Results 11 to 20 of about 954 (130)
Combined treatment of high-intensity interval training with neural stem cell generation on contusive model of spinal cord injury in rats. [PDF]
Brain Behav, 2023 Neurosphere‐derived NSC transplantation leads to improved motor recovery and axonal growth in the injured spinal cord through induction of neurotrophic factors and Schwann cell proliferation through exercise along with reducing gliosis. Abstract Introduction Spinal cord injury (SCI) leads to inflammation, axonal degeneration, and gliosis.
Keikhaei R +4 more
europepmc +2 more sources
The synergistic ameliorative activity of peroxisome proliferator-activated receptor-alpha and gamma agonists, fenofibrate and pioglitazone, on hippocampal neurodegeneration in a rat model of insulin resistance. [PDF]
Ibrain, 2022 Induction of symptoms of insulin insensitivity with the concomitant administration of streptozotocin (STZ) and a high‐fat diet (HFD) increased the fasting glucose level. This alters the neural activities and morphology of the hippocampus via negative activation of Peroxisome proliferator‐activated receptor (PPARs)‐regulated signaling pathways needed ...
Idowu OK +4 more
europepmc +2 more sources
Post-Covid Alzheimer and Its Remediation via PROTACs Therapy: A Comprehensive Review. [PDF]
Health Sci RepABSTRACT Background and Aims Alzheimer's disease (AD) is a progressive neurodegenerative disorder of aging characterized by memory loss and cognitive decline, associated with amyloid‐β toxicity, tau hyperphosphorylation, and neurofibrillary tangle formation. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) affects the central nervous system
Bhowmick T +5 more
europepmc +2 more sources
Angewandte Chemie, Volume 135, Issue 25, June 19, 2023., 2023 Self‐association of Amyloid‐β (Aβ) into oligomeric, protofibril, annular and fibril assemblies is intimately linked with neuronal toxicity and Alzheimer's disease. Aβ can have a range of impacts on the lipid membrane including a carpeting effect and ion‐channel pore formation.
John H. Viles
wiley +2 more sources
Digestive system deep infiltrating endometriosis: What do we know
Journal of Cellular and Molecular Medicine, Volume 27, Issue 23, Page 3649-3661, December 2023., 2023 Abstract Digestive system infiltrating endometriosis (DSIE) is an uncommon form of endometriosis in the digestive system. DSIE often occurs in the intestines (especially the sigmoid rectum), liver, gallbladder and pancreas. Clinically, DSIE presents with the same symptoms as endometriosis, including cyclic pain, bleeding and infertility, in addition to
Wenze Yin +6 more
wiley +1 more source
Microglial Activation and Connectivity in Alzheimer Disease and Aging
Annals of Neurology, Volume 92, Issue 5, Page 768-781, November 2022., 2022 Objective Alzheimer disease (AD) is characterized by amyloid β (Aβ) plaques and neurofibrillary tau tangles, but increasing evidence suggests that neuroinflammation also plays a key role, driven by the activation of microglia. Aβ and tau pathology appear to spread along pathways of highly connected brain regions, but it remains elusive whether ...
Boris‐Stephan Rauchmann +34 more
wiley +1 more source
Aging Cell, Volume 21, Issue 3, March 2022., 2022 Microglial cathepsin E involves the secretion of TRAIL, resulting in microglia‐mediated neuroinflammation and neuronal Aβ production during AD. Cannula‐delivered Cathepsin E inhibitor improves memory function and reduced neuroinflammation and Aβ production in AD mice.
Zhen Xie +11 more
wiley +1 more source
Brain and Behavior, Volume 12, Issue 1, January 2022., 2022 Perinatal stroke affects ∼1 in 1000 births and concomitant cognitive impairments such as Attention Deficit/Hyperactivity Disorder (ADHD) and executive dysfunction can be disabling. We used diffusion tensor imaging (DTI) to investigate whether stroke‐related differences in frontal white matter (WM) relate to cognitive impairments.
Nicole Larsen +7 more
wiley +1 more source
Computational Intelligence and Neuroscience, Volume 2022, Issue 1, 2022., 2022 In this paper, a comprehensive quantitative and biological neural network optimization model of sports industry structure is thoroughly studied and analyzed using knowledge graphs. To address the problems of poor performance interpretability deficiency of knowledge graph‐based recommendation methods in the face of relational sparse graphs, a ...
Zhaohong Wang +3 more
wiley +1 more source
Stem Cells International, Volume 2022, Issue 1, 2022., 2022 Motor neurons (MNs) derived from human‐induced pluripotent stem cells (hiPSC) hold great potential for the treatment of various motor neurodegenerative diseases as transplantations with a low‐risk of rejection are made possible. There are many hiPSC differentiation protocols that pursue to imitate the multistep process of motor neurogenesis in vivo ...
Catherine Schaefers +5 more
wiley +1 more source