Results 1 to 10 of about 28,422 (244)

Current application of neurofilaments in amyotrophic lateral sclerosis and future perspectives

Neural Regeneration Research, 2021
Motor neuron disease includes a heterogeneous group of relentless progressive neurological disorders defined and characterized by the degeneration of motor neurons.
Yuri Matteo Falzone, Tommaso Russo, Teuta Domi, Laura Pozzi, Angelo Quattrini, Massimo Filippi, Nilo Riva   +6 more
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Age-related dynamics of morphological changes in the human cortex and corpus callosum: Microgliocytes and neurofilaments as markers of aging [PDF]

Наука и инновации в медицине, 2021
Objectives to analyze the number and sum of diameters of microgliocytes in the precentral gyrus cortex and the corpus callosum of a person in the early adulthood and of an old person and to identify the patterns of neurofilaments expression in these ...
Anatolii A. Balandin, Lev M. Zheleznov, Irina A. Balandina, Vladimir A. Balandin   +3 more
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A Stochastic Multiscale Model That Explains the Segregation of Axonal Microtubules and Neurofilaments in Neurological Diseases. [PDF]

PLoS Computational Biology, 2015
The organization of the axonal cytoskeleton is a key determinant of the normal function of an axon, which is a long thin projection of a neuron.
Chuan Xue, Blerta Shtylla, Anthony Brown
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Multidimensional overview of neurofilament light chain contribution to comprehensively understanding multiple sclerosis

Frontiers in Immunology, 2022
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease characterized by demyelination, progressive axonal loss, and varying clinical presentations.
Rodolfo A. Kölliker Frers, Rodolfo A. Kölliker Frers, Matilde Otero-Losada, Tamara Kobiec, Tamara Kobiec, Lucas D. Udovin, María Laura Aon Bertolino, María I. Herrera, María I. Herrera, Francisco Capani, Francisco Capani   +10 more
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The diagnostic significance of neurofilament heavy chains in cerebrospinal fluid in amyotrophic lateral sclerosis

Анналы клинической и экспериментальной неврологии, 2021
Introduction. Early diagnosis of amyotrophic lateral sclerosis (ALS) is difficult because of the low sensitivity of clinical criteria at the early stages of the disease and the lack of reliable laboratory biomarkers.
Anastasia V. Vladykina, Vladimir D. Nazarov, Vladimir S. Krasnov, Ekaterina I. Koroleva, Polina A. Fedorova, Anna N. Moshnikova, Aleksandra V. Mazing, Sergey V. Lapin, Vladimir L. Emanuel, Dmitriy I. Rudenko, Fatima R. Stuchevskaya, Sergey M. Zatakovenko, Tatyana A. Pavlova, Tatyana M. Alekseeva, Vitaliy V. Goldobin   +14 more
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Density of SMI-32 Immunopositive Neurons in Eye-Specific Layers of Lateral Geniculate Nuclei in Kittens Reared with Monocular Deprivation and Unilateral Convergent Squint

Medical Sciences Forum, 2021
To reveal the dynamics of the development of the morphological changes in lateral geniculate nuclei caused by binocular vision impairment, we study the changes in density of SMI-32 immunopositive neurons in the frontal sections of the LGNd of both ...
Polina Y. Shkorbatova, Vsevolod A. Lyakhovetskii, Svetlana V. Alexeenko   +2 more
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Association of Serum GFAP with Functional and Neurocognitive Outcome in Sporadic Small Vessel Disease

Biomedicines, 2022
Cerebrospinal fluid (CSF) and serum biomarkers are critical for clinical decision making in neurological diseases. In cerebral small vessel disease (CSVD), white matter hyperintensities (WMH) are an important neuroimaging biomarker, but more blood-based ...
André Huss, Ahmed Abdelhak, Benjamin Mayer, Hayrettin Tumani, Hans-Peter Müller, Katharina Althaus, Jan Kassubek, Markus Otto, Albert C. Ludolph, Deniz Yilmazer-Hanke, Hermann Neugebauer   +10 more
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Changes in pNFH Levels in Cerebrospinal Fluid and Motor Evolution after the Loading Dose with Nusinersen in Different Types of Spinal Muscular Atrophy

Medicina, 2023
Aim and Objectives: The objective of our retrospective study was to investigate the changes in pNFH levels in cerebrospinal fluid, which is a reliable marker of neuronal damage, after the loading dose of nusinersen in different types of spinal muscular ...
Mihaela Badina, Gabriel Cristian Bejan, Corina Sporea, Liliana Padure, Andrada Mirea, Madalina-Cristina Leanca, Mihaela Axente, Florin Petru Grigoras, Mihaela Bejan, Elena-Silvia Shelby, Elena Neagu, Daniela Adriana Ion   +11 more
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Role of Blood Neurofilaments in the Prognosis of Amyotrophic Lateral Sclerosis: A Meta-Analysis

Frontiers in Neurology, 2021
Background: Neurofilaments in cerebrospinal fluid (CSF) and in blood are considered promising biomarkers of amyotrophic lateral sclerosis (ALS) because their levels can be significantly increased in patients with ALS. However, the roles of neurofilaments,
Yan-ni Zhou, Yan-ni Zhou, You-hong Chen, Si-qi Dong, Wen-bo Yang, Ting Qian, Xiao-ni Liu, Qi Cheng, Jiu-cun Wang, Jiu-cun Wang, Xiang-jun Chen, Xiang-jun Chen   +11 more
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Neurofilament ELISA validation [PDF]

Journal of Immunological Methods, 2010
Neurofilament proteins (Nf) are highly specific biomarkers for neuronal death and axonal degeneration. As these markers become more widely used, an inter-laboratory validation study is required to identify assay criteria for high quality performance.The UmanDiagnostics NF-light (R)enzyme-linked immunoabsorbent assays (ELISA) for the neurofilament light
Petzold, A., Altintas, A., Andreoni, L., Bartos, A., Berthele, A., Blankenstein, M.A., Buee, L., Castellazzi, M., Cepok, S., Comabella, M., Constantinescu, C.S., Deisenhammer, F., Deniz, G., Erten, G., Espino, M., Fainardi, E., Franciotta, D., Freedman, M.S., Giedraitis, V., Gilhus, N.E., Giovannoni, G., Glabinski, A., Grieb, P., Hartung, H.P., Hemmer, B., Herukka, S.K., Hintzen, R., Ingelsson, M., Jackson, S., Jacobsen, S., Jafari, N., Jalosinski, M., Jarius, S., Kapaki, E., Kieseier, B.C., Koel-Simmelink, M.J., Kornhuber, J., Kuhle, J., Kurzepa, J., Lalive, P.H., Lannfelt, L., Lehmensiek, V., Lewczuk, P., Livrea, P., Marnetto, F., Martino, D., Menge, T., Norgren, N., Papuc, E., Paraskevas, G.P., Pirttilä, T., Rajda, C., Rejdak, K., Ricny, J., Ripova, D., Rosengren, L., Ruggieri, M., Schraen, S., Shaw, G., Sindic, C., Siva, A., Stigbrand, T., Stonebridge, I., Topcular, B., Trojano, M., Tumani, H., Twaalfhoven, H.A., Vecsei, L., Van Pesch, V., Vanderstichele, H., Vedeler, C., Verbeek, M.M., Verbeek, M.M., Villar, L.M., Weissert, R., Wildemann, B., Yang, C., Yao, K., Teunissen, C.E.   +78 more
openaire   +10 more sources