 2018
Background: Available neuroendocrine biomarkers are considered to have insufficient accuracy to discriminate patients with gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) from healthy controls.
Mark J. C. van Treijen   +15 more
doaj   +1 more source

NETest liquid biopsy is diagnostic of small intestine and pancreatic neuroendocrine tumors and correlates with imaging

open access: yesEndocrine Connections, 2019
Introduction: Current monoanalyte biomarkers are ineffective in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). NETest, a novel multianalyte signature, provides molecular information relevant to disease biology.
Anna Malczewska   +9 more
doaj   +1 more source

Multimodality imaging differentiation of pancreatic neuroendocrine tumors and solid pseudopapillary tumors with a nomogram model: A large single-center study

open access: yesFrontiers in Surgery, 2022
BackgroundPancreatic neuroendocrine tumors (pNETs) and solid pseudopapillary tumors (SPTs) are two of the most common pancreatic neoplasms with different treatment procedures.
Hai-Feng Hu   +37 more
doaj   +1 more source

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