Results 41 to 50 of about 99,632 (265)

MEN1 Deficiency‐Driven Activation of the β‐Catenin‐MGMT Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers Temozolomide Resistance

Advanced Science
O6‐methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the guanine O6 position (O6‐MG) and repairs DNA damage. High MGMT expression results in poor response to temozolomide (TMZ).
Junfeng Xu, Xin Lou, Fei Wang, Wuhu Zhang, Xiaowu Xu, Zeng Ye, Qifeng Zhuo, Yan Wang, Desheng Jing, Guixiong Fan, Xuemin Chen, Yue Zhang, Chenjie Zhou, Jie Chen, Yi Qin, Xianjun Yu, Shunrong Ji   +16 more
doaj   +1 more source

Complete androgen insensitivity syndrome as a condition requiring interdisciplinary care – A case report

Annales Academiae Medicae Silesiensis
Complete androgen insensitivity syndrome (CAIS; also known as Morris syndrome) is a rare disorder associated with mutations in the androgen receptor gene located on the X chromosome.
Daria Rost, Julia Gniewek, Małgorzata Jekiełek, Janusz Strzelczyk   +3 more
doaj   +1 more source

miR375-3p Distinguishes Low-Grade Neuroendocrine From Non-neuroendocrine Lung Tumors in FFPE Samples

Frontiers in Molecular Biosciences, 2020
Lung cancer is still one of the leading cause of death worldwide. The clinical variability of lung cancer is high and drives treatment decision. In this context, correct discrimination of pulmonary neuroendocrine tumors is still of critical relevance ...
Simone Detassis, Valerio del Vescovo, Margherita Grasso, Stefania Masella, Chiara Cantaloni, Luca Cima, Alberto Cavazza, Paolo Graziano, Giulio Rossi, Mattia Barbareschi, Leonardo Ricci, Leonardo Ricci, Michela Alessandra Denti   +12 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Metastatic neuroendocrine carcinoma to the mandibular gingiva from the duodenum papilla

Oral Oncology Reports, 2023
Neuroendocrine carcinoma is a high-grade carcinoma with morphological and immunohistochemical features of neuroendocrine differentiation. Poorly differentiated neuroendocrine carcinoma which has two subtypes (small cell or large cell type) is extremely ...
Toshinori Iwai, Satomi Sugiyama, Nobuhide Ohashi, Kenji Mitsudo   +3 more
doaj   +1 more source

Renal neuroendocrine tumors

Indian Journal of Urology, 2009
Neuroendocrine tumors (NETs) are uncommon tumors that exhibit a wide range of neuroendocrine differentiation and biological behavior. Primary NETs of the kidney, including carcinoid tumor, small cell carcinoma (SCC), and large cell neuroendocrine carcinoma (LCNEC) are exceedingly rare.The clinicopathologic features of renal NETs diagnosed at a single ...
Brian R Lane, George Jour, Ming Zhou
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Small-Cell Carcinoma of Nasopharynx: A Case Report of Unusual Localization

Ear, Nose & Throat Journal, 2023
Neuroendocrine tumors are a spectrum of rare and highly heterogeneous neoplasms with distinct functional and biological behavior in relation to location, tumor size, and histological differentiation.
Massimo Mesolella MD, Salvatore Allosso MD, Silvia Varricchio MD, Daniela Russo MD, Sara Pignatiello MD, Sarah Buono MD, Gaetano Motta MD   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Primary retroperitoneal neuroendocrine tumor with nonspecific presentation: A case report

Radiology Case Reports, 2020
Primary retroperitoneal tumors are a rare entity of human neoplasms, with primary retroperitoneal neuroendocrine tumors being even more rare. They are usually metastatic and rarely seen as a primary tumor.
Tareq Hamed Al Taei, MB, BCh, BAO, Sarah Ali Al Mail, MD, Abdulaziz Hajjaj Al Thinayyan, MBBS   +2 more
doaj   +1 more source