Results 41 to 50 of about 28,521 (342)
Biomedicines, 2023 (1) Background: Early disability accrual in RRMS patients is frequent and is associated with worse long-term prognosis. Correctly identifying the patients that present a high risk of early disability progression is of utmost importance, and may be aided ...
Vlad Eugen Tiu +5 more
doaj +1 more source
Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments [PDF]
The Journal of Cell Biology, 2003 Neurofilaments possess side arms that comprise the carboxy-terminal domains of neurofilament middle and heavy chains (NFM and NFH); that of NFH is heavily phosphorylated in axons. Here, we demonstrate that phosphorylation of NFH side arms is a mechanism for regulating transport of neurofilaments through axons. Mutants in which known NFH phosphorylation
Ackerley, S +7 more
openaire +3 more sources
Blood Based Biomarkers of Central Nervous System Involvement in Wilson’s Disease
Diagnostics, 2023 Wilson’s disease (WD) is an inherited disorder of copper metabolism with clinical symptoms related to pathological copper accumulation, which are mainly hepatic and/or neuropsychiatric.
Agnieszka Antos +5 more
doaj +1 more source
Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease [PDF]
, 2019 Alzheimer’s disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Burris, Thomas P +9 more
core +3 more sources
Frontiers in Aging Neuroscience, 2015 In the present study, an unbiased stereological method was used to determine the number of all neurons in Nissl stained sections of the inferior colliculus (IC), medial geniculate body (MGB) and auditory cortex (AC) in rats (strains Long Evans and ...
Jana eBurianová +2 more
doaj +1 more source
Mechanisms for the maintenance and eventual degradation of neurofilament proteins in the distal segments of severed goldfish Mauthner axons [PDF]
, 1996 Cellular mechanisms that might affect the degradation of neurofilament proteins (NFPs) were examined in the distal segments of severed goldfish Mauthner axons (M-axons), which do not degenerate for more than 2 months after severance.
Archer, Cullen +3 more
core +1 more source
CSF Biomarkers in COVID-19 Associated Encephalopathy and Encephalitis Predict Long-Term Outcome
Frontiers in Immunology, 2022 Patients with coronavirus disease 2019 (COVID-19) frequently develop acute encephalopathy and encephalitis, but whether these complications are the result from viral-induced cytokine storm syndrome or anti-neural autoimmunity is still unclear.
Mar Guasp +19 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu +9 more
wiley +1 more source
Expression of Neurofilament Subunits at Neocortical Glutamatergic and GABAergic Synapses
Frontiers in Neuroanatomy, 2018 Neurofilaments (NFs) are neuron-specific heteropolymers that have long been considered as structural proteins. However, it has recently been documented that they may play a functional role at synapses.
Luca Bragina +3 more
doaj +1 more source
Frontiers in Neurology, 2021 Conversion to secondary progressive (SP) course is the decisive factor for long-term prognosis in relapsing multiple sclerosis (MS), generally considered the clinical equivalent of progressive MS-associated neuroaxonal degeneration.
Nik Krajnc +3 more
doaj +1 more source