Results 171 to 180 of about 26,212 (200)
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The Laryngoscope, 1977
AbstractFacial plexiform neurofibroma is a relatively rare manifestation of Von Recklinghausen's neurofibromatosis. Two patients with extensive facial tumor involvement are presented, each having undergone wide local resection after multiple previous local excisions had failed to control the tumor and its locally deforming and destructive effects.
R F, Smith, J M, Toomey, G G, Snyder
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AbstractFacial plexiform neurofibroma is a relatively rare manifestation of Von Recklinghausen's neurofibromatosis. Two patients with extensive facial tumor involvement are presented, each having undergone wide local resection after multiple previous local excisions had failed to control the tumor and its locally deforming and destructive effects.
R F, Smith, J M, Toomey, G G, Snyder
openaire +2 more sources
American Journal of Medical Genetics, 1999
Plexiform neurofibromas are among the most common and debilitating complications of neurofibromatosis type 1 (NF1). They account for substantial morbidity, including disfigurement, functional impairment, and may even be life threatening. Plexiform neurofibromas are also subject to transformation into malignant peripheral nerve sheath tumor (MPNST), a ...
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Plexiform neurofibromas are among the most common and debilitating complications of neurofibromatosis type 1 (NF1). They account for substantial morbidity, including disfigurement, functional impairment, and may even be life threatening. Plexiform neurofibromas are also subject to transformation into malignant peripheral nerve sheath tumor (MPNST), a ...
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Journal of Clinical Oncology
PURPOSE Pharmacologic therapies for neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PNs) are limited; currently, none are US Food and Drug Administration–approved for adults.
C. Moertel +88 more
semanticscholar +1 more source
PURPOSE Pharmacologic therapies for neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PNs) are limited; currently, none are US Food and Drug Administration–approved for adults.
C. Moertel +88 more
semanticscholar +1 more source
Neuro-Oncology
Background The MEK inhibitor, selumetinib, reduces plexiform neurofibroma (PN) in pediatric patients with neurofibromatosis type 1 (NF1). Its safety and efficacy in adults with PN and effectiveness in other NF1 manifestations (eg, neurocognitive function,
Hyery Kim +22 more
semanticscholar +1 more source
Background The MEK inhibitor, selumetinib, reduces plexiform neurofibroma (PN) in pediatric patients with neurofibromatosis type 1 (NF1). Its safety and efficacy in adults with PN and effectiveness in other NF1 manifestations (eg, neurocognitive function,
Hyery Kim +22 more
semanticscholar +1 more source
JAMA dermatology
This case report describes 4 patients with a rare autosomal dominant multisystem disorder resulting from NF1 variants that leads to café-au-lait macules and neurofibromas.
Ya-Xin Guo +6 more
semanticscholar +1 more source
This case report describes 4 patients with a rare autosomal dominant multisystem disorder resulting from NF1 variants that leads to café-au-lait macules and neurofibromas.
Ya-Xin Guo +6 more
semanticscholar +1 more source
Plexiform neurofibromas in childhood
Journal of Pediatric Surgery, 1972Abstract Sixteen cases of plexiform neurofibroma occurring in childhood have been discussed. Of lesions in the trunk or extremities, only two required multiple procedures, including a below-the-knee amputation. All patients are free of tumor at present, though they carry other stigmata of Von Recklinghausen's disease.
J, Raffensperger, R, Cohen
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Journal of dermatology (Print), 2019
Neurofibromatosis 1 (NF1) is a genetic disease characterized by cutaneous, neurological and osseous abnormalities. Approximately 20% of patients develop plexiform neurofibroma (PN), resulting in impaired quality of life.
Yuko Ehara +4 more
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Neurofibromatosis 1 (NF1) is a genetic disease characterized by cutaneous, neurological and osseous abnormalities. Approximately 20% of patients develop plexiform neurofibroma (PN), resulting in impaired quality of life.
Yuko Ehara +4 more
semanticscholar +1 more source
The Journal of craniofacial surgery (Print), 2019
Plexiform neurofibromas are common complications in neurofibromatosis type 1 patients. Currently, surgery is the treatment of choice. However, complete surgical resection is difficult due to the infiltration to the surrounding tissue and the increased ...
Jangyoun Choi +4 more
semanticscholar +1 more source
Plexiform neurofibromas are common complications in neurofibromatosis type 1 patients. Currently, surgery is the treatment of choice. However, complete surgical resection is difficult due to the infiltration to the surrounding tissue and the increased ...
Jangyoun Choi +4 more
semanticscholar +1 more source
Giant plexiform neurofibroma of thigh in a young woman
Postgraduate medical journal, 2019A 30-year-old woman presented to orthopaedic clinic with a 5-year history of severe pain and oedema of left lower limb. The patient denied experiencing any other constitutional symptoms and no history of trauma or surgery during the past years.
Shuzhong Liu +5 more
semanticscholar +1 more source