Results 311 to 320 of about 28,521 (342)
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Overexpression of neurofilament subunit M accelerates axonal transport of neurofilaments
Brain Research, 2000Neurofilaments are composed of three polypeptide subunits (NF-H, NF-M and NF-L). They are the most abundant cytoskeletal element in large myelinated axons and play a central role in development of axonal caliber. To perform this role, neurofilaments are transported from their site of synthesis, the cell bodies, to the distal axons.
Z, Xu, V W, Tung
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NEUROFILAMENT ANTIGENS IN ACRYLAMIDE NEUROPATHY.
Journal of Neuropathology and Experimental Neurology, 1987After repeated exposure, acrylamide (AC) produces degeneration of distal axons. Because neurons whose axons have been injured (e.g. by axotomy) show alterations in their structural and chemical properties, the present study was designed to differentiate the direct effects of AC intoxication from neuronal responses secondary to axonal injury caused by ...
B G, Gold +6 more
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Journal of Molecular Biology, 2009
Neurofilaments (NFs) are essential cytoskeletal filaments that impart mechanical integrity to nerve cells. They are assembled from three distinct molecular mass proteins that bind to each other to form a 10-nm-diameter filamentous rod with sidearm extensions.
Rakwoo, Chang +2 more
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Neurofilaments (NFs) are essential cytoskeletal filaments that impart mechanical integrity to nerve cells. They are assembled from three distinct molecular mass proteins that bind to each other to form a 10-nm-diameter filamentous rod with sidearm extensions.
Rakwoo, Chang +2 more
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Expanded Polyglutamine Domain Proteins Bind Neurofilament and Alter the Neurofilament Network
Experimental Neurology, 1999Eight inherited neurodegenerative diseases are caused by genes with expanded CAG repeats coding for polyglutamine domains in the disease-producing proteins. The mechanism by which this expanded polyglutamine domain causes neurodegenerative disease is unknown, but nuclear and cytoplasmic polyglutamine protein aggregation is a common feature.
Y, Nagai +4 more
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Annals of the New York Academy of Sciences, 2009
Immune responses to neuronal proteins are a frequent occurrence in neurodegenerative diseases. This study determines the occurrence of autoantibodies to the three neurofilament subunits in phosphorylated and dephosphorylated forms and relates these measures to age, human leukocyte antigen (HLA), and severity of disease in Down syndrome (DS).
Ija Talja +7 more
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Immune responses to neuronal proteins are a frequent occurrence in neurodegenerative diseases. This study determines the occurrence of autoantibodies to the three neurofilament subunits in phosphorylated and dephosphorylated forms and relates these measures to age, human leukocyte antigen (HLA), and severity of disease in Down syndrome (DS).
Ija Talja +7 more
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Neurofilaments in diabetic neuropathy
2002This review discusses the role of abnormal neurofilament (NF) expression, processing, and structure as an etiological factor in diabetic neuropathy. Diabetic sensory and autonomic neuropathy in humans is associated with a spectrum of structural changes in peripheral nerve that includes axonal degeneration, paranodal demyelination, and loss of ...
Paul, Fernyhough, Robert E, Schmidt
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Phosphorylation of neurofilament H subunit as related to arrangement of neurofilaments
Journal of Neuroscience Research, 1994AbstractTo find out what causes differences in phosphorylation states in neurofilaments (NF), we selected two types of dendrite, one provided with very few NFs (Purkinje cell) and the other with relatively many (anterior horn cell). We examined these with four monoclonal antibodies selected by the Western blot analysis, two (NE14 and SMI31 ...
T, Gotow, J, Tanaka
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Neurofilaments and glial filaments
Tissue and Cell, 1970The structure of neurofilaments and glial filaments are compared. Both filaments are composed of three subunits-a globule, interconnecting crossbar and side-arms. These elements form a tubular arrangement and their dimensions are given. Since the subunits of both filaments have a similar arrangement but differ in size, it is concluded that they ...
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Phosphorylation protects neurofilaments against proteolysis
Journal of Neuroimmunology, 1987During incubation with phosphatase, the 200 kDa neurofilament protein in cytoskeletal preparations is degraded extensively. Degradation, which is divalent cation-independent, does not occur when inhibitors of phosphatase are added. The 160 kDa chymotryptic fragment of neurofilaments or affinity-purified 200 kDa protein are not degraded by phosphatase ...
M E, Goldstein +2 more
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Neurofilaments in neurologic disease
Neurofilaments (NFs), major cytoskeletal constituents of neurons, have emerged as universal biomarkers of neuronal injury. Neuroaxonal damage underlies permanent disability in various neurological conditions. It is crucial to accurately quantify and longitudinally monitor this damage to evaluate disease progression, evaluate treatment effectiveness ...Christina, Mousele +2 more
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