Results 71 to 80 of about 202,243 (244)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

MRI of pancreatic neuroendocrine tumours.

, 2001
Neuroendocrine tumours of the pancreas are rare and are frequently difficult to demonstrate. Several imaging modalities have been used to demonstrate these tumours, but recent reports have suggested that MRI may have an important role in their ...
Grossman, AB, Reznek, RH, Sohaib, SA, Monson, JP, Besser, GM, Owen, NJ, Peppercorn, PD   +6 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Small cell carcinoma of the vulva: case report

Clinics and Practice, 2017
Neuroendocrine tumours are rare in the gynaecologic tract, comprising approximately 2% of all gynaecological tumours. They have an aggressive behaviour and are a diagnostic and clinical challenge, due to their rarity and the lack of standardized ...
Ana Correia, Elizabeth Castelo Branco, Paulo Correia, Marcos Guimarães, Luís Sá   +4 more
doaj   +1 more source

Satisfaction and quality of life in patients with symptomatic gastroenteropancreatic neuroendocrine tumours treated with lanreotide Autogel in South Africa

South African Journal of Oncology, 2020
Background: Neuroendocrine tumours are known to impact patients’ quality of life because of the symptoms caused by hypersecretion of serotonin and other peptides, in particular diarrhoea and flushing.
Daleen Geldenhuys, Bernardo L. Rapoport, Samuel Fourie, Waldemar M. Szpak, Sylvia Rodrigues, Anca I. Pirjol, Jill Harris, Michiel Botha, Natalie Jonas, Monique Nel, Celia Bouharati, Alicia McMaster   +11 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Distinct mechanisms of hypoglycaemia in patients with somatostatin-secreting neuroendocrine tumours. [PDF]

, 2019
Introduction Somatostatin-secreting neuroendocrine tumours may present with diabetes, cholelithiasis and steatorrhoea. In addition, hypoglycaemia has been associated with somatostatinomas.
Wiesli, Peter, Wiesli, Peter; https://orcid.org/, Pfammatter, Thomas, Brändle, Michael, Thomas Pfammatter, Schmid, Christoph, Pavlicek, Vojtech, Peter Wiesli, Christoph Schmid, Aurel Perren, Vojtech Pavlicek, Michael Brändle, Perren, Aurel   +12 more
core   +2 more sources

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

A neuroendocrine tumour of the sphenoid sinus and nasopharynx: a case report

B-ENT, 2010
A neuroendocrine tumour of the sphenoid sinus and nasopharynx: a case report. It is rare for neuroendocrine tumours to originate in the sphenoid sinus and the nasopharynx.
V. Vandist, F. Deridder, W. Waelput, P. M. Parizel, P. Van de Heyning, C. Van Laer   +5 more
doaj   +2 more sources

Neuroendocrine Neoplasms of the Esophagus and Esophagogastric Junction in Germany, 2009–2023

Current Oncology
According to the WHO classification of tumors, neuroendocrine neoplasms (NENs) of the esophagus are esophageal “epithelial neoplasms with neuroendocrine differentiation, including well-differentiated neuroendocrine tumours (NETs), poorly differentiated ...
Andreas Stang, Ina Wellmann, Bernd Holleczek, Alice Nennecke, Guido Schumacher, Hiltraud Kajüter   +5 more
doaj   +1 more source