Results 61 to 70 of about 3,005,108 (342)

Updates and management algorithm for neuroendocrine tumors of the uterine cervix

International Journal of Gynecological Cancer, 2019
Neuroendocrine carcinomas of the cervix account for less than 2% of all invasive cervical cancers and are classified as low-grade (carcinoid, atypical carcinoid tumor) or high-grade (known as small- and large-cell) neuroendocrine carcinomas.
G. Salvo, A. González Martín, N. Gonzales, M. Frumovitz   +3 more
semanticscholar   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Neuroendocrine tumors involving the gastroenteropancreatic tract: a clinicopathological evaluation of 773 cases

Clinics, 2011
OBJECTIVE: Description of some of the clinical pathological characteristics of neuroendocrine tumors of the gastroenteropancreatic tract in Brazilian patients.
Bruna Estrozi, Carlos E. Bacchi
doaj   +1 more source

Pancreatic neuroendocrine tumors

Revista Española de Enfermedades Digestivas, 2017
Endocrine or pancreatic neuroendocrine tumors (PNET) were first cited in the 1950s; they may be sporadic or associated with hereditary syndromes, benign or malignant, functioning or non-functioning. Nowadays, NF-PNETs are the most frequent and their prevalence ranges from 50% to 91%. In our current series (including 70 cases, 33% malignant, 52 operated)
Varas-Lorenzo, Modesto J., Cugat-Andorra, Esteban, Capdevila-Castillón, Jaume   +2 more
openaire   +5 more sources

Ghrelin in neuroendocrine tumors [PDF]

Peptides, 2011
Ghrelin is a 28 amino acid peptide, primarily produced by the oxyntic mucosa X/A like neuroendocrine cells in the stomach. It is also found in the small intestine, hypothalamus, pituitary gland, pancreas, heart, adipose tissue, and immune system. In gastrointestinal neuroendocrine tumors (NETs) ghrelin release has been well documented.
Patrizia M. Germano, Patrizia M. Germano, John P. Vu, Hank S. Wang, Hank S. Wang, Joseph R. Pisegna, Joseph R. Pisegna   +6 more
openaire   +3 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Liver transplantation in gastroenteropancreatic neuroendocrine tumors

Frontiers in Oncology, 2023
Neuroendocrine tumors are part of a heterogeneous group of tumors located in organs such as the gastrointestinal tract (GIT), lungs, thymus, thyroid, and adrenal glands. The most prevalent sites are the small intestine, cecal appendix, and pancreas. More
Eduardo de Souza M. Fernandes, Eduardo de Souza M. Fernandes, Eduardo de Souza M. Fernandes, Eduardo de Souza M. Fernandes, Camila V. Garcia Kyt, Camila V. Garcia Kyt, Felipe Pedreira Tavares de Mello, Felipe Pedreira Tavares de Mello, Leandro Savattone Pimentel, Leandro Savattone Pimentel, Ronaldo de Oliveira Andrade, Ronaldo de Oliveira Andrade, Camila Girão, Camila Girão, Camilla César, Camilla César, Munique Siqueira, Munique Siqueira, Maria Eduarda Monachesi, Maria Eduarda Monachesi, Anderson Brito, Claudia Cristina Tavares de Sousa, Wellington Andraus, Orlando Jorge M. Torres, Orlando Jorge M. Torres   +24 more
doaj   +1 more source

The Tumor Microenvironment in Neuroendocrine Tumors: Biology and Therapeutic Implications

Neuroendocrinology, 2019
Neuroendocrine tumors (NETs) include a heterogeneous group of malignancies arising in the diffuse neuroendocrine system and characterized by indolent growth.
M. Cives, E. Pelle’, D. Quaresmini, F. Rizzo, M. Tucci, F. Silvestris   +5 more
semanticscholar   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source