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Refractory Neurogenic Detrusor Overactivity

International Journal of Clinical Practice, 2006
F. CRUZ, C. SILVA
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Intravesical resiniferatoxin for patients with neurogenic detrusor overactivity

International Journal of Urology, 2004
AbstractBackground: Resiniferatoxin (RTX), a substance isolated from some species of Euphobia, is a specific C‐fiber neurotoxin which produces desensitization rather than excitation. At first, we performed intravesical RTX therapy on eight patients with neurogenic detrusor overactivity.
Toyohiko, Watanabe, Teruhiko, Yokoyama, Katsumi, Sasaki, Kunihiro, Nozaki, Hideo, Ozawa, Hiromi, Kumon   +5 more
openaire   +2 more sources

Botulinum Toxin Therapy for Neurogenic Detrusor Overactivity

Urologic Clinics of North America, 2010
Detrusor injection of botulinum toxin (BTX) has shown great promise in the treatment of neurogenic detrusor overactivity (NDO) refractory to conservative therapy. Despite a paucity of prospective evidence, there exists a growing consensus that BTX injection therapy is a well-tolerated, low-risk therapy.
Marc C, Smaldone, Benjamin T, Ristau, Wendy W, Leng   +2 more
openaire   +2 more sources

Management of neurogenic detrusor overactivity.

The Canadian journal of urology, 2021
INTRODUCTION Neurogenic lower urinary tract dysfunction (NLUTD) refers to altered function of the urinary bladder, bladder outlet, and external urinary sphincter related to a confirmed neurologic disorder. Neurogenic detrusor overactivity (NDO) is a subset of NLUTD that frequently results in incontinence and may be associated with elevated bladder ...
Cassra B, Clark, Radhika, Ragam, Akhil K, Das, Patrick J, Shenot   +3 more
openaire   +1 more source

Аbobotulinum toxin A (Dysport®) for the treatment of neurogenic detrusor overactivity

Urologiia, 2023
Increasing of treatment efficiency in patients with neurogenic detrusor overactivity is an important medical and social problem. Its significance is determined not only by the high prevalence of neurogenic lower urinary tract dysfunctions, but also by the high risk of complications, among which an impaired renal function takes the leading place ...
G G, Krivoborodov, I V, Kuzmin, V V, Romikh   +2 more
openaire   +2 more sources

Botulinum a Toxin Injections Into the Detrusor: An Effective Treatment in Idiopathic and Neurogenic Detrusor Overactivity?

Neurourology and Urodynamics, 2005
AbstractAimsTo assess and compare the effect of botulinum A toxin (BTX‐A) injections into the detrusor in idiopathic and neurogenic detrusor overactivity resistant to anticholinergic treatment.Patients and MethodsIn a prospective study, 11 patients with idiopathic and 11 with neurogenic detrusor overactivity resistant to anticholinergic treatment were ...
Thomas M Kessler, Urs E Studer, Fiona C Burkhard   +2 more
exaly   +4 more sources

OnabotulinumtoxinA in Refractory Neurogenic Detrusor Overactivity

European Urology, 2011
OnabotulinumtoxinA (Botox; Allergan, Inc., Irvine, CA, USA) is expected to be licensed for treatment of neurogenic detrusor overactivity (NDO) soon. This is the culmination of a long journey that has taken >10 yr. Researchers worldwide, both basic science and clinical, and many thousands who have received the treatment on a ‘‘named patient basis’’ are ...
openaire   +3 more sources

New treatments for neurogenic detrusor overactivity

Clinical Investigation, 2015
Patients with neurogenic detrusor overactivity (NDO) are a heterogeneous group with different underlying neurologic conditions associated with several urinary symptoms and systemic complications. The first-line, mainstay treatment of NDO are antimuscarinic drugs, but unfortunately they show a low adherence over the years.
Gabriele Gaziev, Valerio Iacovelli, Luca Topazio, Daniele Bianchi, Enrico Finazzi Agrò   +4 more
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An evaluation of onobotulinumtoxinA as a therapeutic option for pediatric neurogenic detrusor overactivity

Expert Review of Neurotherapeutics, 2023
Neurogenic detrusor overactivity (NDO) results in involuntary detrusor contractions during bladder filling or storage risking transmission of pressure to the upper urinary tracts and/or significant incontinence. The goals of bladder management in children with NDO prioritize the preservation of renal function, prevention of UTIs, and optimizing quality
Leslie M, Peard, John C, Pope, Roger, Dmochowski   +2 more
openaire   +2 more sources

Increased Expression of Connexin 43 in the Overactive Neurogenic Detrusor

European Urology, 2004
The cellular mechanisms involved in unstable uncontrolled detrusor contractions in the human bladder remain unknown. One hypothesis, based on electron microscopical observations and animal studies, is that gap junctions are present in the human detrusor and are increased in patients with detrusor overactivity.
A, Haferkamp, J, Mundhenk, P J, Bastian, A, Reitz, J, Dörsam, J, Pannek, S, Schumacher, B, Schurch, R, Büttner, S C, Müller   +9 more
openaire   +2 more sources