Results 171 to 180 of about 102,686 (380)

Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer’s disease

Alzheimer's Research & Therapy, 2018
BackgroundA growing body of evidence suggests that the plasma concentration of the neurofilament light chain (NfL) might be considered a plasma biomarker for the screening of neurodegeneration in Alzheimer’s disease (AD).MethodsWith a single molecule ...
P. Lewczuk, Natalia Ermann, U. Andreasson, C. Schultheis, J. Podhorná, P. Spitzer, J. Maler, J. Kornhuber, K. Blennow, H. Zetterberg   +9 more
semanticscholar   +1 more source

Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study

Annals of Neurology, EarlyView.
Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai, Joanne Wuu, Magdalena Koziczak‐Holbro, Andrea Malaspina, Volkan Granit, Jessica P. Hernandez, Anne Cooley, Ruchika Sachdev, Lili Yu, Michael Bidinosti, Ludivine Flotte, Mark Nash, Lori L. Jennings, James D. Berry, Lucie I. Bruijn, Sophie Brachat, Michael Benatar   +16 more
wiley   +1 more source

Circulating neurofilaments to track dorsal root ganglion toxicity risks with AAV-mediated gene therapy

Molecular Therapy: Methods & Clinical Development, 2022
Michelle A. Farrar, Ewout Groen, Christiano Alves   +2 more
doaj   +1 more source

From Diagnosis to Disease Staging: Multisite Validation of Cerebrospinal Fluid Molecular Tests in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective The growing demand for personalized treatment in multiple sclerosis (MS) highlights the need for more precise biomarkers that can outperform magnetic resonance imaging and clinical assessment in patient stratification. Advances in multiplex proteomic technologies suggest that cerebrospinal fluid (CSF) analysis at MS onset may not only improve
Laura Ghezzi, Peter Kosa, Mark Greenwood, Enrique Alvarez, C.L. Freedman, Anne H. Cross, Francesca Pace, Mark S. Freedman, Joanna Kocot, Laura Piccio, Bibiana Bielekova   +10 more
wiley   +1 more source

Plasma neurofilament light is a predictor of neurological outcome 12 h after cardiac arrest [PDF]

, 2023
Helena Levin, Anna Lybeck, Attila Frigyesi, Isabelle Arctaedius, Bergþóra Þorgeirsdóttir, Martin Annborn, Marion Moseby‐Knappe, Niklas Nielsen, Tobias Cronberg, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Hans Friberg, Niklas Mattsson   +13 more
openalex   +1 more source

Combination of Serum Neurofilament Light Chain and Serum Cardiac Troponin T as Biomarkers Improves Diagnostic Accuracy in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective We aimed to evaluate the clinical utility of serum neurofilament light chain (sNfL) and cardiac troponin T (cTnT) in amyotrophic lateral sclerosis (ALS) and assess whether their combination improves diagnostic accuracy. Methods We retrospectively analyzed 293 ALS patients, 85 neurodegenerative disease controls, and 29 healthy controls.
Paula Lindenborn, Rachel Fabian, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Sarah Bernsen, Patrick Weydt   +6 more
wiley   +1 more source

Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease

, 2020
Filipe B. Rodrigues, Lauren M. Byrne, Rosanna Tortelli, Eileanoir B. Johnson, P. A. Wijeratne, Marzena Arridge, Enrico De Vita, Naghmeh Ghazaleh, Richard Houghton, Hannah Furby, Daniel C. Alexander, Sarah J. Tabrizi, Scott Schobel, Rachael I. Scahill, Amanda Heslegrave, Henrik Zetterberg, Edward J. Wild   +16 more
openalex   +2 more sources

Serum neurofilament light chain in behavioral variant frontotemporal dementia [PDF]

, 2018
Petra Steinacker, Sarah Anderl‐Straub, Janine Diehl‐Schmid, Elisa Semler, Ingo Uttner, Christine A. F. Von Arnim, Henryk Barthel, Adrian Danek, Klaus Faßbender, Klaus Fließbach, Hans Foerstl, Timo Grimmer, Hans‐Jürgen Huppertz, Holger Jahn, Jan Kassubek, Johannes Kornhuber, G. Bernhard Landwehrmeyer, Martin Lauer, Juan Manuel Maler, Benjamin Mayer, Patrick Oeckl, Johannes Prudlo, Anja Schneider, Alexander E. Volk, Jens Wiltfang, Matthias L. Schroeter, Albert C. Ludolph, Markus Otto, Franziska Albrecht, Sandrine Bisenius, Emily Feneberg, Sibylle Haefner, Elisabeth Kasper, Delia Kurzwelly, Leonie Lampe, Johannes Levin, Finn Lornsen, Maxine Luley, Timo Jan Oberstein, Hannah Pellkofer, Catharina Prix, Tanja Richter‐Schmidinger, Nina Roth, Osama Sabri, Lisa Schachner, Robert Schomburg, Sonja Schönecker, Katharina Schuemberg, Annika Spottke, Stefan Teipel, Petra Wilken, Heike Zech, Heike Zech   +52 more
openalex   +1 more source

The Epidemiology of Primary Lateral Sclerosis: Results from a Population‐Based Cohort

Annals of Neurology, EarlyView.
Objective In this population‐based study, we described the epidemiology of primary lateral sclerosis (PLS) in northern Italy and compared the clinical characteristics of patients with PLS to those with predominant upper motor neuron (PUMN) involvement and classic amyotrophic lateral sclerosis (ALS).
Rosario Vasta, Enrico Matteoni, Giorgio Pellegrino, Antonio Canosa, Umberto Manera, Francesca Palumbo, Maurizio Grassano, Sara Cabras, Alessandra Maccabeo, Fabrizio D'Ovidio, Gabriele Mora, Salvatore Gallone, Elisa D'Angelo, Letizia Mazzini, Fabiola De Marchi, Cristina Moglia, Adriano Chiò, Andrea Calvo   +17 more
wiley   +1 more source

Segmental migration of trunk neural crest: time-lapse analysis reveals a role for PNA-binding molecules [PDF]

, 1995
Trunk neural crest cells migrate through the somites in a striking segmental fashion, entering the rostral but not caudal sclerotome, via cues intrinsic to the somites.
Bronner-Fraser, Marianne, Collazo, Andres, Fraser, Scott E., Krull, Catherine E.   +3 more
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