Results 11 to 20 of about 65,054 (212)
Paradoxical increase of neurofilaments in SMA patients treated with onasemnogene abeparvovec-xioi
Frontiers in Neurology, 2023 Background/ObjectiveNeurofilament light chain (NfL) has been proposed as a biomarker reflecting disease severity and therapy response in children with spinal muscular atrophy type 1 and 2 (SMA1 and 2). The objective of this study was to examine how serum
Marina Flotats-Bastardas +10 more
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Neurofilaments and Neurofilament Proteins in Health and Disease [PDF]
Cold Spring Harbor Perspectives in Biology, 2017 SUMMARYNeurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments (IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M [neurofilament middle]; NF-H [neurofilament heavy]; and α-internexin or peripherin), each having different domain structures and functions.
Aidong, Yuan +3 more
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Neurofilaments at a glance [PDF]
Journal of Cell Science, 2012 Neurofilaments (NFs) are intermediate filaments with a diameter of 10 nm, similar to that of neurons. Although they are present in perikarya and dendrites, neurofilaments are particularly abundant in axons, where they are essential for the radial growth of axons during development, the ...
Aidong, Yuan +3 more
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Frontiers in Neurology, 2022 IntroductionNeurofilament light (NfL) can be detected in blood of healthy individuals and at elevated levels in those with different neurological diseases.
Nicole Rübsamen +8 more
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Mechanisms of Mitochondria-Neurofilament Interactions [PDF]
, 2003 Mitochondria are localized to regions of the cell where ATP consumption is high and are dispersed according to changes in local energy needs. In addition to motion directed by molecular motors, mitochondrial distribution in neuronal cells appears to ...
T. K. McIntosh +5 more
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Breaking the amyotrophic lateral sclerosis early diagnostic barrier: the promise of general markers
Exploration of Neuroprotective Therapy, 2023 Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that is associated with selective and progressive loss of motor neurons. As a consequence, the symptoms of ALS are muscle cramps and weakness, and it eventually leads to death. The
Yizhou Lu +4 more
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Clinical Phenotyping and Biomarkers in Spinal and Bulbar Muscular Atrophy
Frontiers in Neurology, 2021 Background: Spinal and bulbar muscular atrophy (SBMA) or Kennedy disease [OMIM: 313200] is a rare X-linked neuromuscular disease. Patients commonly present with muscle cramps, tremors, leg weakness, dysarthria and dysphagia.Methods: We deeply phenotyped ...
Elina Millere +18 more
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Serum Neurofilament Levels in Children With Febrile Seizures and in Controls
Frontiers in Neuroscience, 2020 ObjectiveNeuroaxonal damage is reflected by serum neurofilament light chain (sNfL) values in a variety of acute and degenerative diseases of the brain. The aim of this study was to investigate the impact of febrile and epileptic seizures on sNfL, serum ...
Katrina S. Evers +10 more
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Generation of a Spiral Ganglion Neuron Degeneration Mouse Model
Frontiers in Cell and Developmental Biology, 2021 Spiral ganglion neurons (SGNs) can be injured by a wide variety of insults. However, there still is a lack of degeneration models to specifically damage the SGNs without disturbing other types of cells in the inner ear. This study aims to generate an SGN-
Zhengqing Hu +4 more
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The polymer brush model of neurofilament projections: Effect of protein composition [PDF]
, 2010 Applying self-consistent field theory, we consider a coarse-grained model for the polymerlike projections of neurofilament (NF) proteins that form a brush structure around neurofilaments.
Zhulina, E.B., Leermakers, F.A.M.
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