Results 21 to 30 of about 1,124 (174)
Droxidopa for orthostatic hypotension: a systematic review and meta-analysis [PDF]
Objective:The systematic review and meta-analysis aims to determine the efficacy and safety of droxidopa in the treatment of orthostatic hypotension, following its recent approvals in the United States.Methods:MEDLINE, EMBASE, PubMed, Cochrane Controlled
Frith J, Tan MP, Newton JL, Strassheim V
core +4 more sources
Journal of Pharmaceutical Health Care and Sciences, 2021 Background Patients with chronic heart failure (CHF) are often treated using many diuretics for symptom relief; however, diuretic use may have to continue despite hypotension development in these patients.
Yuki Asai +6 more
doaj +1 more source
Freezing of Gait Levodopa Response Pattern in Parkinson's Disease Provides Clues to Pathophysiology. [PDF]
Eur J NeurosciABSTRACT Freezing of gait (FOG) is a common and enigmatic feature of Parkinson's disease (PD) because of its episodic and unpredictable nature. It is now clear that FOG is not a monolithic phenomenon but instead exhibits substantial heterogeneity across patients, suggesting the existence of subtypes.
Factor SA +5 more
europepmc +2 more sources
Orthostatic hypotension: An overlooked but clinically decisive entity
Journal of the Indian Academy of Geriatrics, 2022 Orthostatic hypotension (OH) is defined as a drop of >20 mm Hg of systolic or >10 mm Hg of diastolic blood pressure (BP) within 3 min of standing from lying position. It is a common geriatric syndrome caused by impaired orthostatic response of BP.
Gunja Jain +3 more
doaj +1 more source
Journal of Clinical and Translational Science, 2018 OBJECTIVES/SPECIFIC AIMS: To describe adverse behavioral symptoms attributed to droxidopa therapy for neurogenic orthostatic hypotension (nOH). METHODS/STUDY POPULATION: BACKGROUND: Droxidopa, a norepinephrine (NE) precursor, improves symptoms of nOH by ...
Katherine McDonell +4 more
doaj +1 more source
Chemistry, 2023 Tyrosine-containing pharmaceuticals’ (TPh) potential to inhibit SARS CoV-2 3-chymotrypsin-like proteases (3CLpro) and nonstructural protein 16 (NSP16) has been explored using docking studies, molecular dynamics simulations, and density functional theory.
Mohamed R. Elamin +2 more
doaj +1 more source
Droxidopa in neurogenic orthostatic hypotension [PDF]
Expert Review of Cardiovascular Therapy, 2015 Neurogenic orthostatic hypotension (nOH) is a fall in blood pressure (BP) on standing due to reduced norepinephrine release from sympathetic nerve terminals. nOH is a feature of several neurological disorders that affect the autonomic nervous system, most notably Parkinson disease (PD), multiple system atrophy (MSA), pure autonomic failure (PAF), and ...
Horacio, Kaufmann +2 more
openaire +2 more sources
Journal of Parkinson’s Disease, 2014 Background: Neurogenic orthostatic hypotension (nOH) is common in Parkinson's disease (PD), and represents a failure to generate norepinephrine responses appropriate for postural change.
Robert A. Hauser +2 more
doaj +1 more source
Use of droxidopa for blood pressure augmentation after acute spinal cord injury: case reports [PDF]
Acute and Critical CareHypotension secondary to autonomic dysfunction is a common complication of acute spinal cord injury (SCI) that may worsen neurologic outcomes. Midodrine, an enteral α-1 agonist, is often used to facilitate weaning intravenous (IV) vasopressors, but its ...
Christopher S. Hong +11 more
doaj +1 more source
Long-term safety of droxidopa in patients with symptomatic neurogenic orthostatic hypotension [PDF]
, 2016 The long-term safety of droxidopa for the treatment of symptomatic neurogenic orthostatic hypotension in patients with Parkinson disease, pure autonomic failure, multiple system atrophy, or nondiabetic autonomic neuropathy was evaluated in a phase 3 ...
Isaacson, Stuart +5 more
core +1 more source