Results 1 to 10 of about 1,420 (176)

Droxidopa in Critical Care: A Systematic Review of an Emerging Off-Label Practice [PDF]

Critical Care Research and Practice
Background Prolonged use of intravenous (IV) vasopressors in critically ill patients is associated with significant complications. Droxidopa, a norepinephrine precursor approved for neurogenic orthostatic hypotension, has gained interest as an off‐label agent for facilitating vasopressor weaning in ICU settings. This systematic review aimed to evaluate
Carlos Valladares, Franklyn Vega Batista, Marc Faltas, Mareya Menteyas, Katherine Chiapaikeo-Poco   +4 more
doaj   +3 more sources

Droxidopa for Management of Chronic Hypotension in Hemodialysis [PDF]

Kidney International Reports
Anuradha Jayanti, Mohamed Elewa
doaj   +4 more sources

Impact of COVID‑19 infection on subsequent prescriptions of autonomic dysfunction pharmacotherapy: a nationwide propensity‑score‑matched Cohort study in Japan [PDF]

Annals of Medicine
Background Autonomic dysfunction, including orthostatic hypotension and postural tachycardia syndrome, has emerged as a COVID-19 complication.
Daisuke Miyamori, Masanori Ito
doaj   +2 more sources

Computational analysis of RNA methyltransferase Rv3366 as a potential drug target for combating drug-resistant Mycobacterium tuberculosis [PDF]

Frontiers in Molecular Biosciences, 2023
Mycobacterium tuberculosis (M.tb) remains a formidable global health threat. The increasing drug resistance among M.tb clinical isolates is exacerbating the current tuberculosis (TB) burden.
Tasmin Nazim, Vipul Kumar, Faraz Ahmed, Nasreen Z. Ehtesham, Seyed E. Hasnain, Seyed E. Hasnain, Durai Sundar, Sonam Grover   +7 more
doaj   +2 more sources

Consensus Molecules Associated with Parkinson’s Disease [PDF]

Neurology International
Parkinson’s disease (PD) has been associated with some types of food and drugs. Here, we query PubMed for the association of PD with foods and drugs, using a list of 217,776 compounds derived from the Human Metabolome Database (HMDB).
Sara Eyal, Shira Alfasi, Karin Ben Zaken, Ibrahim O. Sawaid, Lior Segev, Samuel Mesfin, Pnina Frankel, Rahaf Ezzy, Trishna Saha-Detroja, Shilpa Madhavan, Naamah Bloch, Baruh Polis, Abraham O. Samson   +12 more
doaj   +2 more sources

Prescribing patterns and determinants for elderly patients with Parkinson's disease in Japan: a retrospective observational study using insurance claims databases [PDF]

Frontiers in Neurology, 2023
BackgroundThis study aimed to determine real-world prescribing patterns and determinants for Japanese patients with Parkinson's disease (PD), with a focus on patients ≥75 years.MethodsThis was a retrospective, observational, longitudinal study of ...
Morinobu Seki, Yayoi Kawata, Ayako Hayashi, Masaki Arai, Shinji Fujimoto   +4 more
doaj   +3 more sources

Multitargeted docking approach reveals droxidopa against DNA replication and repair-related protein of cervical cancer [PDF]

Scientific Reports
Cervical cancer begins in the cells lining the cervix and is caused by persistent infection with certain types of human papillomavirus (HPV). Initially, it has no symptoms, and later it causes pelvic pain, abnormal vaginal bleeding, and pain during ...
Ahad Amer Alsaiari, Fawaz M. Almufarriji, Ali Hazazi, Daniyah A. Almarghalani, Maha Mahfouz Bakhuraysah, Amani A. Alrehaili, Shatha M. Algethami, Khulood A. Almehmadi, Fayez Saeed Bahwerth, Mohammed Ageeli Hakami   +9 more
doaj   +2 more sources

Prescription trends in Japanese advanced Parkinson's disease patients with non-motor symptoms: J-FIRST. [PDF]

PLoS ONE
BackgroundNon-motor symptoms (NMS) are important factors when selecting treatments for patients with advanced Parkinson's disease (PD). We sought to elucidate the prescribing practices for advanced PD patients with NMS in Japanese clinical practice ...
Masahiro Nomoto, Yoshio Tsuboi, Kenichi Kashihara, Shih-Wei Chiu, Tetsuya Maeda, Hidemoto Saiki, Hirohisa Watanabe, Yasushi Shimo, Nobutaka Hattori, Takuhiro Yamaguchi, J-FIRST Investigators   +10 more
doaj   +2 more sources

Characterization of the changes in supine blood pressure with long‐term use of droxidopa in patients with neurogenic orthostatic hypotension

Health Science Reports, 2021
Background and Aims Patients with neurogenic orthostatic hypotension (nOH) due to autonomic dysfunction may also experience supine hypertension (defined as supine systolic blood pressure [SBP] ≥140 mmHg).
L. Arthur Hewitt, Annika Lindsten, Stephen Gorny, Meghana Karnik‐Henry, Steven Kymes, Antonella Favit   +5 more
doaj   +1 more source

Financial Conflicts of Interest During Meetings of the Cardiovascular and Renal Drugs Advisory Committee [PDF]

, 2022
Context: The Cardiovascular and Renal Drugs Advisory Committee (CRDAC) of the Food and Drug Administration (FDA) reviews safety and efficacy data for cardiovascular and renal drugs, ultimately making recommendations to the Commissioner of Food and Drugs ...
Ahlander, Joseph, Arthur, Wade, Bertolino, Blake, Cooper, Craig, Gray, Harrison, Kinder, Nicholas, Simpson, Alainna, Vassar, Matt   +7 more
core   +2 more sources