Results 41 to 50 of about 65,054 (212)
SARM1 Depletion Slows Axon Degeneration in a CNS Model of Neurotropic Viral Infection
Frontiers in Molecular Neuroscience, 2022 Zika virus (ZIKV) is a neurotropic flavivirus recently linked to congenital ZIKV syndrome in children and encephalitis and Guillain-Barré syndrome in adults. Neurotropic viruses often use axons to traffic to neuronal or glial cell somas where they either
Colin L. Crawford +13 more
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Neurofilament light chain as biomarker in idiopathic intracranial hypertension [PDF]
, 2020 Background: Damage of the optic nerve is the major complication of idiopathic intracranial hypertension. A biomarker indicative for optic nerve damage would help identifying high-risk patients requiring surgical procedures. Here, we studied the potential
Beier, Dagmar +11 more
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Retinal and Optic Nerve Integrity Following Monocular Inactivation for the Treatment of Amblyopia
Frontiers in Systems Neuroscience, 2020 In animal models, monocular deprivation (MD) by lid closure mimics the effects of unilateral amblyopia in humans. Temporary inactivation of one or both eyes with intraocular administration of tetrodotoxin (TTX) has recently been shown to promote recovery
Nadia R. DiCostanzo +3 more
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Frontiers in Psychiatry, 2023 IntroductionNeurofilament light chain protein (NfL) is a fluid biomarker of neural injury measurable in cerebrospinal fluid and blood. Patients with different neurodegenerative disorders and mild traumatic brain injury display elevated levels of NfL ...
Anja Fernqvist +16 more
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Avidity of antineurocytoskeletal antibodies in Alzheimer's disease patients
Biomedical Papers, 2017 Aims: To optimise the ELISA method for the avidity of IgG antibodies against neurofilament heavy chain (NfH) and to determine the levels and avidity of anti-NfH antibodies in patients with Alzheimer's disease (AD) and a healthy control group.
Libuse Noskova +3 more
doaj +1 more source
Expression of the cellular prion protein by mast cells in the human carotid body
Prion, 2023 Prion diseases are fatal neurologic disorders that can be transmitted by blood transfusion. The route for neuroinvasion following exposure to infected blood is not known.
Gregory D. Sweetland +4 more
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Circulating Biomarkers in Neuromuscular Disorders: What Is Known, What Is New
Biomolecules, 2021 The urgent need for new therapies for some devastating neuromuscular diseases (NMDs), such as Duchenne muscular dystrophy or amyotrophic lateral sclerosis, has led to an intense search for new potential biomarkers.
Andrea Barp +4 more
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ChildrenRisdiplam is an orally administered small molecule that modifies the mRNA splicing of SMN2 for the treatment of spinal muscular atrophy (SMA). Its use is approved in presymptomatic patients diagnosed by neonatal screening with early and severe forms with
Inmaculada Pitarch-Castellano +5 more
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Frontiers in NeurologyObjectiveTo investigate the associations between several laboratory parameters and plasma neurofilament light chain (pNfL) in individuals with multiple sclerosis (MS), as well as their additional contribution to the established relationships between pNfL,
Valerio Nicolella +22 more
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Neurofilaments in health and Charcot-Marie-Tooth disease
Frontiers in Cell and Developmental Biology, 2023 Neurofilaments (NFs) are the most abundant component of mature neurons, that interconnect with actin and microtubules to form the cytoskeleton. Specifically expressed in the nervous system, NFs present the particularity within the Intermediate Filament ...
Farah Kotaich +2 more
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