Results 161 to 170 of about 65,054 (212)
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Neurofilaments and neurological disease
BioEssays, 2003AbstractNeurofilaments are one of the major components of the neuronal cytoskeleton and are responsible for maintaining the calibre of axons. They are modified by post‐translational changes that are regulated in complex fashions including by the interaction with neighbouring glial cells.
Al-Chalabi, A, Miller, C C J
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Annals of the New York Academy of Sciences, 2009
Immune responses to neuronal proteins are a frequent occurrence in neurodegenerative diseases. This study determines the occurrence of autoantibodies to the three neurofilament subunits in phosphorylated and dephosphorylated forms and relates these measures to age, human leukocyte antigen (HLA), and severity of disease in Down syndrome (DS).
Ija Talja +7 more
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Immune responses to neuronal proteins are a frequent occurrence in neurodegenerative diseases. This study determines the occurrence of autoantibodies to the three neurofilament subunits in phosphorylated and dephosphorylated forms and relates these measures to age, human leukocyte antigen (HLA), and severity of disease in Down syndrome (DS).
Ija Talja +7 more
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Neurofilaments in Health and Disease
1998This article reviews current knowledge of neurofilament structure, phosphorylation, and function and neurofilament involvement in disease. Neurofilaments are obligate heteropolymers requiring the NF-L subunit together with either the NF-M or the NF-H subunit for polymer formation. Neurofilaments are very dynamic structures; they contain phosphorylation
J P, Julien, W E, Mushynski
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Overexpression of neurofilament subunit M accelerates axonal transport of neurofilaments
Brain Research, 2000Neurofilaments are composed of three polypeptide subunits (NF-H, NF-M and NF-L). They are the most abundant cytoskeletal element in large myelinated axons and play a central role in development of axonal caliber. To perform this role, neurofilaments are transported from their site of synthesis, the cell bodies, to the distal axons.
Z, Xu, V W, Tung
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Neurofilaments in neurologic disorders and beyond
Journal of the Neurological Sciences, 2022Many neurologic diseases can initially present as a diagnostic challenge and even when a diagnosis is made, monitoring of disease activity, progression and response to therapy may be limited with existing clinical and paraclinical assessments. As such, the identification of disease specific biomarkers provides a promising avenue by which diseases can ...
Gloria, Mak +2 more
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NEUROFILAMENT ANTIGENS IN ACRYLAMIDE NEUROPATHY.
Journal of Neuropathology and Experimental Neurology, 1987After repeated exposure, acrylamide (AC) produces degeneration of distal axons. Because neurons whose axons have been injured (e.g. by axotomy) show alterations in their structural and chemical properties, the present study was designed to differentiate the direct effects of AC intoxication from neuronal responses secondary to axonal injury caused by ...
B G, Gold +6 more
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On the assembly mechanism of neurofilaments
International Journal of Biochemistry, 19901. Isolated individual components of the triplet of neurofilaments from bovine brain can reassemble to make filaments with a specific structure, contrary to the already reported result that NF-H and NF-M cannot make filaments alone but can only make filaments by co-polymerization with NF-L. 2.
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Neurofilaments in diabetic neuropathy
2002This review discusses the role of abnormal neurofilament (NF) expression, processing, and structure as an etiological factor in diabetic neuropathy. Diabetic sensory and autonomic neuropathy in humans is associated with a spectrum of structural changes in peripheral nerve that includes axonal degeneration, paranodal demyelination, and loss of ...
Paul, Fernyhough, Robert E, Schmidt
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Neurofilaments in health and disease
Medical Electron Microscopy, 2000With dendritic neurofilaments (NFs) and NF reassembly experiments, the phosphorylation of NF-H was found related to development of crossbridges, resulting in alignment of core filaments. When treated with aluminum chloride, rabbits died acutely with tetanic spasm in which NFs were accumulated in neuronal perikarya and proximal axons.
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Neurofilaments and glial filaments
Tissue and Cell, 1970The structure of neurofilaments and glial filaments are compared. Both filaments are composed of three subunits-a globule, interconnecting crossbar and side-arms. These elements form a tubular arrangement and their dimensions are given. Since the subunits of both filaments have a similar arrangement but differ in size, it is concluded that they ...
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