A Single Dose of Atorvastatin Applied Acutely after Spinal Cord Injury Suppresses Inflammation, Apoptosis, and Promotes Axon Outgrowth, Which Might Be Essential for Favorable Functional Outcome. [PDF]
, 2018 The aim of our study was to limit the inflammatory response after a spinal cord injury (SCI) using Atorvastatin (ATR), a potent inhibitor of cholesterol biosynthesis.
Bacova, Maria +11 more
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Role of circulating biomarkers in spinal muscular atrophy: insights from a new treatment era
Frontiers in Neurology, 2023 Spinal muscular atrophy (SMA) is a lower motor neuron disease due to biallelic mutations in the SMN1 gene on chromosome 5. It is characterized by progressive muscle weakness of limbs, bulbar and respiratory muscles.
Querin Giorgia +6 more
doaj +1 more source
How the projection domains of NF-L and alpha-internexin determine the conformations of NF-M and NF-H in neurofilaments [PDF]
, 2010 Making use of a numerical self-consistent field method and polymer brush concepts, we model the solvated corona of neurofilaments (NF) composed of projection domains (unstructured tails) of constituent proteins.
Leermakers, F.A.M., Zhulina, E.B.
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Neurofilaments at a glance [PDF]
Journal of Cell Science, 2012 Neurofilaments (NFs) are intermediate filaments with a diameter of 10 nm, similar to that of neurons. Although they are present in perikarya and dendrites, neurofilaments are particularly abundant in axons, where they are essential for the radial growth of axons during development, the ...
Aidong, Yuan +3 more
openaire +2 more sources
Kynurenines and Neurofilament Light Chain in Multiple Sclerosis
Frontiers in Neuroscience, 2021 Multiple sclerosis is an autoimmune, demyelinating, and neurodegenerative disease of the central nervous system. In recent years, it has been proven that the kynurenine system plays a significant role in the development of several nervous system ...
Dániel Pukoli +5 more
doaj +1 more source
Inhibition of neurite outgrowth in differentiating mouse N2a neuroblastoma cells by phenyl saligenin phosphate: Effects on MAP kinase (ERK 1/2) activation, neurofilament heavy chain phosphorylation and neuropathy target esterase activity [PDF]
, 2006 Sub-lethal concentrations of the organophosphate phenyl saligenin phosphate (PSP) inhibited the outgrowth of axon-like processes in differentiating mouse N2a neuroblastoma cells (IC50 2.5 μM).
Abou-Donia +56 more
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Biomedical Papers, 2019 Background: Delirium following cardiac surgery is a relevant complication in the majority of elderly patients but its prediction is challenging. Cardiopulmonary bypass, essential for many interventions in cardiac surgery, is responsible for a severe ...
Thomas Saller +11 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2018 As part of the neuronal cytoskeleton, neurofilaments are involved in maintaining cellular integrity. In the setting of ischemic stroke, the affection of the neurofilament network is considered to mediate the transition towards long-lasting tissue damage.
Bianca Mages +16 more
doaj +1 more source
Defective axonal transport in motor neuron disease [PDF]
, 2007 Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas +77 more
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Frontiers in Neuroscience, 2021 Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disorder. As previous therapeutic trials in ALS have been severely hampered by patients’ heterogeneity, the identification of biomarkers that reliably reflect disease ...
Marie Dreger +8 more
doaj +1 more source