Results 31 to 40 of about 28,521 (342)

Serum and CSF Biomarkers Predict Active Early Cognitive Decline Rather Than Established Cognitive Impairment at the Moment of RRMS Diagnosis

Diagnostics, 2022
(1) Background: Cognitive impairment (CI) begins early in the evolution of multiple sclerosis (MS) but may only become obvious in the later stages of the disease.
Vlad Eugen Tiu, Bogdan Ovidiu Popescu, Iulian Ion Enache, Cristina Tiu, Elena Terecoasa, Cristina Aura Panea   +5 more
doaj   +1 more source

Copurification of actin and desmin from chicken smooth muscle and their copolymerization in vitro to intermediate filaments [PDF]

, 1979
Desmin is a 50,000-mol wt protein that is enriched along with 100-A filaments in chicken gizzard that has been extracted with 1 M KI. Although 1 M KI removes most of the actin from gizzard, a small fraction of this protein remains persistently insoluble,
Hubbard, Bruce D., Lazarides, Elias
core   +3 more sources

Molecular markers of disease severity and response to nusinersen therapy in 5q spinal muscular atrophy (literature review)

Нервно-мышечные болезни, 2023
Currently, there are three drugs in the world for the pathogenetic therapy of spinal muscular atrophy 5q: nusinersen, risdiplam and onasemnogene abeparvovek.
K. D. Popov, T. M. Alekseeva, V. D. Nazarov, A. I. Vlasenko, S. M. Malyshev   +4 more
doaj   +1 more source

Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination [PDF]

, 2017
Remyelination is in the center of new therapies for the treatment of multiple sclerosis to resolve and improve disease symptoms and protect axons from further damage.
Bramlett, Brück, Brück, Clark, Cunningham, Foote, Fünfschilling, Gudi, Hiremath, Hiremath, Irvine, Irvine, Kornek, Kuhlmann, Kutzelnigg, Lassmann, Lassmann, Lee, Lindner, Lindner, Lucchinetti, Manrique-Hoyos, Mason, Matsushima, McKenzie, Mildner, Morrison, Murray, Nikic, Otsuka, Patrikios, Pierce, Schuh, Simons, Singh, Skripuletz, Sorbara, Stidworthy, Trapp   +38 more
core   +1 more source

Neurofilaments as Emerging Biomarkers of Neuroaxonal Damage to Differentiate Behavioral Frontotemporal Dementia from Primary Psychiatric Disorders: A Systematic Review

Diagnostics, 2021
The behavioral variant of frontotemporal dementia (bvFTD) is a clinical syndrome resulting from various causes of neuronal demises associated with frontotemporal lobar degeneration.
Vincent Davy, Julien Dumurgier, Aurore Fayosse, Claire Paquet, Emmanuel Cognat   +4 more
doaj   +1 more source

Nonlinear Elasticity in Biological Gels [PDF]

, 2004
Unlike most synthetic materials, biological materials often stiffen as they are deformed. This nonlinear elastic response, critical for the physiological function of some tissues, has been documented since at least the 19th century, but the molecular ...
AD Karakaplan, AY Grosberg, Cornelis Storm, D Morse, DA Head, F Gittes, F Gittes, F MacKintosh, F. C. MacKintosh, J Marko, J Wilhelm, J Wilhelm, J Xu, Jennifer J. Pastore, JF Leterrier, JO Hjortdal, JV Shah, K Kroy, L Ma, LD Landau, LD Landau, LRG Treloar, LZ Wang, M Fixman, ML Gardel, PA Janmey, PA Janmey, PA Janmey, PA Janmey, Paul A. Janmey, RE Shadwick, SB Smith, T. C. Lubensky, Y Fung   +33 more
core   +2 more sources

Shedding light on neurofilament involvement in cognitive decline in obstructive sleep apnea and its possible role as a biomarker

Frontiers in Psychiatry, 2023
Obstructive sleep apnea is one of the most common sleep disorders with a high estimated global prevalence and a large number of associated comorbidities in general as well as specific neuropsychiatric complications such as cognitive impairment.
Julia Jaromirska, Piotr Kaczmarski, Dominik Strzelecki, Marcin Sochal, Piotr Białasiewicz, Agata Gabryelska   +5 more
doaj   +1 more source

Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects [PDF]

, 2009
Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17
Falzone, Tomas Luis, Goldstein, Lawrence S. B., Lillo, Concepción, Rodrigues, Elizabeth M., Stokin, Gorazd B., Westerman, Eileen L., Williams, David S.   +6 more
core   +1 more source

Sensory-motor deficits and neurofilament disorganization in gigaxonin-null mice

Molecular Neurodegeneration, 2011
Background Giant Axonal Neuropathy (GAN) is a fatal neurodegenerative disorder with early onset characterized by a severe deterioration of the peripheral and central nervous system, involving both the motor and the sensory tracts and leading to ataxia ...
Boizot Alexia, Ganay Thibault, Burrer Renaud, Chauvin Jean, Bomont Pascale   +4 more
doaj   +1 more source

Neurofilaments and tau proteins in cerebrospinal fluid and serum in dementias and neuroinflammation

Biomedical Papers, 2017
Aims: The aim of this study was to evaluate the diagnostic potential of cerebrospinal fluid (CSF) and serum levels of neurocytoskeletal proteins and their ratios for the diagnosis of dementias and to assess the differences in neurocytoskeletal proteins ...
Lenka Fialova, Ales Bartos, Jana Svarcova   +2 more
doaj   +1 more source