Results 141 to 150 of about 102,686 (380)

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier. [PDF]

, 2015
The dynamic adjustment of hearing sensitivity and frequency selectivity is mediated by the medial olivocochlear efferent reflex, which suppresses the gain of the 'cochlear amplifier' in each ear.
Cederholm, Jennie ME, Froud, Kristina E, Housley, Gary D, Julien, Jean-Pierre, Klugmann, Matthias, Ryan, Allen F, Sandow, Shaun L, Wong, Ann Chi Yan   +7 more
core   +2 more sources

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Neurofilament light chain as a biomarker for acute hepatic porphyrias

Frontiers in Neurology
BackgroundAcute hepatic porphyrias (AHP) represent a rare group of inherited metabolic disorders of heme biosynthesis pathway. This study aims to determine the diagnostic and prognostic value of serum neurofilament light chain (NfL) as potential ...
Paulo Sgobbi, Paulo de Lima Serrano, Bruno de Mattos Lombardi Badia, Igor Braga Farias, Hélvia Bertoldo de Oliveira, Alana Strucker Barbosa, Camila Alves Pereira, Vanessa de Freitas Moreira, Ícaro França Navarro Pinto, Acary Souza Bulle Oliveira, Wladimir Bocca Vieira de Rezende Pinto   +10 more
doaj   +1 more source

The role of neurofilament transport in the radial growth of myelinated axons [PDF]

, 2023
Rawan M. Nowier, Anika Friedman, Anthony Brown, Peter Jung   +3 more
openalex   +1 more source

Diffusion‐MRI‐Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains

Advanced Science, EarlyView.
We present Diffusion‐MRI‐based Estimation of Cortical Architecture via Machine Learning (DECAM), a deep‐learning framework for estimating primate brain cortical architecture optimized with best response constraint and cortical label vectors. Trained using macaque brain high‐resolution multi‐shell dMRI and histology data, DECAM generates high‐fidelity ...
Tianjia Zhu, Minhui Ouyang, Shufang Tan, Jianlin Guo, Ziqin Zhang, Xuan Liu, Risheng Liu, Hao Huang   +7 more
wiley   +1 more source

The Association of Axonal Damage Biomarkers and Osteopontin at Diagnosis Could Be Useful in Newly Diagnosed MS Patients

Neurology International
(1) Background: Multiple sclerosis (MS) is a biologically highly heterogeneous disease and has poor predictability at diagnosis. Moreover, robust data indicate that early disease activity strongly correlates with future disability.
Eleonora Virgilio, Chiara Puricelli, Nausicaa Clemente, Valentina Ciampana, Ylenia Imperatore, Simona Perga, Sveva Stangalini, Elena Boggio, Alice Appiani, Casimiro Luca Gigliotti, Umberto Dianzani, Cristoforo Comi, Domizia Vecchio   +12 more
doaj   +1 more source

Serum neurofilament light chain levels at attack predict post-attack disability worsening and are mitigated by inebilizumab: analysis of four potential biomarkers in neuromyelitis optica spectrum disorder [PDF]

, 2023
Orhan Aktaş, Hans‐Peter Hartung, Michael Smith, William A. Rees, Kazuo Fujihara, Friedemann Paul, Romain Marignier, Jeffrey L. Bennett, Ho Jin Kim, Brian G. Weinshenker, Sean J. Pittock, Dean M. Wingerchuk, Gary Cutter, Dewei She, Michele Gunsior, Daniel Cimbora, Eliezer Katz, Bruce Cree   +17 more
openalex   +1 more source

Neurofilament Light Chain as a Biomarker in Multiple Sclerosis

Frontiers in Neurology, 2019
Due to the unpredictable course and heterogenous treatment response in multiple sclerosis (MS), there is a clear need for biomarkers that reflect disease activity in the clinical follow-up of these patients.
K. N. Varhaug, Ø. Torkildsen, K. Myhr, C. Vedeler   +3 more
semanticscholar   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source