Results 131 to 140 of about 28,521 (342)

Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study

Annals of Neurology, EarlyView.
Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai, Joanne Wuu, Magdalena Koziczak‐Holbro, Andrea Malaspina, Volkan Granit, Jessica P. Hernandez, Anne Cooley, Ruchika Sachdev, Lili Yu, Michael Bidinosti, Ludivine Flotte, Mark Nash, Lori L. Jennings, James D. Berry, Lucie I. Bruijn, Sophie Brachat, Michael Benatar   +16 more
wiley   +1 more source

Chronic hepatitis E virus-induced spinal cord atrophy in a patient with chronic lymphatic leukemia: a case report and interdisciplinary management proposal

Frontiers in Immunology
BackgroundThe hepatitis E virus (HEV) can cause acute viral hepatitis with or without neurological manifestations, and occasionally progresses to chronic infection in immunocompromised individuals.
Marvin Ritter, Olaposi Yomade, Olaposi Yomade, Ben-Ole Holtz, Stefanie Deinhardt-Emmer, Aaron Lawson McLean, Aaron Lawson McLean, Stefanie Hartinger, Stefanie Hartinger, Julia Bechwar, Matthias Schwab, André Huss, Christian Mawrin, Christian Mawrin, Hubertus Axer, Karin G. Schrenk, Karin G. Schrenk, Philipp A. Reuken, Irina Mäurer, Irina Mäurer   +19 more
doaj   +1 more source

Adaptive pattern recognition by mini-max neural networks as a part of an intelligent processor [PDF]

In this decade and progressing into 21st Century, NASA will have missions including Space Station and the Earth related Planet Sciences. To support these missions, a high degree of sophistication in machine automation and an increasing amount of data ...
Szu, Harold H.
core   +1 more source

P4‐324: Plasma Neurofilament Light Concentration Predicts Long‐Term Outcome an Acute Stroke [PDF]

, 2016
Sebastiaan Engelborghs, Erik Fransén, Ann De Vos, Eugeen Vanmechelen, Naomi De Roeck, Maria Bjerke, Niklas Norgren, Kaj Blennow, Henrik Zetterberg, Raf Brouns   +9 more
openalex   +1 more source

From Diagnosis to Disease Staging: Multisite Validation of Cerebrospinal Fluid Molecular Tests in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective The growing demand for personalized treatment in multiple sclerosis (MS) highlights the need for more precise biomarkers that can outperform magnetic resonance imaging and clinical assessment in patient stratification. Advances in multiplex proteomic technologies suggest that cerebrospinal fluid (CSF) analysis at MS onset may not only improve
Laura Ghezzi, Peter Kosa, Mark Greenwood, Enrique Alvarez, C.L. Freedman, Anne H. Cross, Francesca Pace, Mark S. Freedman, Joanna Kocot, Laura Piccio, Bibiana Bielekova   +10 more
wiley   +1 more source

Cerebrospinal Fluid Neurofilaments Light-Chain Differentiate Patients Affected by Alzheimer’s Disease with Different Rate of Progression (RoP): A Preliminary Study

Brain Sciences
Alzheimer’s disease (AD) is the most common neurodegenerative disorder and a leading cause of dementia. One major challenge for clinicians is accurately assessing the rate of disease progression (RoP) early in the diagnostic process, which is crucial for
Valeria Blandino, Tiziana Colletti, Paolo Ribisi, Domenico Tarantino, Viviana Mosca, Luisa Agnello, Marcello Ciaccio, Tommaso Piccoli   +7 more
doaj   +1 more source

Formation of Compact Myelin Is Required for Maturation of the Axonal Cytoskeleton [PDF]

, 1999
Although traditional roles ascribed to myelinating glial cells are structural and supportive, the importance of compact myelin for proper functioning of the nervous system can be inferred from mutations in myelin proteins and neuropathologies associated ...
Brady, Scott T., de Waegh, Sylvie M., Kirkpatrick, Laura L., Lee, Virginia M.-Y., Readhead, Carol, Tu, Pang-Hsien, Witt, Andrea S.   +6 more
core  

Combination of Serum Neurofilament Light Chain and Serum Cardiac Troponin T as Biomarkers Improves Diagnostic Accuracy in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective We aimed to evaluate the clinical utility of serum neurofilament light chain (sNfL) and cardiac troponin T (cTnT) in amyotrophic lateral sclerosis (ALS) and assess whether their combination improves diagnostic accuracy. Methods We retrospectively analyzed 293 ALS patients, 85 neurodegenerative disease controls, and 29 healthy controls.
Paula Lindenborn, Rachel Fabian, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Sarah Bernsen, Patrick Weydt   +6 more
wiley   +1 more source

Plasma glial fibrillary acidic protein, neurofilament light, phosphorylated‐tau‐181 and amyloid β_42/40 as prognostic biomarkers for clinical progression to dementia in individuals with subjective cognitive decline and mild cognitive impairment [PDF]

, 2022
Madison I. J. Honey, Inge M.W. Verberk, Mariam Gouda, Zulaiga Hussainali, Lior A. Kroeze, Mardou van Leeuwenstijn, Arenda Mank, Calvin Trieu, David H. Wilson, Yolande A.L. Pijnenburg, Wiesje M. van der Flier, Argonde C. van Harten, Charlotte E. Teunissen   +12 more
openalex   +1 more source

The Epidemiology of Primary Lateral Sclerosis: Results from a Population‐Based Cohort

Annals of Neurology, EarlyView.
Objective In this population‐based study, we described the epidemiology of primary lateral sclerosis (PLS) in northern Italy and compared the clinical characteristics of patients with PLS to those with predominant upper motor neuron (PUMN) involvement and classic amyotrophic lateral sclerosis (ALS).
Rosario Vasta, Enrico Matteoni, Giorgio Pellegrino, Antonio Canosa, Umberto Manera, Francesca Palumbo, Maurizio Grassano, Sara Cabras, Alessandra Maccabeo, Fabrizio D'Ovidio, Gabriele Mora, Salvatore Gallone, Elisa D'Angelo, Letizia Mazzini, Fabiola De Marchi, Cristina Moglia, Adriano Chiò, Andrea Calvo   +17 more
wiley   +1 more source