Results 21 to 30 of about 954 (130)

Oxidative Stress and 4‐hydroxy‐2‐nonenal (4‐HNE): Implications in the Pathogenesis and Treatment of Aging‐related Diseases

Journal of Immunology Research, Volume 2022, Issue 1, 2022., 2022
Oxidative stress plays an important role in the development of aging‐related diseases by accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane, resulting in the production of aldehydes, such as malondialdehyde and 4‐hydroxy‐2‐nonenal (4‐HNE) and other toxic substances.
Yanling Li, Tingting Zhao, Jiaxin Li, Mengyao Xia, Yuling Li, Xiaoyu Wang, Chuanguo Liu, Tingting Zheng, Renjie Chen, Dongfang Kan, Yicheng Xie, Jingjie Song, Yu Feng, Tiangui Yu, Peng Sun, Elizabeth Soares Fernandes   +15 more
wiley   +1 more source

Diffusion kurtosis imaging: An efficient tool for evaluating age‐related changes in rat brains

Brain and Behavior, Volume 11, Issue 11, November 2021., 2021
No laterality in the MK and K⊥ values was observed for the EC, CT, or CPu regions of the rat brain. Significant changes in MK and K⊥ values were both observed among different age groups, thus suggesting diffusion kurtosis imaging as an efficient tool for studying brain aging in rats. Abstract Purpose To evaluate and determine age‐related changes in rat
Xue‐Fang Han, Zuo‐Jun Geng, Qing‐Feng Zhu, Zhen‐Hu Song, Huan‐Di Lv   +4 more
wiley   +1 more source

Assessment of dementia in a clinical sample of persons with intellectual disability

Journal of Applied Research in Intellectual Disabilities, Volume 34, Issue 6, Page 1618-1629, November 2021., 2021
Abstract Background Assessment of age‐associated disorders has become increasingly important. Methods In a clinical setting, people with intellectual disability with and without dementia were assessed retrospectively using the Neuropsychological Test Battery (NTB) and the Dementia Questionnaire for People with Learning Disabilities (DLD) at two ...
Peggy Rösner, Justus Berger, Daria Tarasova, Joana Birkner, Heika Kaiser, Albert Diefenbacher, Tanja Sappok   +6 more
wiley   +1 more source

Linking Circadian Rhythms to Gut-Brain Axis Lipid Metabolism Associated With Endoplasmic Reticulum Stress in Alzheimer's Disease. [PDF]

CNS Neurosci Ther
The effect of gut‐brain axis lipid abnormalities metabolism mediated by circadian rhythm disruption on AD were discussed. The membrane lipids abnormalities surrounding sarcoplasmic reticulum Ca2+ ‐ATPase (SERCA) influencing SERCA to release Ca2+ mediate ERS and inflammation, which contribute to neuron damage Aβ accumulation in AD.
Su J, Zhao L, Fu R, Tang Z.
europepmc   +2 more sources

Reconstructing cerebral lymphatic clearance: an emerging target in the Alzheimer's disease therapeutic pipeline

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract Neurotoxic protein accumulation is widely recognized as a key feature of Alzheimer's disease (AD), and increasing evidence indicates that impaired brain clearance associated with dysfunction of the meningeal lymphatic and glymphatic may contribute to this process.
Jiheng Zhang, Jiren Zhang, Jian Ding, Xian Zhang, Yuhua Wang, Wei Wei, Yan Chai, Shu Zhang, Xin Chen   +8 more
wiley   +1 more source

Fluorescence characteristics of dissolved organic matter (DOM) in bottled drinking water of different countries: A potential risk to public health

Water Environment Research, Volume 97, Issue 4, April 2025.
Fluorescence dissolved organic matters (DOM) in bottled drinking water from different countries using fluorescence spectroscopy were characterized. The identified microbial risk because of DOM presence in bottled water can utterly cause severe health problems and economic loss, and raise questions on the efficiency of drinking water treatment ...
Nahin Mostofa Niloy, Mashura Shammi, Shafi M. Tareq   +2 more
wiley   +1 more source

Effect of electroacupuncture on the morphological changes of the spinal dorsal horn and the expression of p38 mitogen-activated protein kinase in the injured spinal cord of rats with neuropathic pain

针刺研究, 2020
Objective To investigate the effect of electroacupuncture stimulation at "Zusanli"(ST36) and "Kunlun"(BL60) on the morphological changes of the spinal dorsal horn and the expression of p38 mitogen-activated protein kinase(p38 MAPK) in the injured spinal ...
ZHOU Ye, WU Qiao-yun, TU Wen-zhan, ZHOU Ke-cheng, LOU Xin-fa, YANG Guan-hu, JIANG Song-he   +6 more
doaj  

Iron‐associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice

Alzheimer's &Dementia, Volume 21, Issue 1, January 2025.
Hypothesis: AD brain lipid peroxidation is driven by increased brain iron and decreased antioxidant defenses. Schema shows proteins that mediate iron metabolism in relation to lipid peroxidation (HNE) and antioxidant defenses in the prefrontal cortex.
Max A. Thorwald, Jose A. Godoy‐Lugo, Gilberto Garcia, Justine Silva, Minhoo Kim, Amy Christensen, Wendy J. Mack, Elizabeth Head, Peggy A. O'Day, Bérénice A. Benayoun, Todd E. Morgan, Christian J. Pike, Ryo Higuchi‐Sanabria, Henry Jay Forman, Caleb E. Finch   +14 more
wiley   +1 more source

Neurofibroma with glomus‐like bodies: A novel association—Thoughts about origin

Journal of Cutaneous Pathology, Volume 51, Issue 8, Page 594-597, August 2024.
Abstract A neurofibroma with focal glomus‐like body differentiation is an unusual phenomenon recently encountered in an excision specimen from the right lateral distal forearm of a 26‐year‐old man. Glomus cells are modified smooth muscle cells normally present in glomus‐like bodies but can also be found in glomus tumors (GT) or lesions considered in ...
Riya T. Patel, Marissa T. Rizzo, Karla C. Guerra, Douglas J. Grider   +3 more
wiley   +1 more source

THE BEGINNING OF SILVER MATURITY OF NEUROFIBRILS IN THE SPINAL CORD OF MAMMALS [PDF]

The Journal of Nervous and Mental Disease, 1909
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openaire   +2 more sources