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Expanded Polyglutamine Domain Proteins Bind Neurofilament and Alter the Neurofilament Network
Experimental Neurology, 1999Eight inherited neurodegenerative diseases are caused by genes with expanded CAG repeats coding for polyglutamine domains in the disease-producing proteins. The mechanism by which this expanded polyglutamine domain causes neurodegenerative disease is unknown, but nuclear and cytoplasmic polyglutamine protein aggregation is a common feature.
Y, Nagai +4 more
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Journal of Molecular Biology, 2009
Neurofilaments (NFs) are essential cytoskeletal filaments that impart mechanical integrity to nerve cells. They are assembled from three distinct molecular mass proteins that bind to each other to form a 10-nm-diameter filamentous rod with sidearm extensions.
Rakwoo, Chang +2 more
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Neurofilaments (NFs) are essential cytoskeletal filaments that impart mechanical integrity to nerve cells. They are assembled from three distinct molecular mass proteins that bind to each other to form a 10-nm-diameter filamentous rod with sidearm extensions.
Rakwoo, Chang +2 more
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Journal of Neurochemistry, 1982
Abstract: The possibility that neurofilaments could be involved in the transduction of chemical and mechanical energy in axons led us to investigate whether neurofilament proteins can hydrolyze ATP. We fractionated neurofilaments from rabbit spinal cord and found that preparations highly enriched for neurofilament proteins hydrolyzed ATP at a ...
M A, Glicksman, M, Willard
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Abstract: The possibility that neurofilaments could be involved in the transduction of chemical and mechanical energy in axons led us to investigate whether neurofilament proteins can hydrolyze ATP. We fractionated neurofilaments from rabbit spinal cord and found that preparations highly enriched for neurofilament proteins hydrolyzed ATP at a ...
M A, Glicksman, M, Willard
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The Journal of Biochemistry, 1982
Interaction between porcine brain tubulin and neurofilaments was investigated with reference to network formation in vitro. When a mixture of tubulin and neurofilaments was incubated at 33--34 degrees C, its low-shear viscosity measured with a falling ball viscometer, was far above the sum of viscosities of the separate components and gelation was ...
Y, Minami, H, Murofushi, H, Sakai
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Interaction between porcine brain tubulin and neurofilaments was investigated with reference to network formation in vitro. When a mixture of tubulin and neurofilaments was incubated at 33--34 degrees C, its low-shear viscosity measured with a falling ball viscometer, was far above the sum of viscosities of the separate components and gelation was ...
Y, Minami, H, Murofushi, H, Sakai
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Neurofilaments in neurologic disease
Neurofilaments (NFs), major cytoskeletal constituents of neurons, have emerged as universal biomarkers of neuronal injury. Neuroaxonal damage underlies permanent disability in various neurological conditions. It is crucial to accurately quantify and longitudinally monitor this damage to evaluate disease progression, evaluate treatment effectiveness ...Christina, Mousele +2 more
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