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Neuropharmacologic Distinction of Neurogenic Orthostatic Hypotension Syndromes
Clinical Neuropharmacology, 2006Neurogenic orthostatic hypotension (OH) characterizes pure autonomic failure (PAF), multiple system atrophy (MSA), and Parkinson disease (PD) with autonomic failure. We used neuropharmacologic probes that might distinguish these diseases based on loss of sympathetic noradrenergic nerves in PAF and PD + OH but not in MSA, and related the results to ...
Yehonatan, Sharabi +6 more
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Archives of Internal Medicine, 1984
The maintenance of adequate upright BP requires both a baroreceptor-mediated feedback loop and an effective circulating blood volume. Although functional disruptions of these mechanisms are reversible and common, several permanent and often progressive neurologic disorders exist that interfere with necessary reflexes and orthostatic BP control ...
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The maintenance of adequate upright BP requires both a baroreceptor-mediated feedback loop and an effective circulating blood volume. Although functional disruptions of these mechanisms are reversible and common, several permanent and often progressive neurologic disorders exist that interfere with necessary reflexes and orthostatic BP control ...
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Droxidopa for neurogenic orthostatic hypotension
Expert Opinion on Orphan Drugs, 2015Introduction: Neurogenic orthostatic hypotension is a disabling manifestation of autonomic failure seen in disorders such as multiple system atrophy, pure autonomic failure, Lewy body disease, Parkinson’s disease, autonomic neuropathies and dopamine β-hydroxylase deficiency.Areas covered: Droxidopa is an orally administered norepinephrine prodrug that ...
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[Medication for Neurogenic Orthostatic Hypotension].
Brain and nerve = Shinkei kenkyu no shinpo, 2023Orthostatic hypotension is a phenomenon characterized by reduction in blood pressure secondary to the inability to adapt to changes in blood volume distribution (pooling of blood in the lower extremities) observed when standing from a seated or supine position. Orthostatic hypotension is classified into neurogenic and non-neurogenic types.
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Management of Supine Hypertension Complicating Neurogenic Orthostatic Hypotension
CNS Drugs, 2017Neurogenic orthostatic hypotension (NOH) can be present in a number of disorders, including synucleinopathies, autoimmune disorders, and various genetic disorders. All are characterized by defective norepinephrine release from sympathetic terminals upon standing, resulting in impaired vasoconstriction.
Jacquie, Baker, Kurt, Kimpinski
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Droxidopa approved for neurogenic orthostatic hypotension
American Journal of Health-System Pharmacy, 2014Droxidopa, a synthetic amino acid precursor of norepinephrine, has been approved as oral therapy for the treatment of neurogenic orthostatic hypotension, FDA and Chelsea Therapeutics announced on February 18.
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The arterial baroreflex in neurogenic orthostatic hypotension
Clinical Autonomic Research, 2023Phillip, Low, Wolfgang, Singer
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All orthostatic hypotension is neurogenic
Clinical Autonomic Research, 2023openaire +2 more sources
Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
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Efficacy of Midodrine for Neurogenic Orthostatic Hypotension
JAMA: The Journal of the American Medical Association, 1997To the Editor. —Orthostatic hypotension due to autonomic failure is an incapacitating condition for which treatment, despite various drug interventions (eg, yohimbine, metoclopramide, β-blockers, somatostatin analog) is not yet resolved. Therefore, the encouraging results of the study of Dr Low and colleagues 1 are potentially of great importance ...
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