Results 61 to 70 of about 65,054 (212)

Specific detection of neuronal cell bodies: in situ hybridization with a biotin-labeled neurofilament cDNA probe.

, 1986
We have used a biotinylated, 300-nucleotide cDNA probe which encodes the 68,000 MW neurofilament protein to detect neurofilament-specific mRNA in situ.
F Grosveld, P Liesi, L Rechardt, P Vilja, J P Julien   +4 more
core   +1 more source

Absence of the Mid-sized Neurofilament Subunit Decreases Axonal Calibers, Levels of Light Neurofilament (NF-L), and Neurofilament Content [PDF]

The Journal of Cell Biology, 1998
Neurofilaments (NFs) are prominent components of large myelinated axons and probably the most abundant of neuronal intermediate filament proteins. Here we show that mice with a null mutation in the mid-sized NF (NF-M) subunit have dramatically decreased levels of light NF (NF-L) and increased levels of heavy NF (NF-H).
G A, Elder, V L, Friedrich, P, Bosco, C, Kang, A, Gourov, P H, Tu, V M, Lee, R A, Lazzarini   +7 more
openaire   +2 more sources

A Mechanism for Neurofilament Transport Acceleration through Nodes of Ranvier

, 2020
© 2020 Ciocanel et al. Neurofilaments are abundant space-filling cytoskeletal polymers in axons that are transported along microtubule tracks. Neurofilament transport is accelerated at nodes of Ranvier, where axons are locally constricted.
Jung, Peter, Ciocanel, Maria Veronica, Brown, Anthony   +2 more
core   +1 more source

A motor for neurofilaments [PDF]

The Journal of Cell Biology, 2002
![Graphic][1] Myosin Va (gold particles) binds neurofilaments. Neurofilaments modulate the shape and size of neurons. On [page 279][2], Rao et al. describe several lines of evidence demonstrating that neurofilaments interact with the motor protein myosin Va, and that ...
openaire   +1 more source

Association between detection of phosphorylated neurofilament heavy subunit and candidate biomarker levels.

, 2021
Association between detection of phosphorylated neurofilament heavy subunit and candidate biomarker levels.
Nobutake Shimojo (4955965), Kanji Uchida (3756475), Toru Ogata (281778), Maiko Hasegawa-Moriyama (5076809), Masahiko Sumitani (464746), Reo Inoue (7450316), Kazuhito Mietani (7450313), Makoto Kurano (514014)   +7 more
core   +1 more source

Phosphorylated neurofilament heavy chain (pNfH) concentration in cerebrospinal fluid predicts overall disease aggressiveness (D50) in amyotrophic lateral sclerosis

Frontiers in Neuroscience
IntroductionAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, characterized by tremendous clinical heterogeneity that necessitates reliable biomarkers for the trajectory of the disease.
Julia Meyer, Nayana Gaur, Janina von der Gablentz, Bernd Friedrich, Annekathrin Roediger, Annekathrin Roediger, Julian Grosskreutz, Julian Grosskreutz, Julian Grosskreutz, Robert Steinbach   +9 more
doaj   +1 more source

Expression of neural cell adhesion molecules and neurofilament protein isoforms in skeletal muscle tumors [PDF]

, 1998
In a series of rhabdomyosarcomas, the expression of neural cell adhesion molecules (NCAM) and neurofilament isoforms was probed in frozen sections.
Muntinghe, F L, Molenaar, W M
core   +1 more source

Neurofilament light chain kinetics as a biomarker for polyneuropathy in V122I hereditary transthyretin amyloidosis

, 2023
Neurofilament light chain kinetics as a biomarker for polyneuropathy in V122I hereditary transthyretin ...
Luke Zheng (17613718), Gheorghe Doros (4480093), John Berk (3454022), Michelle C. Kaku (17613721), Vaishali Sanchorawala (3139491), Brian Spencer (222903), K. H. Vincent Lau (9410153), Tatiana Prokaeva (3139497)   +7 more
core   +1 more source

Specific detection of neuronal cell bodies: in situ hybridization with a biotin-labelled neurofilament cDNA probe.

, 1986
We have used a biotinylated, 300-nucleotide cDNA probe which encodes the 68,000 MW neurofilament protein to detect neurofilament-specific mRNA in situ. The neurofilament message specifically demonstrates the neuronal cell bodies, in contrast to the usual
Vilja, P., Rechardt, L., Julien, J-P. (Jean-Pierre), Liesi, P., Grosveld, F.G. (Frank)   +4 more
core   +1 more source

Cerebrospinal fluid neurofilament light chain levels in children with acquired demyelinating syndrome

Frontiers in Pediatrics
ObjectiveTo study the cerebrospinal fluid (CSF) neurofilament light chain (NfL) in pediatric acquired demyelinating syndrome (ADS) and its association with factors of laboratory and imaging results.MethodsWe analyzed clinical data from children with ADS ...
Wenlin Wu, Chi Hou, Wenxiao Wu, Huiling Shen, Yiru Zeng, Lianfeng Chen, Yinting Liao, Haixia Zhu, Yang Tian, Bingwei Peng, Wen-Xiong Chen, Xiaojing Li   +11 more
doaj   +1 more source