Results 51 to 60 of about 3,005,108 (342)
Immunotherapy in the neoadjuvant treatment of gastrointestinal tumors: is the time ripe?
Journal for ImmunoTherapy of CancerImmune checkpoint inhibitors (ICIs) revolutionized the management of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancers.
Davide Ciardiello +10 more
doaj +1 more source
miR375-3p Distinguishes Low-Grade Neuroendocrine From Non-neuroendocrine Lung Tumors in FFPE Samples
Frontiers in Molecular Biosciences, 2020 Lung cancer is still one of the leading cause of death worldwide. The clinical variability of lung cancer is high and drives treatment decision. In this context, correct discrimination of pulmonary neuroendocrine tumors is still of critical relevance ...
Simone Detassis +12 more
doaj +1 more source
Lanreotide in metastatic enteropancreatic neuroendocrine tumors.
New England Journal of Medicine, 2014 BACKGROUND Somatostatin analogues are commonly used to treat symptoms associated with hormone hypersecretion in neuroendocrine tumors; however, data on their antitumor effects are limited.
Martyn Caplin +14 more
semanticscholar +1 more source
Sunitinib malate for the treatment of pancreatic neuroendocrine tumors.
New England Journal of Medicine, 2011 BACKGROUND The multitargeted tyrosine kinase inhibitor sunitinib has shown activity against pancreatic neuroendocrine tumors in preclinical models and phase 1 and 2 trials.
E. Raymond +19 more
semanticscholar +1 more source
Diagnostics, 2021 Grade 3 (G3) neuroendocrine tumors (NETs) are a novel category among digestive neuroendocrine neoplasms, characterized by Ki-67 >20% and a well-differentiated morphology, presenting high intra-tumor heterogeneity.
Alice Laffi +11 more
doaj +1 more source
Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future
International Journal of Molecular Sciences, 2019 In recent decades, the incidence of neuroendocrine tumors (NETs) has steadily increased. Due to the slow-growing nature of these tumors and the lack of early symptoms, most cases are diagnosed at advanced stages, when curative treatment options are no ...
A. Stueven +8 more
semanticscholar +1 more source
Advanced ScienceO6‐methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the guanine O6 position (O6‐MG) and repairs DNA damage. High MGMT expression results in poor response to temozolomide (TMZ).
Junfeng Xu +16 more
doaj +1 more source
Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors
Nature Network Boston, 2019 Most pancreatic neuroendocrine tumors (PNETs) do not produce excess hormones and are therefore considered ‘non-functional’1–3. As clinical behaviors vary widely and distant metastases are eventually lethal2,4, biological classifications might guide ...
P. Cejas +26 more
semanticscholar +1 more source
Archives of Pathology & Laboratory Medicine, 2020 CONTEXT.— The 5th edition of the World Health Organization classification of digestive system tumors discusses several advancements and developments in understanding the etiology, pathogenesis, and diagnosis of several digestive tract tumors. OBJECTIVE.
N. Assarzadegan, E. Montgomery
semanticscholar +1 more source
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source