Results 21 to 30 of about 65,054 (212)

Exploring Neurofilament Light Chain and Exosomes in the Genetic Forms of Frontotemporal Dementia

Frontiers in Neuroscience, 2022
Differential diagnosis of neurological disorders and their subtype classification are challenging without specific biomarkers. Genetic forms of these disorders, typified by an autosomal dominant family history, could offer a window to identify potential ...
Roberta Zanardini, Claudia Saraceno, Luisa Benussi, Rosanna Squitti, Roberta Ghidoni   +4 more
doaj   +1 more source

Plasma Neurofilament Heavy Chain Levels Correlate to Markers of Late Stage Disease Progression and Treatment Response in SOD1(G93A) Mice that Model ALS [PDF]

, 2012
Background: Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder characterised by progressive degeneration of motor neurons leading to death, typically within 3–5 years of symptom onset. The diagnosis of ALS is largely reliant
Greensmith Linda, Dick, J, Petzold, A, Linda Greensmith, Malaspina Andrea, Petzold Axel, Greensmith, L, Kalmar Bernadett, Kalmar, B, Dick James, Lu Ching-Hua, Lu, CH, Bernadett Kalmar, James Dick, Ching-Hua Lu, Lu, C-H, Andrea Malaspina, Malaspina, A, Axel Petzold   +18 more
core   +2 more sources

Phosphorylation-dependent neurofilament epitopes are reduced at the node of Ranvier [PDF]

, 1992
Neurofilaments in axons are highly phosphorylated at multiple sites on the 200 kDa neurofilament (neurofilament-H) and 160 kDa (neurofilament-M) subunit peptides.
Mata, Marina, Fink, David J., Kupina, Nancy C.   +2 more
core   +1 more source

Astroblastoma-like glioma, EWSR1-BEND2 fused #1 neurofilament

, 2021
neurofilament immunostain from case #
David Solomon (4497931)
core   +1 more source

Changes in Neurofilament and Microtubule Distribution following Focal Axon Compression [PDF]

, 2015
Although a number of cytoskeletal derangements have been described in the setting of traumatic axonal injury (TAI), little is known of early structural changes that may serve to initiate a cascade of further axonal degeneration.
Ramesh, K.T., Shrestha, S., Hogan, J.D., Fournier, A.J., Rajbhandari, L., Venkatesan, A.   +5 more
core   +1 more source

Extra Axonal Neurofilaments Do Not Exacerbate Disease Caused by Mutant Cu,Zn Superoxide Dismutase

Neurobiology of Disease, 2000
A recent report by T. L. Williamson et al. (1998, Proc. Natl. Acad. Sci. USA 95, 9631–9636) showed that disease caused by expression of mutant Cu,Zn superoxide dismutase (SOD1) in mice was slowed down by disruption of the neurofilament light (NF-L) gene.
Sébastien Couillard-Després, Jürgen Meier, Jean-Pierre Julien   +2 more
doaj   +1 more source

Immunofluorescence characterization of innervation and nerve-immune cell interactions in mouse lymph nodes

European Journal of Histochemistry, 2019
The peripheral nervous system communicates specifically with the immune system via local interactions. These interactions include the “hardwiring” of sympathetic/parasympathetic (efferent) and sensory nerves (afferent) to primary (e.g., thymus and bone ...
Dailun Hu, Philip K. Nicholls, Melissa Claus, Yongkang Wu, Zhongli Shi, Wayne K. Greene, Bin Ma   +6 more
doaj   +1 more source

Molecular biomarkers in multiple sclerosis [PDF]

Arhiv za farmaciju, 2022
Multiple sclerosis (MS) is a highly heterogenous disease regarding radiological, pathological, and clinical characteristics and therapeutic response, including both the efficacy and safety profile of treatments.
Michaličková Danica, Kübra Öztürk Hatice, Das Debanjan, Osama Bukhari Syed, Slanař Ondřej   +4 more
doaj   +1 more source

Particular aspects of myelin-axon interactions in health and disease : the expression of myelin-associated glycoprotein isoforms in CNS and PNS. Early axonal pathology in the dysmyelinating peripheral neuropathy CMT1A [PDF]

, 2007
An intact myelin sheath is crucial for the rapid propagation of action potentials along myelinated axons. There are many neurodegenerative diseases associated with defect myelin sheaths resulting in severe clinical symptoms such as multiple sclerosis ...
Flück, Bettina
core   +1 more source

Serum neurofilament light in atrial fibrillation: clinical, neuroimaging and cognitive correlates [PDF]

, 2020
Emerging evidence suggests that atrial fibrillation is associated with cognitive dysfunction independently of stroke, but the underlying mechanisms remain unclear.
Coslovksy, Michael, Kuhle, Jens, for the Swiss-AF Investigators,, Fischer, Urs, Wuerfel, Jens, De Marchis, Gian Marco, Monsch, Andreas U., Lyrer, Philippe A., Schwenkglenks, Matthias, Monsch, Andreas U, Bonati, Leo H., Benkert, Pascal, Springer, Anne, Polymeris, Alexandros A., Osswald, Stefan, Beer, Jürg, Rodondi, Nicolas, Bonati, Leo H; https://orcid.org/, Conen, David, Bonati, Leo H, Sinnecker, Tim, Kobza, Richard, Lyrer, Philippe A, Polymeris, Alexandros A, Aeschbacher, Stefanie, Moschovitis, Giorgio, Kühne, Michael, Polymeris, Alexandros A; https://orcid.org/, Tim Sinnecker, Philippe A Lyrer, Jens Kuhle, Matthias Schwenkglenks, Stefan Osswald, Gian Marco De Marchis, null null, Jürg Beer, Giorgio Moschovitis, Michael Kühne, Alexandros A Polymeris, Stefanie Aeschbacher, Andreas U Monsch, Richard Kobza, Urs Fischer, Anne Springer, David Conen, Michael Coslovksy, Jens Wuerfel, Pascal Benkert, Nicolas Rodondi, Leo H Bonati   +49 more
core   +3 more sources