Data-driven modeling and prediction of microglial cell dynamics in the ischemic penumbra [PDF]
arXivNeuroinflammation immediately follows the onset of ischemic stroke. During this process, microglial cells are activated in and recruited to the tissue surrounding the irreversibly injured infarct core, referred to as the penumbra. Microglial cells can be activated into two distinct phenotypes; however, the dynamics between the detrimental M1 phenotype ...
arxiv
Amyloid-Beta Peptide Is Toxic to Neurons In Vivo via Indirect Mechanisms
Neurobiology of Disease, 2002 We have studied the neurotoxicity of amyloid-beta (Aβ) after a single unilateral intravitreal injection. Within the retina apoptotic cells were seen throughout the photoreceptor layer and the inner nuclear layer but not in the ganglion cell layer at 48 h
Desmond T. Walsh +9 more
doaj
The cellular response in neuroinflammation: The role of leukocytes, microglia and astrocytes in neuronal death and survival [PDF]
, 2006 Monica J. Carson +2 more
openalex +1 more source
Advanced Science, EarlyView.Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian +5 more
wiley +1 more source
Self‐Assembly of Linear, Natural Antimicrobial Peptides: An Evolutionary Perspective
ChemPlusChem, Volume 87, Issue 12, December 2022., 2022 Antimicrobial peptides are an ancient defence against a wide range of microbes. Some can self‐assemble into oligomers and amyloid. Similarities with neurodegenerative diseases support a hypothesis that some diseases are due to aberrant activity of a protective neuropeptide.
Verity Baltutis +2 more
wiley +1 more source
The many roads to dementia: a systems view of Alzheimer's disease [PDF]
arXivAlzheimer's disease is not the outcome of a single cause but the convergence of many. This review reframes dementia as a systemic failure, where amyloid plaques and tau tangles are not root causes but late-stage byproducts of the underlying metabolic collapse.
arxiv
Chemokines Regulate the Migration of Neural Progenitors to Sites of Neuroinflammation [PDF]
, 2006 Abdelhak Belmadani +3 more
openalex +1 more source
Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis [PDF]
, 2006 Farshid Noorbakhsh +9 more
openalex +1 more source
HDL‐Apolipoprotein in Alzheimer's Disease Revisited: From Periphery to CNS
AGING MEDICINE, EarlyView.HDL‐apolipoproteins in the periphery and CNS contribute differently to Alzheimer's disease, influencing Aβ, p‐tau, brain structures, and cognition. Apolipoprotein AI and E, key HDL components in blood and CSF, may either protect against or accelerate AD, depending on their location. Created with BioGDP.com. ABSTRACT High‐density lipoprotein (HDL), as a
Yihong Huang +8 more
wiley +1 more source