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Annals of the New York Academy of Sciences, 2022
AbstractThe evolution of the nervous system progressed through cellular diversification and specialization of functions. Conceptually, the nervous system is composed of electrically excitable neuronal networks connected by chemical synapses and nonexcitable glial cells that provide for homeostasis and defense.
Alexei Verkhratsky +3 more
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AbstractThe evolution of the nervous system progressed through cellular diversification and specialization of functions. Conceptually, the nervous system is composed of electrically excitable neuronal networks connected by chemical synapses and nonexcitable glial cells that provide for homeostasis and defense.
Alexei Verkhratsky +3 more
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Neuroglia in Psychiatric Disorders
2021In the twentieth century, neuropsychiatric disorders have been perceived solely from a neurone-centric point of view, which considers neurones as the key cellular elements of pathological processes. This dogma has been challenged thanks to the better comprehension of the brain functioning, which, even if far from being complete, has revealed the ...
Scuderi, Caterina +3 more
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Calcium signaling in neuroglia
2021Glial cells exploit calcium (Ca2+) signals to perceive the information about the activity of the nervous tissue and the tissue environment to translate this information into an array of homeostatic, signaling and defensive reactions. Astrocytes, the best studied glial cells, use several Ca2+ signaling generation pathways that include Ca2+ entry through
Dmitry Lim +5 more
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Neuroglia in neurodegeneration
Brain Research Reviews, 2010Neuroglial cells are fundamental for control of brain homeostasis and they represent the intrinsic brain defence system. All forms in neuropathology therefore inevitably involve glia. The neurodegenerative diseases disrupt connectivity within brain circuits affecting neuronal-neuronal, neuronal-glial and glial-glial contacts.
Michael T. Heneka +3 more
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Nanostructured Modulators of Neuroglia
Current Pharmaceutical Design, 2019Biological and synthetic nanostructures can influence both glia and neurons in the central nervous system. Neurons represent only a small proportion (about 10%) of cells in the brain, whereas glial cells are the most abundant cell type. Non-targeted nanomedicines are mainly internalized by glia, in particular microglia, and to a lesser extent by ...
Dusica Maysinger, Jeff Ji
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Suicide is the worst outcome for many neuropsychiatric disorders having a high social and economic burden. There is a great need to determine the neurobiologic background of the etiopathogenesis and resilience toward suicide and to find novel pharmacologic strategies to treat suicidal behaviors.
Zhang, Lin, Swaab, Dick F
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Zhang, Lin, Swaab, Dick F
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Aging is associated with morphologic and functional decline of the brain active milieu and, in particular, of the neuroglia, which compromises homeostatic support and neuroprotection. Astrocytes in aging undergo complex and region specific changes, manifested by morphologic atrophy and widespread functional asthenia.
Alexey, Semyanov, Alexei, Verkhratsky
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Alexey, Semyanov, Alexei, Verkhratsky
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