Results 1 to 10 of about 65,054 (212)

Neurofilament ELISA validation [PDF]

Journal of Immunological Methods, 2010
Neurofilament proteins (Nf) are highly specific biomarkers for neuronal death and axonal degeneration. As these markers become more widely used, an inter-laboratory validation study is required to identify assay criteria for high quality performance.The UmanDiagnostics NF-light (R)enzyme-linked immunoabsorbent assays (ELISA) for the neurofilament light
Petzold, A., Altintas, A., Andreoni, L., Bartos, A., Berthele, A., Blankenstein, M.A., Buee, L., Castellazzi, M., Cepok, S., Comabella, M., Constantinescu, C.S., Deisenhammer, F., Deniz, G., Erten, G., Espino, M., Fainardi, E., Franciotta, D., Freedman, M.S., Giedraitis, V., Gilhus, N.E., Giovannoni, G., Glabinski, A., Grieb, P., Hartung, H.P., Hemmer, B., Herukka, S.K., Hintzen, R., Ingelsson, M., Jackson, S., Jacobsen, S., Jafari, N., Jalosinski, M., Jarius, S., Kapaki, E., Kieseier, B.C., Koel-Simmelink, M.J., Kornhuber, J., Kuhle, J., Kurzepa, J., Lalive, P.H., Lannfelt, L., Lehmensiek, V., Lewczuk, P., Livrea, P., Marnetto, F., Martino, D., Menge, T., Norgren, N., Papuc, E., Paraskevas, G.P., Pirttilä, T., Rajda, C., Rejdak, K., Ricny, J., Ripova, D., Rosengren, L., Ruggieri, M., Schraen, S., Shaw, G., Sindic, C., Siva, A., Stigbrand, T., Stonebridge, I., Topcular, B., Trojano, M., Tumani, H., Twaalfhoven, H.A., Vecsei, L., Van Pesch, V., Vanderstichele, H., Vedeler, C., Verbeek, M.M., Verbeek, M.M., Villar, L.M., Weissert, R., Wildemann, B., Yang, C., Yao, K., Teunissen, C.E.   +78 more
openaire   +14 more sources

Neurofilament phosphorylation

Biochemistry and Cell Biology, 1995
Neurofilament proteins (NFPs) are highly phosphorylated molecules in the axonal compartment of the adult nervous system. The phosphorylation of NFP is considered an important determinant of filament caliber, plasticity, and stability. This process reflects the function of NFs during the lifetime of a neuron from differentiation in the embryo through ...
H C, Pant, , Veeranna
openaire   +3 more sources

Early neuro biomarker changes and electrophysiological nerve dysfunction in Swedish V50M hereditary transthyretin amyloidosis: a pilot study [PDF]

Frontiers in Neurology
BackgroundThis exploratory pilot study aimed to evaluate serum levels of neurofilament light chain (NfL), peripherin (PRPH), and glial fibrillary acidic protein (GFAP), and to explore their potential associations with nerve conduction studies (NCS) and ...
Sandra Arvidsson, Sandra Arvidsson, Intissar Anan, Malin Olsson, Victoria Heldestad, Victoria Heldestad   +5 more
doaj   +2 more sources

Loss and recovery of neurofilament in the cat lateral geniculate nucleus following monocular retinal inactivation [PDF]

Frontiers in Neuroscience
BackgroundPostnatal development of the mammalian primary visual pathway occurs early in life and is guided by visually-driven afferent activity. Even a short duration of disrupted binocular vision can derail development of neural connections and produce ...
Andrea De Paola, Robert W. Jones, Jonathon M. Henneberry, Kevin R. Duffy   +3 more
doaj   +2 more sources

Cerebrospinal fluid level of phosphorylated neurofilament heavy chain is higher in converting clinically isolated syndrome and correlates with CAMP response element-binding protein concentration

Neurological Sciences and Neurophysiology, 2021
Introduction: Prevision of conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) is required to avoid unnecessary use of immunomodulating agents and to recognize patients with high disease activity.
Mehmet Gencer, Gizem Koral, Elif Sanli, Selen Cirak, Ece Akbayir, Hande Yuceer, Tugce Kizilay, Ruziye Erol Yildiz, Sibel Penbe Yentur, Vuslat Yilmaz, Erdem Tuzun, Recai Turkoglu   +11 more
doaj   +1 more source

Case Report: Successful Stabilization of Marburg Variant Multiple Sclerosis With Ocrelizumab Following High-Dose Cyclophosphamide Rescue

Frontiers in Neurology, 2021
The Marburg variant of multiple sclerosis (Marburg MS) is the most aggressive form of MS, often leading to death soon after onset. Here we describe the case of a 26-year-old Marburg MS patient presenting with severe neurological deficits requiring ...
Valeria Koska, Moritz Förster, Katja Brouzou, Maryam Hatami, Ercan Arat, Ahmet Aytulun, Philipp Albrecht, Orhan Aktas, Patrick Küry, Sven G. Meuth, David Kremer   +10 more
doaj   +1 more source

Role of Blood Neurofilaments in the Prognosis of Amyotrophic Lateral Sclerosis: A Meta-Analysis

Frontiers in Neurology, 2021
Background: Neurofilaments in cerebrospinal fluid (CSF) and in blood are considered promising biomarkers of amyotrophic lateral sclerosis (ALS) because their levels can be significantly increased in patients with ALS. However, the roles of neurofilaments,
Yan-ni Zhou, Yan-ni Zhou, You-hong Chen, Si-qi Dong, Wen-bo Yang, Ting Qian, Xiao-ni Liu, Qi Cheng, Jiu-cun Wang, Jiu-cun Wang, Xiang-jun Chen, Xiang-jun Chen   +11 more
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Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis

Frontiers in Neurology, 2022
In amyotrophic lateral sclerosis (ALS), neurodegeneration is characterized by distal axonopathy that begins at the distal axons, including the neuromuscular junctions, and progresses proximally in a “dying back” manner prior to the degeneration of cell ...
Yuko Kawamoto, Yuko Kawamoto, Mikiko Tada, Tetsuya Asano, Haruko Nakamura, Aoi Jitsuki-Takahashi, Hiroko Makihara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Toshio Ohshima, Yoshio Goshima, Hideyuki Takeuchi, Hiroshi Doi, Fumio Nakamura, Fumiaki Tanaka   +15 more
doaj   +1 more source

Tau phosphorylation and cochlear apoptosis cause hearing loss in 3×Tg-AD Mouse Model of Alzheimer's Disease

Chinese Journal of Physiology, 2021
Clinically typical dementia Alzheimer's disease (AD) is associated with abnormal auditory processing. However, possible molecular mechanisms responsible for the auditory pathology of AD patients are not known. According to our past research findings that
Sheue-Er Wang, Chung-Hsin Wu
doaj   +1 more source

Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies

Frontiers in Neuroscience, 2021
Biomarkers of neurodegeneration and neuronal injury have the potential to improve diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy.
Aidong Yuan, Aidong Yuan, Ralph A. Nixon, Ralph A. Nixon, Ralph A. Nixon   +4 more
doaj   +1 more source