Results 141 to 150 of about 212,554 (299)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Galectin-3 shapes microglial phenotype through endogenous and exogenous mechanisms

Frontiers in Cellular Neuroscience
Galectin-3 (Gal3) is a multifunctional lectin expressed and released by microglia, where it influences diverse processes in both homeostasis and disease.
Lluís Camprubí-Ferrer, Yiyi Yang, Rosalía Fernández-Calle, Antonio Boza-Serrano, Antonio Boza-Serrano, Antonio Boza-Serrano, Juan García-Revilla, Juan García-Revilla, Juan García-Revilla, Javier Frontiñán-Rubio, Tomas Deierborg   +10 more
doaj   +1 more source

Polyphenols Derived from Lychee Seed Suppress Aβ (1-42)-Induced Neuroinflammation [PDF]

, 2018
Yong Tang, Rui Xiong, Anguo Wu, Chong‐Lin Yu, Ya Zhao, Wenqiao Qiu, Xiuling Wang, Jin‐Feng Teng, Jian Liu, Hạixia Chen, Jianming Wu, Dalian Qin   +11 more
openalex   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

The ABILHAND‐23 Patient Reported Outcome Measure in Secondary Progressive Multiple Sclerosis: A Cross‐Sectional Analysis With the Nine Hole Peg Test

Brain and Behavior
Background People with progressive multiple sclerosis (pwPMS), who typically have established lower limb dysfunction, experience greater disability from upper limb dysfunction (ULD).
Sean Apap Mangion, Charles Wade, Tom Williams, Alessia Bianchi, Floriana De Angelis, Sarah Wright, Nevin John, Anisha Doshi, Alberto Calvi, Obioma Oraluzume, Maya Leibowitz, Guglielmo Vecchio, James Blackstone, Marie Braisher, Graziella Favarato, Jennifer Nicholas, Rachel Farrell, Jeremy Chataway, The UCL MS‐STAT2 Investigators   +18 more
doaj   +1 more source

Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson’s disease [PDF]

, 2015
Changyoun Kim, Emmanuel A. Ojo-Amaize, Brian Spencer, Edward Rockenstein, Michael Mante, Paula Desplats, Wolf Wrasidlo, Anthony Adame, Emeka J. Nchekwube, Olusola A. Oyemade, Joseph I. Okogun, Michael Chan, Howard B. Cottam, Eliezer Masliah   +13 more
openalex   +1 more source

Ethylmethylhydroxypyridine Succinate Limits Stress-Induced Neuroinflammation in the Cerebral Cortex of Old Rats

, 2023
О. L. Terekhina, Yu. I. Kirova
openalex   +2 more sources

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source