Increased CSF NFL in Non-demented Parkinson’s Disease Subjects Reflects Early White Matter Damage
Frontiers in Aging Neuroscience, 2020 Parkinson’s disease (PD) is a chronic neurodegenerative disorder with various underlying pathological processes. Until now, no fluid biomarkers have been established for PD.
Ewa Papuć, Konrad Rejdak
doaj +1 more source
Peripheral Nerve Impairment in a Mouse Model of Alzheimer’s Disease
Brain Sciences, 2021 Sarcopenia, a geriatric syndrome involving loss of muscle mass and strength, is often associated with the early phases of Alzheimer’s disease (AD). Pathological hallmarks of AD including amyloid β (Aβ) aggregates which can be found in peripheral tissues ...
Alessio Torcinaro +4 more
doaj +1 more source
Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells [PDF]
, 2017 Background: Previously, we determined that heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) functions as an intracellular physiologic sensor of folate deficiency.
Antony, Aśok C. +7 more
core +1 more source
The CRL3 gigaxonin ubiquitin ligase–USP15 pathway governs the destruction of neurofilament proteins [PDF]
, 2023 Hyoung-Min Park +6 more
openalex +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Neural tube-ectoderm interactions are required for trigeminal placode formation [PDF]
, 1997 Cranial sensory ganglia in vertebrates develop from the ectodermal placodes, the neural crest, or both. Although much is known about the neural crest contribution to cranial ganglia, relatively little is known about how placode cells form, invaginate and
Bronner-Fraser, Marianne +3 more
core
Plasma glial fibrillary acidic protein, neurofilament light, phosphorylated‐tau‐181 and amyloid β42/40 as prognostic biomarkers for clinical progression to dementia in individuals with subjective cognitive decline and mild cognitive impairment [PDF]
, 2022 Madison I. J. Honey +12 more
openalex +1 more source
Brain : a journal of neurology, 2018 Neuro-axonal injury is a key factor in the development of permanent disability in multiple sclerosis. Neurofilament light chain in peripheral blood has recently emerged as a biofluid marker reflecting neuro-axonal damage in this disease.
Christian Barro +14 more
semanticscholar +1 more source
Increased Blood Levels of NfL, GFAP, and Placental Growth Factor After Radiotherapy to the Brain
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT In this study, we analyzed biomarkers of neuronal, glial, and vascular injury in longitudinal paired samples of blood and cerebrospinal fluid after prophylactic cranial irradiation in patients with small cell lung cancer. Neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAP) increased in serum and cerebrospinal ...
Erik Fernström +5 more
wiley +1 more source
Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence [PDF]
, 1996 Enteric and sympathetic neurons have previously been proposed to be lineally related. We present independent lines of evidence that suggest that enteric neurons arise from at least two lineages, only one of which expresses markers in common with ...
Anderson, D. J. +6 more
core