Results 71 to 80 of about 361,579 (250)

Rare genital system tumours, neuroendocrine neoplasms: case series and literature review

Journal of the Pakistan Medical Association
Neuroendocrine neoplasms (NENs) of the female genital tract are rare tumours. They behave more aggressively than other gynaecological cancers.
Tolga Ciftpinar, Yuksel Ulu, Nilufer Cetinkaya Kocadal   +2 more
doaj   +1 more source

The Diagnosis of Neuroendocrine Tumours: An Endocrine Perspective

Endocrinology Research and Practice, 2018
Neuroendocrine tumours are functioning or non-functioning tumours which are derived from neuroendocrine cells scattered throughout the body. The clinical presentation of neuroendocrine tumours depends mainly on the site of the primary tumour and whether ...
Mehtap ÇAKIR, Ashley B. GROSSMAN
doaj   +1 more source

Neuroendocrine tumour markers

, 2011
Neuroendocrine cells occur either singly or in small groups in a variety of tissues and organs. Although morphologically and embryologically diverse, they are characterized by a number of unifying features.
R. Ramachandran, W. Dhillo
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Endoscopic ultrasound-guided fine-needle aspiration vs fine-needle biopsy for the diagnosis of pancreatic neuroendocrine tumors

Endoscopy International Open, 2019
Background and study aims Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) as a method of obtaining preoperative diagnosis of pancreatic neuroendocrine tumors (PanNETs) has been reported in several series.
Leonardo H. Eusebi, Douglas Thorburn, Christos Toumpanakis, Leonardo Frazzoni, Gavin Johnson, Sheida Vessal, Tu Vinh Luong, Martyn Caplin, Stephen P. Pereira   +8 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Use of novel serum markers in clinical follow-up of Sertoli-Leydig cell turnours [PDF]

, 2007
Background: Sertoli-Leyclig cell tumours of the ovary account for only 0.2% of malignant ovarian tumours. Two-thirds of all patients become apparent due to the tumour's hormone production. Methods: A 41-year-old patient (gravida 4, para 4) presented with
Kuemper, Caroline, Diebold, Joachim, Lenhard, Miriam, Ditsch, Nina, Friese, Klaus, Burges, Alexander, Stieber, Petra   +6 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Consensus on biomarkers for neuroendocrine tumour disease [PDF]

, 2015
Management of neuroendocrine neoplasia represents a clinical challenge because of its late presentation, lack of treatment options, and limitations in present imaging modalities and biomarkers to guide management.
Washington, Kay,, Goldenring, James,, De Herder, Wouter,, Metz, David C.,, Strosberg, Jonathan,, Pavel, Marianne,, Heaney, Anthony,, Frilling, Andrea,, Moss, Steven F.,, Meyer, Timothy,, Liu, Eric,, Klimstra, David,, Öberg, Kjell,, Kwekkeboom, Dik,, Wolin, Edward,, Modlin, Irvin M.,   +15 more
core   +2 more sources