Results 21 to 30 of about 1,420 (176)
Journal of Clinical and Translational Science, 2018 OBJECTIVES/SPECIFIC AIMS: To describe adverse behavioral symptoms attributed to droxidopa therapy for neurogenic orthostatic hypotension (nOH). METHODS/STUDY POPULATION: BACKGROUND: Droxidopa, a norepinephrine (NE) precursor, improves symptoms of nOH by ...
Katherine McDonell +4 more
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Potential drug therapies for the treatment of fibromyalgia [PDF]
, 2016 INTRODUCTION: Fibromyalgia (FM) is a common, complex chronic widespread pain condition is characterized by fatigue, sleep disturbance and cognitive dysfunction.
Lawson, Kim
core +1 more source
Droxidopa in neurogenic orthostatic hypotension [PDF]
Expert Review of Cardiovascular Therapy, 2015 Neurogenic orthostatic hypotension (nOH) is a fall in blood pressure (BP) on standing due to reduced norepinephrine release from sympathetic nerve terminals. nOH is a feature of several neurological disorders that affect the autonomic nervous system, most notably Parkinson disease (PD), multiple system atrophy (MSA), pure autonomic failure (PAF), and ...
Horacio, Kaufmann +2 more
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Contamination of the Norepinephrine Prodrug Droxidopa by Dihydroxyphenylacetaldehyde [PDF]
Clinical Chemistry, 2010 AbstractBackground: l-Threo-3,4-dihydroxyphenylserine (L-DOPS, droxidopa) is a norepinephrine (NE) prodrug under development to treat orthostatic hypotension. 3,4-Dihydroxyphenylacetaldehyde (DOPAL), an endogenous catecholaldehyde produced by enzymatic oxidative deamination of dopamine, is toxic to catecholaminergic neurons. Based on the observation of
Courtney, Holmes +3 more
openaire +3 more sources
Journal of Parkinson’s Disease, 2014 Background: Neurogenic orthostatic hypotension (nOH) is common in Parkinson's disease (PD), and represents a failure to generate norepinephrine responses appropriate for postural change.
Robert A. Hauser +2 more
doaj +1 more source
Use of droxidopa for blood pressure augmentation after acute spinal cord injury: case reports [PDF]
Acute and Critical CareHypotension secondary to autonomic dysfunction is a common complication of acute spinal cord injury (SCI) that may worsen neurologic outcomes. Midodrine, an enteral α-1 agonist, is often used to facilitate weaning intravenous (IV) vasopressors, but its ...
Christopher S. Hong +11 more
doaj +1 more source
Autonomic dysregulation in multiple sclerosis [PDF]
, 2015 Multiple sclerosis (MS) is a chronic, progressive central neurological disease characterized by inflammation and demyelination. In patients with MS, dysregulation of the autonomic nervous system may present with various clinical symptoms including ...
Adrienn Sárközi +27 more
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DNetDB: The human disease network database based on dysfunctional regulation mechanism [PDF]
, 2016 Additional analysis and concepts explanation. This file contains 1) comparison of DNetDB and the results of differential expression analysis (DEA-) based method ; 2) comparison of DNetDB and traditional disease classification; 3) negative disease ...
Fu-Yan Wang +9 more
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Clinical management of neurogenic orthostatic hypotension
Annals of Movement Disorders, 2019 Neurogenic orthostatic hypotension is a common disorder often seen in elderly patients affected with neurodegenerative disorders and peripheral neuropathies.
Malligurki Raghurama Rukmani +3 more
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Clinical Parkinsonism & Related Disorders, 2022 Introduction: Orthostatic hypotension (OH) and abnormal blood pressure (BP) fluctuations occur mainly due to noradrenergic dysfunction and are clinically important in patients with Parkinson’s disease (PD). They lead to impairments of cognition function,
Hisayoshi Oka +3 more
doaj +1 more source