Results 61 to 70 of about 163,967 (239)

IGF-I influences everolimus activity in medullary thyroid carcinoma [PDF]

, 2015
Context: Medullary thyroid carcinoma (MTC) is a rare tumor originating from thyroid parafollicular C cells. It has been previously demonstrated that insulin-like growth factor I (IGF-I) protects MTC from the effects of antiproliferative drugs. Everolimus,
degli Uberti, Ettore C., Di Pasquale, Carmelina, Gagliano, Teresa, GENTILIN, ERICA, MERANTE BOSCHIN, ISABELLA, Pelizzo, Mariarosa, Rossi, Martina, Rossi, Roberta, Tagliati, Federico, Zatelli, Maria Chiara   +9 more
core   +1 more source

MEN1 Deficiency‐Driven Activation of the β‐Catenin‐MGMT Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers Temozolomide Resistance

Advanced Science
O6‐methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the guanine O6 position (O6‐MG) and repairs DNA damage. High MGMT expression results in poor response to temozolomide (TMZ).
Junfeng Xu, Xin Lou, Fei Wang, Wuhu Zhang, Xiaowu Xu, Zeng Ye, Qifeng Zhuo, Yan Wang, Desheng Jing, Guixiong Fan, Xuemin Chen, Yue Zhang, Chenjie Zhou, Jie Chen, Yi Qin, Xianjun Yu, Shunrong Ji   +16 more
doaj   +1 more source

Metastasizing esthesioneuroblastoma in a dog [PDF]

, 2014
A 7-year-old Afghan hound presented with a history of disorientation, loss of vision, and seizures. Magnetic resonance imaging helped identify a mass at the level of the main olfactory bulb that compressed and displaced adjacent tissues in the cribriform
Herden, Christiane, Klingler, Melanie, Schmidt, Martin J., Siudak, Krystyna   +3 more
core   +1 more source

A Retrospective Analysis of the Correlation between Functional Imaging and Clinical Outcomes in Grade 3 Neuroendocrine Tumors (NETs G3)

Diagnostics, 2021
Grade 3 (G3) neuroendocrine tumors (NETs) are a novel category among digestive neuroendocrine neoplasms, characterized by Ki-67 >20% and a well-differentiated morphology, presenting high intra-tumor heterogeneity.
Alice Laffi, Marzia Colandrea, Giuseppe Buonsanti, Samuele Frassoni, Vincenzo Bagnardi, Francesca Spada, Eleonora Pisa, Massimo Barberis, Manila Rubino, Chiara Maria Grana, Francesco Ceci, Nicola Fazio   +11 more
doaj   +1 more source

Tumors in von Hippel–Lindau Syndrome: From Head to Toe—Comprehensive State-of-the-Art Review [PDF]

, 2018
Von Hippel–Lindau syndrome (VHL) is an autosomal-dominant hereditary tumor disease that arises owing to germline mutations in the VHL gene, located on the short arm of chromosome 3.
Bhalla, Sanjeev, Ganeshan, Dhakshinamoorthy, Lubner, Meghan G., Menias, Christine O., Pickhardt, Perry J., Ramalingam, Preetha, Sandrasegaran, Kumaresan   +6 more
core   +1 more source

Primary retroperitoneal neuroendocrine tumor with nonspecific presentation: A case report

Radiology Case Reports, 2020
Primary retroperitoneal tumors are a rare entity of human neoplasms, with primary retroperitoneal neuroendocrine tumors being even more rare. They are usually metastatic and rarely seen as a primary tumor.
Tareq Hamed Al Taei, MB, BCh, BAO, Sarah Ali Al Mail, MD, Abdulaziz Hajjaj Al Thinayyan, MBBS   +2 more
doaj   +1 more source

FGFR2 amplification in colorectal adenocarcinoma [PDF]

, 2017
FGFR2 is recurrently amplified in 5% of gastric cancers and 1%–4% of breast cancers; however, this molecular alteration has never been reported in a primary colorectal cancer specimen.
Carter, Jamal H, Cottrell, Catherine E, Duncavage, Eric J, Heusel, Jonathan W, Lamp, Stephen, McNulty, Samantha N, Vigh-Conrad, Katinka A   +6 more
core   +2 more sources

Pancreatic neuroendocrine tumors

Revista Española de Enfermedades Digestivas, 2017
Endocrine or pancreatic neuroendocrine tumors (PNET) were first cited in the 1950s; they may be sporadic or associated with hereditary syndromes, benign or malignant, functioning or non-functioning. Nowadays, NF-PNETs are the most frequent and their prevalence ranges from 50% to 91%. In our current series (including 70 cases, 33% malignant, 52 operated)
Varas-Lorenzo, Modesto J., Cugat-Andorra, Esteban, Capdevila-Castillón, Jaume   +2 more
openaire   +5 more sources

Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner. [PDF]

, 2019
Heterogeneous prostatic carcinoma-associated fibroblasts (CAF) contribute to tumor progression and resistance to androgen signaling deprivation therapy (ADT).
Agarwal, Priyanka, Angara, Bryan, Bhowmick, Neil A, Billet, Sandrine, Duong, Frank, Haldar, Subhash, Hickok, David, Kato, Manabu, Liu, Zhenqiu, Madhav, Anisha, Mishra, Rajeev, Placencio-Hickok, Veronica R, Rohena-Rivera, Krizia, Smith, Bethany, Tripathi, Manisha   +14 more
core   +1 more source

Neuroendocrine tumors involving the gastroenteropancreatic tract: a clinicopathological evaluation of 773 cases

Clinics, 2011
OBJECTIVE: Description of some of the clinical pathological characteristics of neuroendocrine tumors of the gastroenteropancreatic tract in Brazilian patients.
Bruna Estrozi, Carlos E. Bacchi
doaj   +1 more source