Results 1 to 10 of about 1,124 (174)

Hypertensive emergency with vasogenic cerebral edema following droxidopa initiation in pure autonomic failure [PDF]

Frontiers in Neurology
Pure autonomic failure (PAF) is characterized by neurogenic orthostatic hypotension and marked blood pressure (BP) lability. Droxidopa is widely used for symptomatic management and is generally well tolerated.
Min-Ku Kim, Sung-Sik Kim, Jong-Gyu Baek
doaj   +3 more sources

Multitargeted docking approach reveals droxidopa against DNA replication and repair-related protein of cervical cancer [PDF]

Scientific Reports
Cervical cancer begins in the cells lining the cervix and is caused by persistent infection with certain types of human papillomavirus (HPV). Initially, it has no symptoms, and later it causes pelvic pain, abnormal vaginal bleeding, and pain during ...
Ahad Amer Alsaiari, Fawaz M. Almufarriji, Ali Hazazi, Daniyah A. Almarghalani, Maha Mahfouz Bakhuraysah, Amani A. Alrehaili, Shatha M. Algethami, Khulood A. Almehmadi, Fayez Saeed Bahwerth, Mohammed Ageeli Hakami   +9 more
doaj   +3 more sources

Droxidopa in Critical Care: A Systematic Review of an Emerging Off-Label Practice [PDF]

Critical Care Research and Practice
Background Prolonged use of intravenous (IV) vasopressors in critically ill patients is associated with significant complications. Droxidopa, a norepinephrine precursor approved for neurogenic orthostatic hypotension, has gained interest as an off‐label agent for facilitating vasopressor weaning in ICU settings. This systematic review aimed to evaluate
Carlos Valladares, Franklyn Vega Batista, Marc Faltas, Mareya Menteyas, Katherine Chiapaikeo-Poco   +4 more
doaj   +3 more sources

Belly dancer syndrome improved by withdrawal of droxidopa and amantadine

Clinical Case Reports, 2023
Key Clinical Message A man hospitalized for cerebral infarction developed drug‐induced belly dancer syndrome, which improved after withdrawal of droxidopa and amantadine.
Mihiro Kaga, Hiroyoshi Ueda, Chika Sunagawa, Masashi Oe, Atsushi Shima, Nobuyasu Matsukawa, Takeshi Ueda   +6 more
doaj   +2 more sources

Impact of COVID‑19 infection on subsequent prescriptions of autonomic dysfunction pharmacotherapy: a nationwide propensity‑score‑matched Cohort study in Japan [PDF]

Annals of Medicine
Background Autonomic dysfunction, including orthostatic hypotension and postural tachycardia syndrome, has emerged as a COVID-19 complication.
Daisuke Miyamori, Masanori Ito
doaj   +2 more sources

Droxidopa for Management of Chronic Hypotension in Hemodialysis [PDF]

Kidney International Reports
Anuradha Jayanti, Mohamed Elewa
doaj   +4 more sources

L-DOPA and Droxidopa: From Force Field Development to Molecular Docking into Human β₂-Adrenergic Receptor

Life, 2022
The increasing interest in the molecular mechanism of the binding of different agonists and antagonists to β2-adrenergic receptor (β2AR) inactive and active states has led us to investigate protein–ligand interactions using molecular docking calculations.
Andrea Catte, Akash Deep Biswas, Giordano Mancini, Vincenzo Barone   +3 more
doaj   +2 more sources

Consensus Molecules Associated with Parkinson’s Disease [PDF]

Neurology International
Parkinson’s disease (PD) has been associated with some types of food and drugs. Here, we query PubMed for the association of PD with foods and drugs, using a list of 217,776 compounds derived from the Human Metabolome Database (HMDB).
Sara Eyal, Shira Alfasi, Karin Ben Zaken, Ibrahim O. Sawaid, Lior Segev, Samuel Mesfin, Pnina Frankel, Rahaf Ezzy, Trishna Saha-Detroja, Shilpa Madhavan, Naamah Bloch, Baruh Polis, Abraham O. Samson   +12 more
doaj   +2 more sources

Characterization of the changes in supine blood pressure with long‐term use of droxidopa in patients with neurogenic orthostatic hypotension

Health Science Reports, 2021
Background and Aims Patients with neurogenic orthostatic hypotension (nOH) due to autonomic dysfunction may also experience supine hypertension (defined as supine systolic blood pressure [SBP] ≥140 mmHg).
L. Arthur Hewitt, Annika Lindsten, Stephen Gorny, Meghana Karnik‐Henry, Steven Kymes, Antonella Favit   +5 more
doaj   +1 more source

Droxidopa as an effective treatment for refractory neurogenic orthostatic hypotension and reflex bradycardia in amyloid light-chain amyloidosis: a case report

Journal of Medical Case Reports, 2020
Background Droxidopa is an oral treatment for the stepwise treatment of neurogenic orthostatic hypotension from autonomic dysfunction. It has been shown to be useful predominantly with neurogenic orthostatic hypotension secondary to Parkinson’s disease ...
Annie H. Ho, Christopher W. Kinter, John Wight, Anudeep R. Neelam, David Krakow   +4 more
doaj   +1 more source