Results 31 to 40 of about 65,054 (212)

Intermediate Filaments as Organizers of Cellular Space: How They Affect Mitochondrial Structure and Function

open access: yesCells, 2016
Intermediate filaments together with actin filaments and microtubules form the cytoskeleton, which is a complex and highly dynamic 3D network. Intermediate filaments are the major mechanical stress protectors but also affect cell growth, differentiation,
Nicole Schwarz, Rudolf E. Leube
doaj   +1 more source

Age-dependent increase of cytoskeletal components in sensory axons in human skin

open access: yesFrontiers in Cell and Developmental Biology, 2022
Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites.
Klara Metzner   +17 more
doaj   +1 more source

Neurofilament redistribution in transected nerves: evidence for bidirectional transport of neurofilaments [PDF]

open access: yesThe Journal of Neuroscience, 1991
Nerve fibers of the C57BL/6/Ola mouse exhibit very slow Wallerian degeneration following axotomy, thus allowing prolonged observation of mammalian axons separated from their cell bodies. The present study utilized teased-fiber preparations, silver histochemistry, immunocytochemistry, and electron microscopy to examine the distribution of axonal ...
J D, Glass, J W, Griffin
openaire   +2 more sources

Looking for the origins of axons

open access: yeseLife, 2022
Pyramidal neurons with axons that exit from dendrites rather than the cell body itself are relatively common in non-primates, but rare in monkeys and humans.
Kathleen S Rockland
doaj   +1 more source

Neurofilament sidearms modulate parallel and crossed-filament orientations inducing nematic to isotropic and re-entrant birefringent hydrogels

open access: yes, 2013
Neurofilaments are intermediate filaments assembled from the subunits neurofilament-low, neurofilament-medium and neurofilament-high. In axons, parallel neurofilaments form a nematic liquid-crystal hydrogel with network structure arising from ...
Bausch, A.   +4 more
core   +1 more source

Fast Transport of Neurofilament Protein along Microtubules in Squid Axoplasm [PDF]

open access: yes, 2000
Using squid axoplasm as a model system, we have visualized the fast transport of non-filamentous neurofilament protein particles along axonal microtubules.
Helfand, Brian T.   +7 more
core   +1 more source

Biomarkers and the Development of a Personalized Medicine Approach in Spinal Muscular Atrophy

open access: yesFrontiers in Neurology, 2019
Recent unprecedented advances in treatment for spinal muscular atrophy (SMA) enabled patients to access the first approved disease modifying therapy for the condition.
Didu S. T. Kariyawasam   +6 more
doaj   +1 more source

Deciphering Multiple Sclerosis Progression

open access: yesFrontiers in Neurology, 2021
Multiple sclerosis (MS) is primarily an inflammatory and degenerative disease of the central nervous system, triggered by unknown environmental factors in patients with predisposing genetic risk profiles.
Virginia Meca-Lallana   +11 more
doaj   +1 more source

Comparison of neurofilament light and heavy chain in spinal muscular atrophy and amyotrophic lateral sclerosis: A pilot study

open access: yesBrain and Behavior, 2023
Background Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) were two major motor neuron diseases with similar symptoms and poor outcomes.
Jin‐Yue Li   +7 more
doaj   +1 more source

CNS embryonal tumor with PLAGL amplification #6 Neurofilament immunostain

open access: yes, 2022
Neurofilament immunostained section from CNS embryonal tumor with PLAGL amplification #6.  Patient A388, PLAGL1 amplified.
David Solomon (4497931)
core   +1 more source

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